Review
Neurosciences
Rodrigo C. Meza, Carlos Ancaten-Gonzalez, Chiayu Q. Chiu, Andres E. Chavez
Summary: This article discusses the roles of TRPV1 in both central and peripheral systems, exploring its regulation of synaptic function and potential therapeutic applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tricia Rowlison, Pierre Comizzoli
Summary: Key protein LGALS3BP is transferred via extracellular vesicles between the epididymis and maturing sperm cells, and this transfer affects sperm fertilizing ability and developmental potential. Inhibition of LGALS3BP leads to decreased fertilization success and slower first cell cycles, demonstrating the importance of LGALS3BP in sperm function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Reproductive Biology
Coline Mahe, Aleksandra Maria Zlotkowska, Karine Reynaud, Guillaume Tsikis, Pascal Mermillod, Xavier Druart, Jennifer Schoen, Marie Saint-Dizier
Summary: After mating or insemination, the region-specific and hormonally regulated morphology and secretions of the utero-tubal junction and oviduct lead to the selection of a limited sub-population of top quality spermatozoa at the site of fertilization.
BIOLOGY OF REPRODUCTION
(2021)
Article
Medicine, Research & Experimental
Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotomi
Summary: Olfactory disorders, closely related to cognitive deterioration, can be caused by infections, aging, and environmental chemicals. This study focused on the involvement of TRPV1 and TRPV4 channels in olfactory receptor neuron (ORN) regeneration, demonstrating that TRPV1 stimulates progenitor cell proliferation while TRPV4 regulates proliferation and maturation, suggesting their essential roles in ORN regeneration.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian
Summary: In this study, three series of new piperazine urea TRPV1 antagonists were designed, synthesized, and evaluated, among which compound 5ac showed excellent TRPV1 antagonistic activity, good bioavailability, and no hyperthermia side effects. The molecular docking study revealed that compound 5ac interacted well with the amino acid residues on rTRPV1 through hydrophobic interaction, making it an efficient TRPV1 antagonist and a potential candidate for analgesic drug development.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Sung-Min Hwang, Youn-Yi Jo, Cinder Faith Cohen, Yong-Ho Kim, Temugin Berta, Chul-Kyu Park
Summary: This review focuses on the mechanisms by which venom-derived peptides interact with the outer pore region of TRPV1 to control receptor functions and how these mechanisms can drive the development of new types of analgesics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fangjie Jin, Yuting Wen, Guoqiang Lin, Shaopeng Yu, Chao Wang, Wenbo Ye, Jiange Zhang
Summary: Pain-relief is a long-term research topic with high clinical demand. TRPV1 has been identified as a potential target for the development of analgesic agents. A series of novel TRPV1 agonists, based on Cannabidiol, were designed and synthesized, with compound 10f showing promising TRPV1 agonistic activity, higher target affinity, stronger analgesic activity, and weak side effects.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Physiology
Guangxin Peng, Xiaoling Tang, Yang Gui, Jing Yang, Lifang Ye, Liuyang Wu, Ya Hui Ding, Lihong Wang
Summary: TRPV1 plays a significant role in fibrotic diseases, regulating the fibrotic processes and potentially serving as a therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Lin Shang, Siqi Zhao, Huijuan Shi, Xinzhu Xing, Jingya Zhang, Yanling He
Summary: Pruritus is a common and painful symptom in psoriasis that greatly affects quality of life. Neurogenic inflammation induced pruritus is the predominant mechanism in psoriasis, with the nerve growth factor (NGF)-mediated TRPV1 pathway playing a crucial role. However, the development of systemic TRPV1 antagonists has been hindered by elevated core temperature. Therefore, topical application of TRPV1 antagonists and interference with TRPV1 activation pathway mediators could be promising therapeutic options. This review focuses on recent advances in understanding the complex regulation of the NGF-mediated TRPV1 pathway in psoriatic pruritus and the potential therapeutic approaches derived from this knowledge.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiqi Yan, Jun Tang, Xin Zhang, Liuyang Wu, Yunyi Xu, Lihong Wang
Summary: TRPV1 channel plays a beneficial role in heart diseases, but the specific mechanism in pathological myocardial hypertrophy remains unclear, posing a research gap. The study aims to provide new treatment targets for pathological myocardial hypertrophy by summarizing the role and mechanism of TRPV1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Lee
Summary: This study found that capsaicin can promote autophagy and reduce the abnormal accumulation of tau protein by activating the TRPV1 channel, thereby improving synaptic damage and cognitive impairment. Experimental validation showed that this effect is mediated by the AMPK/mTOR signaling pathway. The results of this study reveal the role of capsaicin in restoring tau protein homeostasis through modulating cellular autophagy and support the potential of TRPV1 as a therapeutic target for tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Costanza Cimini, Marina Ramal-Sanchez, Angela Taraschi, Flavio Della Pelle, Annalisa Scroccarello, Ramses Belda-Perez, Luca Valbonetti, Paola Lanuti, Marco Marchisio, Mario D'Atri, Claudio Ortolani, Stefano Papa, Giulia Capacchietti, Nicola Bernabo, Dario Compagnone, Barbara Barboni
