Article
Multidisciplinary Sciences
Amy K. Sutton, Paulette B. Goforth, Ian E. Gonzalez, James Dell'Orco, Hongjuan Pei, Martin G. Myers, David P. Olson
Summary: The study reveals that VMH neurons expressing melanocortin 3 receptor (Mc3R) can sense glucose changes and promote glucose utilization by regulating blood glucose levels. Activation of these neurons can attenuate glucose fluctuations, while silencing them enhances blood glucose excursions following a glucose load.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Caroline S. Johnson, Weizhe Hong, Paul E. Micevych
Summary: Research findings suggest that GABA neurons in the MeApd facilitate lordosis in female mice, while glutamate neurons may direct behavior away from social interactions. Photoinhibition of VGAT neurons decreased lordosis quotient (LQ), while photoexcitation of VGluT2 neurons increased time spent self-grooming, indicating different roles of GABA and glutamate in social and reproductive behaviors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Endocrinology & Metabolism
Berengere Coupe, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Penicaud, Tamas L. Horvath, