Article
Biochemistry & Molecular Biology
Leah J. Elias, Isabella K. Succi, Melanie D. Schaffler, William Foster, Mark A. Gradwell, Manon Bohic, Akira Fushiki, Aman Upadhyay, Lindsay L. Ejoh, Ryan Schwark, Rachel Frazer, Brittany Bistis, Jessica E. Burke, Victoria Saltz, Jared E. Boyce, Anissa Jhumka, Rui M. Costa, Victoria E. Abraira, Ishmail Abdus-Saboor
Summary: By studying mice, it is found that sensory neurons labeled by Mrgprb4 are able to detect mechanical stimulation and play a crucial role in sexual receptivity and dopamine release. Optogenetic stimulation of these neurons can induce a conditioned place preference and a copulatory posture even in social isolation. In the absence of Mrgprb4-lineage neurons, female mice no longer find male mounts rewarding and show aggression instead.
Article
Biochemistry & Molecular Biology
Amit Banik, Juneyong Eum, Byung Joon Hwang, Yun Kee
Summary: This study comprehensively explores the neurotoxic implications of dithianon on humans and wildlife using zebrafish larvae as a model. The research finds that dithianon induces behavioral alterations and disrupts cellular and mitochondrial homeostasis. It also regulates the expression levels of different neuronal markers in a concentration-dependent manner.
Article
Multidisciplinary Sciences
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Summary: This study reveals the mechanisms underlying the homeostatic estrogen negative feedback pathway and demonstrates the crucial role of estradiol-dependent plasticity in pulse generator synchronization events. The study also provides experimental evidence that estrogen receptor alpha in hypothalamic kisspeptin neurons is the principal pathway for estrogen negative feedback in mice.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Marios C. Panayi, Thomas Boerner, Thomas Jahans-Price, Anna Huber, Rolf Sprengel, Gary Gilmour, David J. Sanderson, Paul J. Harrison, Mark E. Walton, David M. Bannerman
Summary: Psychosis in disorders like schizophrenia is associated with aberrant salience and elevated striatal dopamine. The cause of this hyper-dopaminergic state is unknown. Deficits in glutamatergic function and synaptic plasticity may contribute to schizophrenia, including deficits associated with the GluA1 AMPAR subunit. This study shows that GluA1 dysfunction, resulting in impaired short-term habituation, is a key driver of enhanced striatal dopamine responses, which may contribute to aberrant salience and psychosis in psychiatric disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Hannah Bertels, Guillem Vicente-Ortiz, Khadija El Kanbi, Aya Takeoka
Summary: Adult spinal cord injury switches neurotransmitter phenotype from excitation to inhibition, while neonatal spinal cord injury maintains the excitatory phenotype. Maintaining excitatory phenotype is crucial for locomotor recovery.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Ines Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Summary: Coupling the release of pituitary hormones to the developmental stage of the oocyte is crucial for female fertility. In this study, the researchers found that estrogen plays a role in restraining and activating different regions of the hypothalamus to control the activity of KISS1-neuron and the expression of Kiss1 gene. These findings provide mechanistic insights into how estrogen regulates fertility in females.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Robert Porteous, Patricia Haden, Eleni C. R. Hackwell, Aaron Singline, Michel K. Herde, Reena Desai, David J. Handelsman, David R. Grattan, Allan E. Herbison
Summary: Recent research has utilized the tail-tip bleeding approach in mice to analyze the pulsatile and surge profiles of luteinizing hormone secretion. The PULSAR algorithm has been reformulated to operate on modern computer systems, allowing for more accurate analysis of pulsatile LH secretion in mice and the establishment of a realistic model of estrogen negative feedback.
Article
Endocrinology & Metabolism
Robert Porteous, Patricia Haden, Eleni C. R. Hackwell, Aaron Singline, Michel K. Herde, Reena Desai, David J. Handelsman, David R. Grattan, Allan E. Herbison
Summary: The recent use of the tail-tip bleeding approach in mice has allowed researchers to generate detailed pulse and surge profiles of luteinizing hormone (LH) secretion, leading to the reformulation of the PULSAR algorithm for analyzing pulsatile LH secretion and establishing an accurate model of estrogen negative feedback in mice.
Article
Biochemistry & Molecular Biology
J. Rudolph Starrett, Suzanne M. Moenter
Summary: Gonadal steroid feedback regulates the secretion of GnRH, with negative feedback modulating the amplitude and frequency of GnRH pulses and positive feedback inducing a surge pattern of GnRH release. Kisspeptin-expressing neurons in the arcuate nucleus and anteroventral periventricular area are thought to mediate these feedback mechanisms and patterns of GnRH secretion.
Article
Multidisciplinary Sciences
Pamela S. Del Fresno, DarIo C. Colautti, Gustavo E. Berasain, Leandro A. Miranda
Summary: The study describes the gonadal stages of pejerrey in Gomez Lake, showing a relationship between gonadal development, gonadosomatic index, sexual steroids, and temperature. Females start ovulating in winter, while males continue sperm production throughout the spawning season.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Article
Critical Care Medicine
J. Walker Wiggins, Natalie Kozyrev, Jonathan E. Sledd, George G. Wilson, Lique M. Coolen
JOURNAL OF NEUROTRAUMA
(2019)
Article
Endocrinology & Metabolism
Daichi Kayo, Yoshitaka Oka, Shinji Kanda
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Justin A. Lopez, Elizabeth C. Bowdridge, Richard B. McCosh, Michelle N. Bedenbaugh, Ashley N. Lindo, Makayla Metzger, Megan Haller, Michael N. Lehman, Stanley M. Hileman, Robert L. Goodman
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Editorial Material
Neurosciences
Hollis Cline, Lique Coolen, Saskia de Vries, Steven Hyman, Rosalind Segal, Oswald Steward
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Danielle T. Porter, Robert L. Goodman, Stanley M. Hileman, Michael N. Lehman
Summary: The study found that there were higher numbers of vGlut2 inputs onto KNDy neurones in sheep during the follicular phase with high levels of estradiol. This suggests that the synaptic plasticity of glutamatergic inputs to KNDy neurones depends on increasing levels of estradiol during the ovine follicular phase. These synaptic changes likely contribute to the positive-feedback action of estrogen on GnRH/LH secretion and the generation of the preovulatory surge in sheep.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Physiology
Yoichi Kasahara, Masataka Narukawa, Yoshiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe, Tomiko Asakura
Summary: The study reveals that TMC4 acts as a chloride channel responding to high-concentration NaCl in the oral cavity, facilitating the permeation of organic anions and showing a weaker glossopharyngeal nerve response in Tmc4-deficient mice compared to wild-type littermates.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Soma Tomihara, Yoshitaka Oka, Shinji Kanda
Summary: Behavioral analysis plays a crucial role in biological studies, but manual behavioral recordings are laborious and prone to human-errors. By establishing an open-source behavioral recording system using Raspberry Pi, automated video-recording and file-sorting are achieved, reducing human errors significantly. Additionally, with the development of an Excel macro, behavioral annotation becomes easier and more efficient.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Chie Umatani, Nagisa Yoshida, Eri Yamamoto, Yasuhisa Akazome, Yasutaka Mori, Shinji Kanda, Kataaki Okubo, Yoshitaka Oka
Summary: Animals use multiple sensory cues to perform sexual behaviors, but the neural mechanisms behind integrating these cues and regulating motivation for sexual behaviors are not well understood. This study focuses on TN-GnRH neurons, which co-express NPFF and GnRH3, and demonstrates their role in modulating certain neuronal circuits for controlling behavioral motivation. Specifically, NPFF activates neurons in the preoptic area, leading to an increase in motivation for male sexual behaviors. These findings contribute to our understanding of the functional significance of peptidergic neuromodulation in response to sensory information from the external environments.
Review
Endocrinology & Metabolism
Robert L. Goodman, Allan E. Herbison, Michael N. Lehman, Victor M. Navarro
Summary: This article discusses the neural mechanisms underlying the episodic and surge secretion of GnRH, with a focus on the core components. Recent studies have revealed that the arcuate nucleus kisspeptin neurons, also known as KNDy cells, and their projections to GnRH dendrons serve as the GnRH pulse generator in mice and rats. Similar roles have been observed in sheep and goats, but the evidence is weaker in monkeys and humans. In spontaneous ovulators, the core endocrine signal for GnRH/luteinising hormone surge is an increase in estradiol secretion, with species variations in the neural trigger.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kana Ikegami, Sho Kajihara, Chie Umatani, Mikoto Nakajo, Shinji Kanda, Yoshitaka Oka
Summary: Using a non-mammalian model of medaka, it was found that 17 beta-estradiol could promote the upregulation of GnRH1 neuronal activity, triggering the GnRH surge, and the combined action of estrogen and time signals is crucial for triggering ovulation at the appropriate time.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Satoshi Ogawa, Naoyuki Yamamoto, Hanako Hagio, Yoshitaka Oka, Ishwar S. Parhar
Summary: Three paralogous genes for GnRH and GnRH receptors exist in non-mammalian vertebrates. The migration of GnRH neurons in the brain is evolutionally conserved across different species. Each GnRH system has distinctive anatomical and physiological characteristics, and functions differently based on their origin and expression patterns.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Michael N. Lehman
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Rebecca E. Campbell, Lique M. Coolen, Gloria E. Hoffman, Erik Hrabovszky
Summary: The anatomy and morphology of GnRH neurons present both joy and challenges in research. Understanding their anatomy is crucial for understanding reproductive function regulation, and comparative aspects exist in different species. Future research needs to address unanswered questions.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Michael N. Lehman
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Danielle T. Porter, Aleisha M. Moore, Jade A. Cobern, Vasantha Padmanabhan, Robert L. Goodman, Lique M. Coolen, Michael N. Lehman