Article
Pharmacology & Pharmacy
Zheng Zhang, Mengjie Li, Bo Cui, Xiao Chen
Summary: The combination of a high salt diet and antibiotics significantly alters the gut microbial community, increasing opportunistic pathogens and reducing probiotic species. Furthermore, this combination affects gut metabolism, specifically entero-hepatic circulation, tryptophan metabolism, and lipid metabolism, which may contribute to liver damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Minxuan Xu, Chenxu Ge, Liancai Zhu, Yuting Qin, Chengjiang Du, Deshuai Lou, Qiang Li, Linfeng Hu, Yan Sun, Xianling Dai, Mingxin Xiong, Tingting Long, Jianxia Zhan, Qin Kuang, Huanhuan Li, Qiufeng Yang, Ping Huang, Xuepeng Teng, Jing Feng, Yekuan Wu, Wei Dong, Bochu Wang, Jun Tan
Summary: The study demonstrates that iRhom2 plays a crucial role in promoting hepatic steatosis and insulin resistance. Mice with iRhom2 deficiency show less severe hepatic steatosis and insulin resistance, indicating iRhom2 as a potential therapeutic target for NAFLD-related complications.
Article
Biotechnology & Applied Microbiology
Robert Kammerer, Wolfgang Zimmermann
Summary: This study found that Psg genes are only present in the suborder Myomorpha of rodents, and these genes are located in a specific region of the genome and are highly expressed by trophoblast cells. In contrast, Psg genes were not found in other suborders. This suggests that Psg genes have evolved recently in rodents.
Article
Biology
S. Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Johannes Sam, Tina Weinzierl, Tanja Fauti, Anne Freimoser-Grundschober, Jan Eckmann, Carina Hage, Martina Geiger, Patrick Ray Ng, William Tien-Street, Dimitris Manatakis, Virginie Micallef, Regine Gerard, Michael Bscheider, Ekaterina Breous-Nystrom, Anneliese Schneider, Anna Maria Giusti, Cristina Bertinetti-Lapatki, Heather Shannon Grant, Adrian B. Roth, Geraldine A. Hamilton, Thomas Singer, Katia Karalis, Annie Moisan, Peter Bruenker, Christian Klein, Marina Bacac, Nikolce Gjorevski, Lauriane Cabon
Summary: This study demonstrated the unprecedented capability of two human Organs-on-Chips in evaluating the safety profile of T-cell bispecific antibodies targeting tumor antigens, predicting TCB safety liabilities based on target expression and antibody affinity. These novel tools broaden research options for understanding engineered therapeutic antibodies and assessing safety in tissues susceptible to adverse events.
Article
Biochemistry & Molecular Biology
Tongtong Che, Yukun Song, Wentao Su, Shanghua Xing, Haitao Wang, Mingqian Tan
Summary: In this study, hepatic parenchymal cell and mitochondrial-targeted nanocarriers were developed to deliver AST to liver tissue for improved intervention in NAFLD. The AST@TPP-WPI-Gal nanocarriers exhibited dual targeting capability and effectively targeted mitochondria in steatotic cells, leading to enhanced anti-oxidative and anti-adipogenesis effects. In an NAFLD mice model, the AST@TPP-WPI-Gal nanocarriers showed the ability to regulate blood lipid disorders, protect liver function, and significantly reduce liver lipid accumulation compared to free AST.
Review
Biochemistry & Molecular Biology
Yi-Hsing Chen, Sue Lightman, Malihe Eskandarpour, Virginia L. Calder
Summary: CAM-based therapies have shown benefits in controlling experimental autoimmune uveitis, especially through the ICAM-1/LFA-1 and VCAM-1/VLA-4 pathways. P-selectin and E-selectin are mainly involved in uveitis related to vasculitis. Localized therapies are the future direction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Feredun Azari, Gregory T. Kennedy, Ashley Chang, Elizabeth Bernstein, Bilal Nadeem, Andre Pelegrin, Francoise Cailler, Neil T. Sullivan, John Kucharczuk, Sunil Singhal
Summary: This study suggests that CEACAM5 may serve as a potential target for targeted intraoperative molecular imaging resections in lung cancer. The study paves the way for evaluating CEACAM5 targets in future clinical trials.
ANNALS OF THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: In this study using a rat model, it was found that infants with infantile spasms syndrome who were on a ketogenic diet (KD) had severe hepatic steatosis, which could be prevented by a specific probiotic blend. These probiotics protected the liver by improving signaling pathways and promoting lipid oxidation, potentially reducing the risk of hepatic side effects in children receiving KD treatment.
