Article
Endocrinology & Metabolism
Stefan Groeneweg, Ferdy S. van Geest, Zhongli Chen, Stefania Farina, Ramona E. A. van Heerebeek, Marcel E. Meima, Robin P. Peeters, Heike Heuer, Marco Medici, W. Edward Visser
Summary: The study demonstrates that SLC17A4 facilitates the transport of T3 and T4, as well as less efficiently rT3 and 3,3’-T2. Further research should reveal the physiological role of SLC17A4 in TH regulation.
Article
Plant Sciences
Nelzo C. Ereful, Huw Jones, Nick Fradgley, Lesley Boyd, Hirut Assaye Cherie, Matthew J. Milner
Summary: Significant genetic and phenotypic variation was found in Ethiopian tef varieties, indicating the potential for breeding nutritional traits of importance to human health.
Article
Endocrinology & Metabolism
Ferdy S. van Geest, Marcel E. Meima, Kyra E. Stuurman, Nicole Wolf, Marjo S. van der Knaap, Claudia F. Lorea, Fabiano O. Poswar, Filippo Vairo, Nicola Brunetti-Pierri, Gerarda Cappuccio, Priyanka Bakhtiani, Sonja A. de Munnik, Robin P. Peeters, W. Edward Visser, Stefan Groeneweg
Summary: Genetic variants in the SLC16A2 gene can cause MCT8 deficiency, leading to intellectual and motor disabilities as well as abnormal thyroid function tests. Variants affecting the intracellular C-terminal tail of MCT8 are likely benign unless they cause frameshifts that elongate the MCT8 protein. These findings provide clinical guidance in assessing the pathogenicity of variants within the C-terminal domain of MCT8.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Zhongli Chen, Robin P. Peeters, Wesley Flach, Linda J. de Rooij, Sena Yildiz, Alexander Teumer, Matthias Nauck, Rosalie B. T. M. Sterenborg, Joost H. W. Rutten, Marco Medici, W. Edward Visser, Marcel E. Meima
Summary: This study identifies a novel group of transporters for (sulfated) iodothyronines in the organic anion transporter (OAT) subfamily of solute carrier (SLC) 22 family. These transporters play a critical role in the uptake of thyroid hormones and further research is needed to understand their relevance in thyroid hormone homeostasis and physiology.
EUROPEAN THYROID JOURNAL
(2023)
Article
Oncology
Min Joon Lee, Viranda H. Jayalath, Wei Xu, Lin Lu, Stephen J. Freedland, Neil E. Fleshner, Girish S. Kulkarni, Antonio Fineni, Theodorus H. van Der Kwast, Robert J. Hamilton
Summary: The relationship between metformin use and prostate cancer risk is controversial, with metformin use associated with increased risk of high-grade and overall prostate cancer. SNPs involved in metformin metabolism did not modify disease risk association, but two SNPs from the GWAS study did.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Cell Biology
Xiaoting Chen, Mian Wu, Nan Liang, Junxi Lu, Shen Qu, Haibing Chen
Summary: The study found that serum urate levels are influenced by free T3 in gout patients, and levels can increase following treatment with triiodothyronine. Triiodothyronine promotes uric acid production by regulating the Period2 gene, enhancing the binding of thyroid hormone receptor-beta, and ultimately affecting uric acid levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edward York, Daniel A. Mcnaughton, Meryem-Nur Duman, Philip A. Gale, Tristan Rawling
Summary: It has been discovered that bisaryl urea compounds can mediate mitochondrial uncoupling, leading to inhibition of breast cancer cell growth. Furthermore, substituting the urea group in bisaryl ureas can alter the activity of the compounds, with different substituents yielding different effects.
