Review
Biochemistry & Molecular Biology
Sara Trova, Serena Bovetti, Sara Bonzano, Silvia De Marchis, Paolo Peretto
Summary: Steroid hormones play important roles in vertebrates, especially in mammalian sexual development and brain neural circuits. Studies in recent decades have shown that sex steroids influence the organization of the brain structure during puberty, a critical period characterized by high sensitivity to external stimuli and significant remodeling of the organism's structure and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yongquan Yu, Di Zhang, Jiayi Xu, Daiwei Zhang, Liu Yang, Rong Xia, Shou-Lin Wang
Summary: This study investigates the association between acrylamide (AA) and sex hormones, particularly in adolescents. The findings suggest a negative correlation between AA and sex hormones, and indicate that AA can disrupt the hypothalamic-pituitary-gonadal (HPG) axis and injure gonadotropin-releasing hormone (GnRH) neurons, leading to reduced testosterone and estradiol levels in puberty.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Deborah Gomes da Silva, Kawane Fabricio Moura, Amanda Cristina de Souza, Kenny Gutemerg Nunes da Silva, Camila Borecki Vidigal, Juliana da Silva Jezuino, Rafaella Cardoso Gravena, Gislaine Garcia Pelosi, Daniela Cristina Ceccato Gerardin, Maria do Carmo Franco, Graziela Scalianti Ceravolo
Summary: This study aimed to evaluate the short and long-term adverse effects of the antiepileptic drug topiramate (TPM) on blood pressure, vascular endothelial function, and estrogen receptor modulation in female rats during the peripubertal period. The results showed that TPM treatment did not alter aortic endothelial function or estrogen modulation via classic ER in female rats, indicating that TPM treatment during this period is safe for the vascular system.
Article
Behavioral Sciences
Thanh Phung, Firyal Ramzan, Ashley Monks
Summary: Although copulatory behavior in mice is believed to have a strong innate basis, sexual experience also plays a role in shaping its expression. Rewarding genital tactile stimulation is considered a primary mechanism for modifying behavior, and research has shown that both continuous and distributed stimulation can be rewarding.
HORMONES AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Lee T. Gettler, Stacy Rosenbaum, Patty X. Kuo, Mallika S. Sarma, Sonny Agustin Bechayda, Thomas W. McDade, Christopher W. Kuzawa
Summary: Testosterone plays an important role in reproductive trade-offs and can be influenced by developmental experiences and family environments. A study in the Philippines found that sons who had fathers involved in childcare during adolescence had lower testosterone levels as parents. Adolescent father-son relationships also played a contributing role, with sons having lower waking testosterone if they credited their fathers with their upbringing. These findings suggest a potential pathway for the intergenerational transmission of reproductive strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Wietse In het Panhuis, Milena Schoenke, Ricky Siebeler, Dorien Banen, Amanda C. M. Pronk, Trea C. M. Streefland, Salwa Afkir, Hetty C. M. Sips, Jan Kroon, Patrick C. N. Rensen, Sander Kooijman
Summary: Circadian disruption affects glucose and lipid metabolism with sex-specific effects. This study demonstrates that circadian disruption has sex-dependent effects on glucose metabolism, aggravated by male sex hormones and partially rescued by female sex hormones.
Article
Anesthesiology
Kali Hankerd, Ho Koo, Kathleen E. McDonough, Jigong Wang, Ramesh Pariyar, Shao-Jun Tang, Jin Mo Chung, Jun-Ho La
Summary: This study found that gonadal hormones are critical for the development and maintenance of peripherally maintained nociplastic pain state in females. Estradiol reconstitution before injury and post-injury stimulation can restore the development of this pain state, while G protein-coupled estrogen receptor antagonism can alleviate the pain. AITC-responsive afferents contribute to the maintenance of nociplastic mechanical hypersensitivity in females.
Article
Neurosciences
Hannah L. Mayberry, Heather A. DeSalvo, Charlotte C. Bavley, Sara H. Downey, Cindy Lam, Charita Kunta, Ricardo P. Fortuna, Priya H. Doshi, Elizabeth B. Smedley, Mathieu E. Wimmer
Summary: This study aimed to explore the behavioral and affective signatures associated with craving, as well as the influence of the female estrous cycle on craving. The results showed that lever pressing and overall locomotion increased uniformly over extended abstinence from heroin and sucrose, but there emerged a sex- and reinforcer-specific behavioral and affective signature of craving. Furthermore, although the female estrous cycle did not affect taking or seeking, it appeared to influence more granular behaviors.
Article
Clinical Neurology
Jinfeng Wang, Ying Qing, Jinfeng Liang, Gaoping Cui, Qian Wang, Juan Zhang, Xuhan Yang, Minghui Li, Dandan Wang, Zhiyong Fan, Kangkang Chu, Jiuping Zhang, Xiaoyan Ke, Chunling Wan
Summary: This study provides the first evidence of the utility of NSFR as an objective auxiliary diagnostic biomarker for adolescent depression. It helps promote precise diagnosis, treatment, and prognostic evaluation of adolescent depression, and provides new clues to understand the pathophysiology of the disease.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Article
Environmental Sciences
Lin-Na Xu, Hui-Ting Li, Shuang Liu, Jie Jiang, Ya-Qin Liu, Hai-Ying Mary Cheng, Yang Yu, Ji-Min Cao, Peng Zhang
Summary: This study investigated the effects of chronic circadian disturbance (CCD) during fetal stage on the pubertal development of female mice. The results showed that CCD exposure led to delayed puberty in female mice, characterized by lower body weight, decreased hormone levels, and altered gene expression in the ovary and hypothalamus. Additionally, disrupted expression of genes associated with fatty acid metabolism and circadian clock was observed in the ovaries of these mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Behavioral Sciences
Courtney M. Klappenbach, Qing Wang, Allison L. Jensen, Nicholas C. Glodosky, Kristen Delevich
Summary: Gonadal sex steroids play a crucial role in regulating energy balance in adult rodents and their effects on weight gain differ in sexually mature males and females after gonadectomy (GDX). However, the role of gonadal hormones during puberty remains uncertain. In this study, we performed GDX or sham surgery on male and female C57Bl/6 mice at prepubertal (P25) or postpubertal (P60) stages and measured weight, body composition, and feeding behaviors. Our results showed that postpubertal GDX led to weight gain in females and weight loss in males, while prepubertal GDX affected weight gain and body composition changes only in males. However, GDX decreased food intake and motivation for food in all groups regardless of sex or timing of surgery relative to puberty.