Article
Nutrition & Dietetics
Ji Won Kwak, Yong Jae Lee, Byoungjin Park, Dong Hyuk Jung
Summary: This study investigated the risk of ischemic heart disease (IHD) in individuals with elevated CEA levels, hepatic steatosis, and their co-occurrence. The results showed that the co-occurrence of elevated CEA levels and hepatic steatosis increases the risk of IHD.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Carlos Perez-Monter, Alejandro Alvarez-Arce, Natalia Nuno-Lambarri, Ivonne Escalona-Nandez, Eva Juarez-Hernandez, Norberto C. Chavez-Tapia, Misael Uribe, Varenka J. Barbero-Becerra
Summary: Supplementing inulin in a classic obesity and fatty liver model mice can effectively prevent hepatic steatosis and reshape the composition of intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J Shyy
Summary: Elevated levels of Ch25h and its enzymatic product 25-HC alleviate HFD-induced hepatic steatosis by regulating enterohepatic circulation of bile acids, involving 25-HC activation of CYP7A1 via liver X receptor. Targeting Ch25h or 25-HC may have therapeutic advantages against nonalcoholic fatty liver disease.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Critical Care Medicine
Runzhi Huang, Tong Meng, Qiongfang Zha, Kebin Cheng, Xin Zhou, Junhua Zheng, Dingyu Zhang, Ruilin Liu
Summary: This study identified CEA as the only laboratory indicator significantly associated with prognosis in COVID-19 patients. Analysis of single-cell transcriptome data revealed the potential role of CEA in lungs and peripherals in the progression of COVID-19.
Article
Cell Biology
Pei-Yao Liu, Cheng-Cheung Chen, Chia-Ying Chin, Te-Jung Liu, Wen-Chiuan Tsai, Jian-Liang Chou, Chuan-Yu Huang, Yu-Guang Chen, Ying-Chuan Chen
Summary: This study found that the upregulated expression of GRAIL gene in the liver of NAFLD patients, and Grail knockout significantly alleviated hepatic fat accumulation induced by a high-fat diet. Conversely, overexpression of GRAIL exacerbated lipid accumulation. The results demonstrated that Grail regulates hepatic steatosis through interaction with sirtuin 1, showing its significance as a molecular regulator in the development of NAFLD.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Lu Xu, Zhe Huang, Tak-ho Lo, Jimmy Tsz Hang Lee, Ranyao Yang, Xingqun Yan, Dewei Ye, Aimin Xu, Chi-Ming Wong
Summary: The activation of the PRMT1/HNF-4α/PGC-1α signaling pathway may serve as a potential therapeutic strategy for combating non-alcoholic fatty liver disease in obese individuals.
Article
Multidisciplinary Sciences
Maria-Carolina Rodriguez-Daza, Laurence Daoust, Lemia Boutkrabt, Genevieve Pilon, Thibault Varin, Stephanie Dudonne, Emile Levy, Andre Marette, Denis Roy, Yves Desjardins
SCIENTIFIC REPORTS
(2020)
Editorial Material
Gastroenterology & Hepatology
Benjamin A. H. Jensen, Andre Marette
Review
Endocrinology & Metabolism
Beatrice S. -Y. Choi, Laurence Daoust, Genevieve Pilon, Andre Marette, Angelo Tremblay
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Nutrition & Dietetics
Marion Valle, Philippe St-Pierre, Genevieve Pilon, Andre Marette
Article
Immunology
Stephane Isnard, John Lin, Brandon Fombuena, Jing Ouyang, Thibault V. Varin, Corentin Richard, Andre Marette, Rayoun Ramendra, Delphine Planas, Laurence Raymond Marchand, Meriem Messaoudene, Claude P. Van der Ley, Ido P. Kema, Darakhshan Sohail Ahmed, Yonglong Zhang, Malcolm Finkelman, Bertrand Routy, Jonathan Angel, Petronela Ancuta, Jean-Pierre Routy
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Geriatrics & Gerontology
Mohamed-Salah Annabi, Marine Clisson, Marie-Ange Fleury, Martine Voisine, Maxime Hervault, Mylene Shen, Anne-Julie Boilard, Andre Marette, Geraldine Ong, Nancy Cote, Marie-Annick Clavel
EXPERIMENTAL GERONTOLOGY
(2020)
Article
Nutrition & Dietetics
Lais Rossi Perazza, Noemie Daniel, Marie-Julie Dubois, Genevieve Pilon, Thibault Vincent Varin, Mylene Blais, Jose Luis Martinez Gonzales, Michael Bouchard, Claude Asselin, Martin Lessard, Yves Pouliot, Denis Roy, Andre Marette
JOURNAL OF NUTRITION
(2020)
Article
Chemistry, Medicinal
Alan Ramalho, Nadine Leblanc, Marie-Gil Fortin, Andre Marette, Andre Tchernof, Helene Jacques
Article
Nutrition & Dietetics
Marion Regnier, Marialetizia Rastelli, Arianne Morissette, Francesco Suriano, Tiphaine Le Roy, Genevieve Pilon, Nathalie M. Delzenne, Andre Marette, Matthias Van Hul, Patrice D. Cani
Article
Nutrition & Dietetics
Rachel Durand, Adia Ouellette, Vanessa P. Houde, Frederic Guenard, Thibaut V. Varin, Bruno Marcotte, Genevieve Pilon, Erwann Fraboulet, Marie-Claude Vohl, Andre Marette, Laurent Bazinet
Article
Biochemistry & Molecular Biology
Lais R. Perazza, Patricia L. Mitchell, Farah Lizotte, Benjamin A. H. Jensen, Philippe St-Pierre, Jocelyn Trottier, Olivier Barbier, Patrick Mathieu, Pedro M. Geraldes, Andre Marette
Summary: The study shows that dietary intake of Omega-3 polyunsaturated fatty acids can prevent ESRD and cardiac dysfunction in diabetic mice, while PDX offers a potential new therapeutic strategy against ESRD by protecting against renal failure and cardiac dysfunction.