Article
Endocrinology & Metabolism
Bingyang Liu, Zixiao Wang, Jinrong Fu, Haixia Guan, Zhaohui Lyu, Wei Wang
Summary: This study found that decreased central sensitivity to thyroid hormones is associated with a lower risk of prediabetes, demonstrating a complex interaction between the thyroid system and glucose metabolism. Future studies are needed to confirm these findings and determine the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Theresa Porst, Joerg Johannes, Hans Gluschke, Richard Koehler, Sebastian Mehl, Peter Kuehnen, Kostja Renko, Waldemar B. Minich, Susanna Wiegand, Lutz Schomburg
Summary: The study found that MCT8-aAb and MCT10-aAb are prevalent in thyroid disease and obesity, with the highest prevalence of MCT8-aAb in thyroid patients. Serum with positive MCT8-aAb can impact T4 uptake in cell culture.
Article
Oncology
Tae-Hwan Kim, Mi Yeon Lee, Sung Min Jin, Sang Hyuk Lee
Summary: The impact of serum thyroid hormone levels on thyroid cancer risk is still uncertain. This study found that low levels of TSH in men and high levels of TSH in women were associated with thyroid cancer. Additionally, high levels of free T4 and free T3 were also linked to thyroid cancer incidence.
ENDOCRINE-RELATED CANCER
(2022)
Article
Endocrinology & Metabolism
Zhongli Chen, A. S. Elise van der Sman, Stefan Groeneweg, Linda Johanna de Rooij, W. Edward Visser, Robin P. Peeters, Marcel E. Meima
Summary: Using pharmacological inhibitors, this study identified that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears to be independent of known TH transporters, suggesting the presence of alternative transporter(s) that are currently unknown.
Article
Environmental Sciences
Liguo Qiu, Shuhui Wei, Yunsheng Wang, Rui Zhang, Shaoguo Ru, Xiaona Zhang
Summary: This study found that BPS affects the visual function of zebrafish larvae and stimulates the metabolism of all-trans-retinoic acid. By modulating the expression of CYP26A1 and TRO, it was found that CYP26A1 plays a crucial role in the oxidative metabolism of atRA and regeneration of retinoids in the visual cycle, and TRO mediates cyp26a1 expression in zebrafish eyes.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Oncology
Alessio Basolo, Antonio Matrone, Rossella Elisei, Ferruccio Santini
Summary: The increasing knowledge of molecular mechanisms in cell signaling pathways has led to the discovery of tyrosine kinases, which can be targeted for anticancer therapy. Tyrosine kinase inhibitors block enzyme activity and inhibit the growth and spread of cancer, but can also cause thyroid dysfunction.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julian Peter Mueller, Dirk Gruendemann
Summary: In this study, it has been demonstrated that the ergothioneine transporter ETT does not transport nucleosides but efficiently transports gemcitabine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Georg Sebastian Hoenes, Ramona Gowry Sivakumar, Christoph Hoppe, Joerg Koenig, Dagmar Fuehrer, Lars Christian Moeller
Summary: MGL-3196 is a new thyromimetic agent that activates TR beta with high efficacy through specific transport by OATP1B1, leading to its hepatic thyromimetic action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Serena Lillo, Trine Rennebod Larsen, Leif Pennerup, Kirsten Ohm Kyvik, Jens Sondergaard, Steen Antonsen
Summary: While some interventions led to a decrease in the number of tests, there was no indication of improved adherence to guidelines. In some cases, these interventions may have resulted in underutilization of the test, and thus should be used with caution.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Neurosciences
Frederik Norregaard Pedersen, Lonny Stokholm, Frans Pouwer, Katrine Hass Rubin, Tunde Peto, Ulrik Frydkjaer-Olsen, Anne Suhr Thykjaer, Nis Andersen, Jens Andresen, Toke Bek, Morten La Cour, Steffen Heegaard, Kurt Hojlund, Ryo Kawasaki, Javad Nouri Hajari, Kirsten Ohm Kyvik, Caroline Schmidt Laugesen, Katja Christina Schielke, Rafael Simo, Jakob Grauslund
Summary: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Endocrinology & Metabolism
Evert F. S. van Velsen, Robin P. Peeters, Merel T. Stegenga, Uwe Mader, Christoph Reiners, F. J. van Kemenade, Tessa M. van Ginhoven, W. Edward Visser, Frederik Anton Verburg
Summary: This study explores the use of two-step age-based cutoffs to improve the TNM staging system for thyroid cancer. The findings suggest that using two-step age cutoffs of 45 and 50 years for papillary thyroid cancer (PTC) and 25 and 40 years for follicular thyroid cancer (FTC) may be slightly better in predicting disease-specific survival compared to the currently used single age cutoffs.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Dennis Vriens, Maarten O. van Aken, Lioe-Ting Dijkhorst-Oei, Wim J. G. Oyen, Robin P. Peeters, Abbey Schepers, Lioe-Fee De Geus-Oei, Wilbert B. van den Hout
Summary: This study evaluates the cost-effectiveness of an [F-18]FDG-PET/CT-driven diagnostic workup compared to diagnostic surgery for thyroid nodules with Bethesda III/IV cytology. The results show that [F-18]FDG-PET/CT avoids unnecessary diagnostic surgeries and reduces costs while maintaining quality of life.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Endocrinology & Metabolism
Rosalie B. T. M. Sterenborg, Tessel E. Galesloot, Alexander Teumer, Romana T. Netea-Maier, Doug Speed, Marcel E. Meima, W. Edward Visser, Johannes W. A. Smit, Robin P. Peeters, Marco Medici
Summary: This study identified novel genetic variants associated with thyroid-stimulating hormone (TSH) and thyroxine (FT4) concentrations through a large-scale candidate gene analysis. However, the candidate gene SNPs only explained a small portion of the variation in TSH and FT4 concentrations, highlighting the need for larger genetic studies to uncover novel pathways in thyroid hormone regulation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Karri Silventoinen, Weilong Li, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Sari Aaltonen, Maarit Piirtola, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Laura A. Baker, Catherine Tuvblad, Per Tynelius, Finn Rasmussen, Jeffrey M. Craig, Richard Saffery, Gonneke Willemsen, Meike Bartels, Catharina E. M. van Beijsterveldt, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Paul Lichtenstein, Robert F. Krueger, Matt McGue, Shandell Pahlen, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Kimberly J. Saudino, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Vilhelmina Ullemar, Catarina Almqvist, Patrik K. E. Magnusson, Robin P. Corley, Brooke M. Huibregtse, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Claire M. A. Haworth, Robert Plomin, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Glen E. Duncan, Dedra Buchwald, S. Alexandra Burt, Kelly L. Klump, Clare H. Llewellyn, Abigail Fisher, Dorret Boomsma, Thorkild I. A. Sorensen, Jaakko Kaprio
Summary: Using genetic twin design, this study analyzed the genetic correlations of BMI and height in children and adolescents, finding that the genetic correlations of BMI decreased with increasing age between assessments, especially from early to middle childhood, while the genetic correlations of height remained strong across all ages.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Medicine, General & Internal
Malene Grubbe Hildebrandt, Kristian Kidholm, Jorgen Ejler Pedersen, Mohammad Naghavi-Behzad, Torben Knudsen, Aleksander Krag, Jesper Ryg, Oke Gerke, Annmarie Touborg Lassen, Torkell Ellingsen, Henrik J. Ditzel, Vibeke Andersen, Annette Langhoff, Gert Nielsen, Tahir Masud, Anna-Marie Bloch Munster, Kirsten Kyvik, Kim Brixen
Summary: This article shares the initial experiences of implementing Lean thinking and visual management in hospital research units. Lean tools were found to help identify waste in work processes and should also focus on improving research quality and patient-related results.
Review
Endocrinology & Metabolism
Heba Alwan, Fanny Villoz, Martin Feller, Robin P. F. Dullaart, Stephan J. L. Bakker, Robin P. Peeters, Maryam Kavousi, Douglas C. Bauer, Anne R. Cappola, Bu B. Yeap, John P. Walsh, Suzanne J. Brown, Graziano Ceresini, Luigi Ferrucci, Jacobijn Gussekloo, Stella Trompet, Massimo Iacoviello, Jae Hoon Moon, Salman Razvi, Isabela M. Bensenor, Fereidoun Azizi, Atieh Amouzegar, Sergio Valdes, Natalia Colomo, Nick J. Wareham, J. Wouter Jukema, Rudi G. J. Westendorp, Ki Woong Kim, Nicolas Rodondi, Cinzia Del Giovane
Summary: This study conducted a systematic review and individual participant data analysis to investigate the association between subclinical thyroid dysfunction and incident diabetes. The results showed no clear association between subclinical thyroid dysfunction and the development of diabetes.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Evert F. S. van Velsen, Robin P. Peeters, Merel T. Stegenga, Folkert J. van Kemenade, Tessa M. van Ginhoven, Mathe van Balkum, Frederik A. Verburg, W. Edward Visser
Summary: This study compared the performance of different risk stratification systems in predicting disease-specific survival in patients with differentiated thyroid cancer. The optimized age-adjusted TNM system showed the best predictive value among all the systems.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
Rochus Neeleman, Kyra Musters, Margreet Wagenmakers, Sophie Mijnhout, Edith Friesema, Eric Sijbrands, Janneke Langendonk
Summary: This study estimates the all-cause mortality in pedigrees with HMBS gene variants that cause acute intermittent porphyria (AIP). The overall mortality was found to be similar to the general Dutch population, but there was excess mortality in certain age groups of women and men.
Article
Clinical Neurology
Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer Madsen, Axel Thielscher, Hartwig Roman Siebner, Messoud Ashina, Anders Hougaard
Summary: In this study, we compared the distances between visual cortical areas and overlying dura mater in female patients with migraine aura without headache and female patients with migraine aura with headache. The results showed no significant differences in distances or volumes between the two groups. Therefore, we conclude that there may not be a direct connection between migraine aura and headache.
Article
Public, Environmental & Occupational Health
Christine Stabell Benn, Nelly Amenyogbe, Anders Bjorkman, Jorge Dominguez-Andres, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby
Summary: The current framework for testing and regulating vaccines needs to be updated to consider the non-specific effects of vaccines, which can affect all-cause mortality and morbidity in ways that are not explained by the prevention of the targeted disease. Immunological studies have provided mechanisms that explain how vaccines might modulate the immune response to unrelated pathogens. Non-specific effects are often greater in female individuals. Currently, these effects are not routinely captured in clinical trials or post-licensure safety surveillance, but a new framework is proposed to address this issue.
Article
Genetics & Heredity
Warren van Loggerenberg, Shahin Sowlati-Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Dayag Sheykhkarimli, Marinella Gebbia, Nishka Kishore, Laure Fresard, Sami Mustajoki, Elena Pischik, Elena Di Pierro, Michela Barbaro, Ylva Floderus, Caroline Schmitt, Laurent Gouya, Alexandre Colavin, Robert Nussbaum, Edith C. H. Friesema, Raili Kauppinen, Jordi To-Figueras, Aasne K. Aarsand, Robert J. Desnick, Michael Garton, Frederick P. Roth
Summary: This study introduces a new method to evaluate the functional impact of HMBS variants, providing a tool to distinguish pathogenic from benign variants and assisting in clinical diagnosis.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Serena Lillo, Trine Rennebod Larsen, Kirsten Ohm Kyvik, Jens Sondergaard, Steen Antonsen
Summary: GPs in the Region of Southern Denmark were randomly assigned to interventions aimed at maximizing their use of Vitamin D tests. A survey study was conducted to examine GPs' assessment of these interventions. The results showed that guidelines were found helpful by half of the GPs and feedback reports were often read. Pop-up alerts were accepted for frequently used tests, but there were concerns about the interruptive alert appearing every time a Vitamin D test was requested.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