HORMONES AND BEHAVIOR
(2023)
Article
Geriatrics & Gerontology
Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole, Jason J. Paris
Summary: Hypogonadism is a common comorbidity associated with HIV-1, more prevalent among individuals over 45. Tat protein expression may accelerate age-related comorbidities by impairing endocrine function. Studies found that Tat protein and endocrine aging status have separate and interacting effects on anxiety-like behavior and cognition, with peri- and post-estropausal mice showing more severe symptoms.
Article
Immunology
Minxiu Ye, Haitao Xiang, Huijun Liu, Zhichao Hu, Yue Wang, Yue Gu, Xu Lu, Chao Huang
Summary: Pre-stimulation of the innate immune system may prevent depression- and anxiety-like behaviors in adult mice induced by adolescent alcohol exposure by preventing neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Sijie Wang, Jingwen Zhang, Shaozhi Zhang, Feifei Shi, Daofu Feng, Xizeng Feng
Summary: Exposure to MCA can result in abnormal behaviors and emotions in mice, including enhanced locomotor and nocturnal activity, as well as anxiety-like and depression-like behaviors. Serum concentrations of thyroid-related hormones and mRNA levels were also affected by MCA exposure, indicating potential hormonal disruptions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Anatomy & Morphology
Yvonne M. Ulrich-Lai, Anne M. Christiansen, Xia Wang, Seongho Song, James P. Herman
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Endocrinology & Metabolism
Deanna M. Arble, Jenna Holland, Nickki Ottaway, Joyce Sorrell, Joshua W. Pressler, Rachel Morano, Stephen C. Woods, Randy J. Seeley, James P. Herman, Darleen A. Sandoval, Diego Perez-Tilve
Article
Endocrinology & Metabolism
Matia B. Solomon, Matthew Loftspring, Annette D. de Kloet, Sriparna Ghosal, Ryan Jankord, Jonathan N. Flak, Aynara C. Wulsin, Eric G. Krause, Rong Zhang, Taylor Rice, Jessica McKlveen, Brent Myers, Jeffrey G. Tasker, James P. Herman
Article
Endocrinology & Metabolism
Jebun Nahar, Juhee Haam, Chun Chen, Zhiying Jiang, Nicholas R. Glatzer, Louis J. Muglia, Gary P. Dohanich, James P. Herman, Jeffrey G. Tasker
Article
Neurosciences
Brent Myers, Eduardo Carvalho-Netto, Dayna Wick-Carlson, Christine Wu, Sam Naser, Matia B. Solomon, Yvonne M. Ulrich-Lai, James P. Herman
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Immunology
Brittany L. Smith, Sarah N. Schmeltzer, Benjamin A. Packard, Renu Sah, James P. Herman
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Article
Endocrinology & Metabolism
Alier J. Franco, Chun Chen, Tyler Scullen, Andrea Zsombok, Ahmed A. Salahudeen, Shi Di, James P. Herman, Jeffrey G. Tasker
Article
Endocrinology & Metabolism
Aynara C. Wulsin, Dayna Wick-Carlson, Benjamin A. Packard, Rachel Morano, James P. Herman
PSYCHONEUROENDOCRINOLOGY
(2016)
Editorial Material
Behavioral Sciences
Daniela Jezova, James P. Herman
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2016)
Article
Behavioral Sciences
Susan E. Martelle, Evelin M. Cotella, Nawshaba Nawreen, Carrie Chen, Benjamin A. Packard, Maureen Fitzgerald, James P. Herman
Summary: PACAP is highly expressed in putative pyramidal neurons in the infralimbic cortex of rats, while PAC1 is enriched in interneurons. Infusion of PACAP into the IL alters stress responses, increases anxiety-like behavior, and enhances fear memory retention in rodents.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Review
Neurosciences
Jason J. Radley, James P. Herman
Summary: The experience of prolonged stress leads to changes in how individuals interact with their environment and process interoceptive cues, aiming to optimize survival in a hostile world. The chronic stress response involves various alterations that limit further harm, including the development of behavioral strategies and metabolic adjustments. While chronic stress is often linked to pathology, we argue that it is actually an adaptive defense mechanism. Pathology occurs only when the organism's adaptive capacity is depleted. This perspective helps interpret chronic stress studies in animal models in relation to adaptation rather than pathology.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
James P. Herman, Nawshaba Nawreen, Marissa A. Smail, Evelin M. Cotella
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Review
Neurosciences
Millie Rincon-Cortes, James P. Herman, Sonia Lupien, Jamie Maguire, Rebecca M. Shansky
NEUROBIOLOGY OF STRESS
(2019)
Article
Physiology
James P. Herman, Jessica M. McKlveen, Sriparna Ghosal, Brittany Kopp, Aynara Wulsin, Ryan Makinson, Jessie Scheimann, Brent Myers
COMPREHENSIVE PHYSIOLOGY
(2016)
Review
Cell Biology
James P. Herman
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2018)