Article
Biochemistry & Molecular Biology
Maximilien Franck, Juan de Toro-Martin, Thibault V. Varin, Veronique Garneau, Genevieve Pilon, Denis Roy, Patrick Couture, Charles Couillard, Andre Marette, Marie-Claude Vohl
Summary: Numerous studies have found that diets rich in phenolic compounds are beneficial for immune-metabolic health, but the effects vary among individuals and the mechanisms are not well understood. This study used transcriptomic analysis to identify two subgroups of responders and non-responders to raspberry consumption based on whole-blood RNAseq data. Responders showed a significant decrease in triglycerides, cholesterol, and C-reactive protein levels, and had distinct gene expression and microbiota profiles compared to non-responders. The transcriptomic approach used in this study provides a promising framework for understanding the inter-individual variability in the impact of foods on immune-metabolic health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Maximilien Franck, Juan De Toro-Martin, Thibault V. Varin, Veronique Garneau, Genevieve Pilon, Denis Roy, Patrick Couture, Charles Couillard, Andre Marette, Marie-Claude Vohl
Summary: This study evaluated the gut microbial signatures of different TMAO responses following raspberry consumption. The results showed that raspberry consumption altered the gut microbial composition, which in turn affected the changes in TMAO levels.
Article
Infectious Diseases
Paul B. L. George, Florent Rossi, Magali-Wen St-Germain, Pierre Amato, Thierry Badard, Michel G. Bergeron, Maurice Boissinot, Steve J. Charette, Brenda L. Coleman, Jacques Corbeil, Alexander Culley, Marie-Lou Gaucher, Matthieu Girard, Stephane Godbout, Shelley P. Kirychuk, Andre Marette, Allison McGeer, Patrick T. O'Shaughnessy, E. Jane Parmley, Serge Simard, Richard J. Reid-Smith, Edward Topp, Luc Trudel, Maosheng Yao, Patrick Brassard, Anne-Marie Delort, Araceli D. Larios, Valerie Letourneau, Valerie E. Paquet, Marie-Helene Pedneau, Emilie Pic, Brooke Thompson, Marc Veillette, Mary Thaler, Ilaria Scapino, Maria Lebeuf, Mahsa Baghdadi, Alejandra Castillo Toro, Amelia Belanger Cayouette, Marie-Julie Dubois, Alicia F. Durocher, Sarah B. Girard, Andrea Katherin Carranza Diaz, Asmaa Khalloufi, Samantha Leclerc, Joanie Lemieux, Manuel Perez Maldonado, Genevieve Pilon, Colleen P. Murphy, Charly A. Notling, Daniel Ofori-Darko, Juliette Provencher, Annabelle Richer-Fortin, Nathalie Turgeon, Caroline Duchaine
Summary: Antimicrobial resistance (AMR) is a growing global problem that affects public health, agriculture, and the environment. The mechanism of aerial transport of antimicrobial-resistant bacteria via bioaerosols is not well understood. This ongoing project in Canada aims to assess the presence and fate of AMR in bioaerosols, including the emissions of antibiotic resistance genes, their long-distance transport, and dissemination models. A multidisciplinary approach is necessary to understand the role of bioaerosols in the spread of AMR.
Article
Nutrition & Dietetics
William Gagnon, Veronique Garneau, Jocelyn Trottier, Melanie Verreault, Charles Couillard, Denis Roy, Andre Marette, Jean-Philippe Drouin-Chartier, Marie-Claude Vohl, Olivier Barbier
Summary: This study analyzed the impact of dietary supplementation with blueberry powder on the composition of fecal bile acids (BA). The results showed that the consumption of blueberry powder led to significant increases in glycine-conjugated BAs, glycochenodeoxycholic acid, and glycoursodeoxycholic acid, as well as a significant reduction in secondary BA levels.