Summary: Nowadays, there is a growing adoption of In Vitro Fertilization (IVF) techniques. A promising strategy is the use of non-physiological materials and naturally derived compounds for advanced sperm preparation methods. The study showed that MoS2/Catechin nanoflakes and catechin (CT) did not have any negative effects on sperm capacitation, while adding a specific concentration of CT increased the fertilizing ability of sperm in an IVF assay. These findings suggest that catechins and new materials obtained using natural or bio compounds could enhance current sperm capacitation strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfeng Zhang, Yantao Xu, Yingxu Ma, Tianjian Xie, Chan Liu, Qiming Liu
Summary: This article provides a bibliometric analysis of the relationship between transient receptor potential vanilloid (TRPV) and cardiovascular system disease. The findings show significant growth in the field since 2008, with the United States and China in dominant positions. The study suggests the need for intercontinental cooperation and future research on pharmacological mechanisms and new clinical disease application areas.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hideaki Yamada, Naoaki Sakata, Tomoko Tanaka, Hideaki Tagashira, Gumpei Yoshimatsu, Ryo Kawakami, Hideichi Wada, Takahiro Iwamoto, Shohta Kodama
Summary: This study showed that activating TRPV4 can improve blood flow in the ischemic hindlimb animal model by promoting both angiogenesis and lymphangiogenesis. It suggests that upregulating both lymphatic and blood vessels through TRPV4 activation could be a promising therapeutic strategy for peripheral artery disease.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Lucia Scipioni, Francesca Ciaramellano, Veronica Carnicelli, Alessandro Leuti, Anna Rita Lizzi, Noemi De Dominicis, Sergio Oddi, Mauro Maccarrone
Summary: This article reviews the role of microglial cells in chronic inflammation in Alzheimer's disease (AD) and the involvement of endocannabinoids in regulating their activity.
Article
Biochemistry & Molecular Biology
Stefania Mardente, Michele Aventaggiato, Elena Splendiani, Emanuela Mari, Alessandra Zicari, Giuseppina Catanzaro, Agnese Po, Lucia Coppola, Marco Tafani
Summary: Thyroid cancer, particularly papillary thyroid cancer (PTC), is becoming more common worldwide. Some papillary tumors exhibit metastasis and aggressive behavior due to de-differentiation caused by epithelial-mesenchymal transition (EMT). The tumor microenvironment, hypoxia, and the secretion of HMGB1 and other factors contribute to this aggressive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniel Tortolani, Camilla Di Meo, Sara Standoli, Francesca Ciaramellano, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone
Summary: Rare cannabis-derived phytocannabinoids (pCBs) have therapeutic potential in skin disorders and their anti-inflammatory effects were investigated in this study. The experiment involved using lipopolysaccharide (LPS) to induce inflammation in human keratinocytes (HaCaT cells) and measuring the levels of pro-inflammatory interleukins. The results showed that pCBs significantly reduced the release of pro-inflammatory interleukins and modulated MAPK signaling, suggesting their potential as a treatment for inflammation-related skin pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Donatella Ambroselli, Fabrizio Masciulli, Enrico Romano, Giuseppina Catanzaro, Zein Mersini Besharat, Maria Chiara Massari, Elisabetta Ferretti, Silvia Migliaccio, Luana Izzo, Alberto Ritieni, Michela Grosso, Caterina Formichi, Francesco Dotta, Francesco Frigerio, Eleonora Barbiera, Anna Maria Giusti, Cinzia Ingallina, Luisa Mannina
Summary: The definition of metabolic syndrome (MetS) has changed over time due to the difficulty in establishing universal criteria. MetS is associated with a pro-inflammatory state related to altered glucose metabolism, leading to increased cardiovascular risk. Complications of MetS include cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Genetic factors, human microbiota, and diet play complex roles in the predisposition to MetS. This review summarizes the literature of the past decade on MetS, including its definition, pathophysiology, treatment approaches, prediction and diagnosis using advanced methodologies, and the role of specific foods in prevention and/or treatment.
Review
Pharmacology & Pharmacy
Luana Abballe, Zaira Spinello, Celeste Antonacci, Lucia Coppola, Ermanno Miele, Giuseppina Catanzaro, Evelina Miele
Summary: Primary malignant brain tumors are common in childhood and there is a need for more effective therapies. Cancer stem cells (CSCs) have been identified in pediatric brain tumors and are resistant to conventional treatments. Understanding the specific features of CSCs has provided opportunities to develop targeted therapies. Nanomedicine offers novel approaches for treating pediatric brain tumors, including the use of nanoparticles (NPs) decorated with biomolecules. This review summarizes nanoparticle-based approaches to target CSCs in the tumor bulk.
