Article
Biochemistry & Molecular Biology
Kalpana Patel, S. V. V. S. Ravi Mangu, Shinde Vijay Sukhdeo, Kunal Sharan
Summary: This study investigates the effects of sesamol on bone metabolism. It found that sesamol can promote bone formation but can also lead to bone deterioration in ovariectomized rats. These findings highlight the potential negative impact of sesamol in postmenopausal women.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Iryna Khrystoforova, Chen Shochat-Carvalho, Ram Harari, Katrin Henke, Katherine Woronowicz, Matthew P. P. Harris, David Karasik
Summary: This study investigated the role of LRP5 in skeletal development and homeostasis using a gene knockout zebrafish model. Transcriptome analysis revealed upregulation of genes associated with hydrolase activity in lrp5 mutants, indicating changes in osteoclast differentiation. Functional analysis showed increased resorptive activity in the absence of Lrp5 signaling, potentially leading to skeletal dysmorphologies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hantao Yao, Yangge Du, Bulin Jiang, Yilin Liao, Yaoyu Zhao, Mengjie Yin, Ting Li, Yue Sheng, Yaoting Ji, Minquan Du
Summary: Inflammatory disorders induce bone loss through osteoclast differentiation. LFS effectively inhibits osteoclast formation by suppressing AKT phosphorylation and promoting NRF2 expression and translocation, thus combating oxidative stress and bone loss. LFS holds promise as a therapeutic agent for oxidative-stress related diseases and bone loss disorders.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I. Idris
Summary: Research on the modulation of CB1 and CB2 receptors on bone metabolism has shown that the results are confounded by the heterogeneity of models and the low number of studies.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Qi Zhuang, Shuangshuang Chen, Wei Zhang, Minhui Gu, Long Xiao, Yajun Li, Yunshang Yang, Chengcheng Feng, Hong Li, Dechun Geng, Zhirong Wang
Summary: Osteoporosis is characterized by bone loss and degeneration, leading to an increased risk of fractures and impacting the health of middle-aged and elderly individuals. Drug therapy, the main treatment for osteoporosis, is limited in efficacy and often associated with side effects. Therefore, developing new, effective, and safe treatment methods is crucial. Avicularin, a flavonoid derivative, was shown to disrupt osteoclast activation and resorptive function, preventing their activity. It achieved this by inhibiting the NF-kappa B pathway and downregulating osteoclast-related genes. Treatment with Avicularin also improved bone mineral density in an osteoporosis mouse model.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Jin Ah Ryuk, Hyunil Ha
Summary: The water extract of Lophatherum gracile leaves inhibits osteoclast differentiation and bone loss, making it a potential candidate for therapy and prevention of postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Melanie Aureal, Irma Machuca-Gayet, Fabienne Coury
Summary: Rheumatoid arthritis is characterized by chronic synovial inflammation and irreversible bone erosions. Osteoclast-mediated bone resorption is the main cause of articular bone erosions, with autoantibodies, pro-inflammatory cytokines, and other regulating factors playing important roles in this process.
Article
Microbiology
Wei Li, Chuan Wei, Lei Xu, Beibei Yu, Ying Chen, Di Lu, Lina Zhang, Xian Song, Liyang Dong, Sha Zhou, Zhipeng Xu, Jifeng Zhu, Xiaojun Chen, Chuan Su
Summary: Infection with schistosome can result in immunological changes that influence the skeletal system, inducing abnormal bone metabolism and bone loss. Studies using a mouse model of chronic schistosomiasis showed that schistosome infection leads to osteoclast-mediated bone loss, accompanied by changes in RANKL and OPG levels. Blocking RANKL can prevent bone loss in the context of schistosome infection, with B cells and CD4(+) T cells, especially Tfh cell subset, identified as important cellular sources of RANKL during schistosome infection. These findings emphasize the risk of bone loss in schistosome-infected patients and the potential benefits of combining bone therapy with anti-schistosome treatment.
Article
Multidisciplinary Sciences
Su-Hyeon Cho, Seongsin Lee, Jae-Il Park, Yoon La Yang, Song-Rae Kim, Juhee Ahn, Hoibin Jeong, Hye-Yeon Jung, Nayoung Gwak, Kil-Nam Kim, Yumi Kim
Summary: This study explores aging traits in turquoise killifish spines and finds that aged fish exhibit body shape deformations and increased vertebral collapse, similar to age-related spinal stenosis in humans. The study also identifies gene expression changes related to age and reproduction.
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Megan M. Weivoda, Elizabeth W. Bradley
Summary: Bone remodeling is crucial for maintaining bone quality by removing and replacing damaged and old bone. This process requires tight coordination between bone resorption and bone formation. Besides osteoclasts and osteoblasts, macrophages and other myeloid lineage cells have been found to support bone remodeling. This article discusses the origin and functions of macrophages in the bone microenvironment, including tissue resident macrophages, osteomacs, and newly identified osteomorphs resulting from osteoclast fission. The role of macrophages in inflammatory bone resorption is also touched upon.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xiaokang Jia, Huaichang Zhu, Gaopan Li, Mengliu Lan, Xiaoyan Li, Mingqing Huang, Wen Xu, Shuisheng Wu
Summary: Alisol C 23-acetate (AC23A) derived from Alismatis rhizoma (AR) has anti-inflammatory and metabolic disease ameliorating effects, and shows inhibitory effects on osteoclastogenesis in vitro and in vivo by suppressing RANKL-induced osteoclast differentiation and function, suggesting its potential in preventing or limiting bone diseases mediated by osteoclasts.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Xin Zhou, Zheng Zhang, Weiwei Jiang, Miao Hu, Yichen Meng, Wenfang Li, Xuhui Zhou, Ce Wang
Summary: Naringenin, found in citrus fruits, plays a significant role in bone homeostasis and regeneration by enhancing osteogenesis and inhibiting osteoclastogenesis. It modulates the crosstalk between macrophages and osteoblasts/osteoclasts, leading to these effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Ciro Menale, Elisabetta Campodoni, Eleonora Palagano, Stefano Mantero, Marco Erreni, Antonio Inforzato, Elena Fontana, Francesca Schena, Rob van't Hof, Monica Sandri, Anna Tampieri, Anna Villa, Cristina Sobacchi
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Endocrinology & Metabolism
Kerensa M. Beekman, Annegreet G. Veldhuis-Vlug, Martin den Heijer, Mario Maas, Ania M. Oleksik, Michael W. Tanck, Susan M. Ott, Rob J. van't Hof, Paul Lips, Peter H. Bisschop, Nathalie Bravenboer
Article
Rheumatology
Ioannis Kanakis, Ke Liu, Blandine Poulet, Behzad Javaheri, Rob J. van't Hof, Andrew A. Pitsillides, George Bou-Gharios
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Engineering, Biomedical
J. Renwick Beattie, Antonia Sophocleous, M. Clare Caraher, Olive O'Driscoll, Niamh M. Cummins, Steven E. J. Bell, Mark Towler, Alireza Rahimnejad Yazdi, Stuart H. Ralston, Aymen I. Idris
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2019)
Article
Endocrinology & Metabolism
Silvia Marino, Ryan T. Bishop, Giovana Carrasco, John G. Logan, Boya Li, Aymen I. Idris
CALCIFIED TISSUE INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Barry Shaw, Carla L. Burrell, Darrell Green, Ana Navarro-Martinez, Daniel Scott, Anna Daroszewska, Rob van 't Hof, Lynn Smith, Frank Hargrave, Sharad Mistry, Andrew Bottrill, Benedikt M. Kessler, Roman Fischer, Archana Singh, Tamas Dalmay, William D. Fraser, Kirstin Henneberger, Turi King, Silvia Gonzalez, Robert Layfield
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Rheumatology
Lianzhi Chen, Felix Yao, Tao Wang, Guangyi Li, Peilin Chen, Max Bulsara, Jessica Jun Yi Zheng, Euphemie Landao-Bassonga, Marty Firth, Praveen Vasantharao, Yigang Huang, Michelle Lorimer, Stephen Graves, Junjie Gao, Richard Carey-Smith, John Papadimitriou, Changqing Zhang, David Wood, Christopher Jones, Minghao Zheng
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Endocrinology & Metabolism
Silvia Marino, Giovana Carrasco, Boya Li, Karan M. Shah, Darren L. Lath, Antonia Sophocleous, Michelle A. Lawson, Aymen I. Idris
CALCIFIED TISSUE INTERNATIONAL
(2020)
Article
Oncology
Ryan T. Bishop, Silvia Marino, Giovana Carrasco, Boya Li, Richard J. Allen, Anna Sparatore, Penelope D. Ottewell, Patrick Mollat, Andrew H. Sims, Mattia Capulli, Ning Wang, Aymen I. Idris
Article
Cell & Tissue Engineering
Brent Allan, Rui Ruan, Euphemie Landao-Bassonga, Nicholas Gillman, Tao Wang, Junjie Gao, Yonghua Ruan, Yuan Xu, Clair Lee, Mithran Goonewardene, Minghao Zheng
Summary: Treatment of cortical bone defects is a clinical challenge. In this study, a new type I collagen membrane for guided bone regeneration (GBR) has been clinically translated. The collagen membrane acts in an osteoconductive manner to facilitate cortical bone regeneration and improve cortical bone repair significantly, both in preclinical animal study and clinical trial. CelGro collagen membrane shows promise for GBR in both dental and orthopedic applications.
TISSUE ENGINEERING PART A
(2021)
Article
Cell & Tissue Engineering
Peilin Chen, Ziming Chen, Christopher Mitchell, Junjie Gao, Lianzhi Chen, Allan Wang, Toby Leys, Euphemie Landao-Bassonga, Qiujian Zheng, Tao Wang, Minghao Zheng
Summary: Intramuscular injection of Botox interferes with tendon homeostasis by inducing tendon atrophy and senescence of tendon-derived stem cells (TDSCs). This may have long-term adverse consequences for the treatment of tendinopathy.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
David Mellis, Katherine A. Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H. Ralston, Donald M. Salter, Natalia A. Riobo-Del Galdo, Robert E. Hill, Mark Ditzel
Summary: The mammalian Hedgehog (HH) signalling pathway is crucial for tissue homeostasis, with UBR5 being identified as a regulator in maintaining cartilage homeostasis and suppressing metaplasia. Loss of Ubr5 function results in severe articular cartilage degradation, abnormal bone formation, and extensive tissue metaplasia. Additionally, Ubr5 interacts with smoothened to regulate the HH pathway and increase PKA activity, highlighting its important role in musculoskeletal system regulation.
Article
Orthopedics
Peilin Chen, Allan Wang, William Haynes, Euphemie Landao-Bassonga, Clair Lee, Rui Ruan, William Breidahl, Behzad Shiroud Heidari, Christopher A. Mitchell, Minghao Zheng
Summary: This study evaluated a bioactive collagen scaffold (BCS) for its structural and biological properties, as well as the feasibility and safety of using it for augmenting tendon repair. Results showed that BCS supports tendon stem cell growth and aids in tendon regeneration, indicating potential application in RC repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Cell Biology
Katie J. Lee, Lisa Rambault, George Bou-Gharios, Peter D. Clegg, Riaz Akhtar, Gabriela Czanner, Rob van't Hof, Elizabeth G. Canty-Laird
Summary: The study found that mice lacking the alpha 2(I) chain do not exhibit impaired bone biomechanical or structural properties like oim homozygous mice. However, male mice from both lines were affected in terms of Mendelian inheritance, and male mice null for the alpha 2(I) chain showed age-related loss of condition. Compound heterozygotes had impaired bone structural properties compared to oim heterozygotes, but to a lesser extent than oim homozygotes, suggesting a genetic interaction between homotrimeric type I collagen and the oim mutant allele leads to bone fragility.
DISEASE MODELS & MECHANISMS
(2022)
Article
Multidisciplinary Sciences
Pei Ying Ng, Amy B. P. Ribet, Qiang Guo, Benjamin H. Mullin, Jamie W. Y. Tan, Euphemie Landao-Bassonga, Sebastien Stephens, Kai Chen, Jinbo Yuan, Laila Abudulai, Maike Bollen, Edward T. T. T. Nguyen, Jasreen Kular, John M. Papadimitriou, Kent Soe, Rohan D. Teasdale, Jiake Xu, Robert G. Parton, Hiroshi Takayanagi, Nathan J. Pavlos
Summary: Using organelle-resolution proteomics, the authors identified Slc37a2 as a sugar transporter in osteoclast secretory lysosomes. They found that Slc37a2 is required for the maintenance of skeletal bone mass and that its deficiency leads to high bone mass in mice. This study provides new insights into the molecular composition and spatiotemporal organization of secretory lysosomes in osteoclasts.
NATURE COMMUNICATIONS
(2023)