Editorial Material
Biochemistry & Molecular Biology
Giuseppina Catanzaro
Article
Biochemistry & Molecular Biology
Sara Standoli, Cinzia Rapino, Camilla Di Meo, Agnes Rudowski, Nicole Kaempfer-Kolb, Luisa Michelle Volk, Dominique Thomas, Sandra Trautmann, Yannick Schreiber, Dagmar Meyer zu Heringdorf, Mauro Maccarrone
Summary: Microglia, the immune cells of the central nervous system, have important roles in brain homeostasis and various neurological diseases. This study investigates the interaction between the endocannabinoid system and the sphingosine kinase/sphingosine-1-phosphate system in microglia. The results reveal that inhibiting the fatty acid amide hydrolase enzyme and activating the cannabinoid 2 receptor have anti-inflammatory effects and prevent the transcription of pro-inflammatory SphK1 and SphK2 in microglia cells challenged with lipopolysaccharide. The findings suggest the development of inhibitors for these enzymes as potential treatments for neuroinflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Annamaria Tisi, Giulia Carozza, Alessandro Leuti, Rita Maccarone, Mauro Maccarrone
Summary: The study investigates the alterations of RvE1 metabolism and signaling in an animal model of age-related macular degeneration (AMD), and suggests a potentially relevant role of this pathway in AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gianna Rossi, Valentina Di Nisio, Alessandro Chiominto, Sandra Cecconi, Mauro Maccarrone
Summary: This study aimed to investigate the expression levels of the main receptors and metabolic enzymes of the endocannabinoid system in the ovaries, oviducts, and uteri of mice at different reproductive stages. The results showed that TRPV1 receptor had the highest expression and significantly increased during aging, while NAPE-PLD, FAAH, and DAGL-beta enzymes were the most expressed in these organs and increased with age. Immunohistochemistry revealed the distribution of these proteins in specific cells in each organ. These findings provide new insights into the role of the endocannabinoid system in female reproduction and its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mauro Maccarrone
Summary: Lipids, traditionally known for their role as metabolic fuel and structural membrane components, have been found to act as authentic messengers between cells and regulate various biological processes in the body. This article focuses on endogenous bioactive lipids, particularly those derived from arachidonic acid (AA), and their interactions with other lipids, enzymes, and receptors. The metabolic and signal transduction pathways of classical eicosanoids, endocannabinoids, specialized pro-resolving mediators, and other bioactive lipids such as shingosine-1-phosphate and steroid hormones will be discussed.
Review
Pharmacology & Pharmacy
Mauro Maccarrone, Vincenzo Di Marzo, Jurg Gertsch, Uwe Grether, Allyn C. Howlett, Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda, Mario van der Stelt
Summary: Marijuana, a widely used recreational drug, has seen a change in risk perception due to its legalization and medical use. Research has shown the therapeutic potential of cannabinoids for various diseases, and our body's endocannabinoid system plays a crucial role in this. Understanding the components and functions of this system can lead to new treatment opportunities.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Oncology
Anna Citarella, Giuseppina Catanzaro, Zein Mersini Besharat, Sofia Trocchianesi, Federica Barbagallo, Giorgio Gosti, Marco Leonetti, Annamaria Di Fiore, Lucia Coppola, Tanja Milena Autilio, Zaira Spinello, Alessandra Vacca, Enrico De Smaele, Mary Anna Venneri, Elisabetta Ferretti, Laura Masuelli, Agnese Po
Summary: Colorectal cancer is a leading cause of cancer-related deaths, and chemoresistance is a major issue. The activation of Hedgehog-GLI and NOTCH signaling pathways plays a role in chemoresistance and the epithelial-to-mesenchymal transition (EMT) in colorectal cancer. In KRAS-mutated CRC, the inhibition of both the HH-GLI and NOTCH pathways is necessary to enhance chemosensitivity, while in BRAF-mutated CRC, the inhibition of HH-GLI alone is sufficient to promote chemosensitivity.
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Review
Biochemistry & Molecular Biology
Annamaria Tisi, Sakthimala Palaniappan, Mauro Maccarrone
Summary: This article presents the application of advanced omics techniques, such as genomics, transcriptomics, and epigenomics, in cochlear research. The article also introduces the latest technologies, including single-cell omics and spatial omics, for investigating molecular events at a single-cell resolution with spatial information.
Article
Neurosciences
Michela Bossa, Ornella Argento, Chiara Piacentini, Nicola Manocchio, Lucia Scipioni, Sergio Oddi, Mauro Maccarrone, Ugo Nocentini
Summary: This project aims to evaluate the anti-neuroinflammatory effects of oral administration of N-palmitoylethanolamine (PEA) in subjects with mild cognitive impairment (MCI) through cognitive evaluation and biochemical analyses. The specific objectives are to determine whether PEA can affect neuropsychological and behavioral scores, change inflammatory and neuronal damage markers in MCI subjects, and if these changes correlate with clinical scores.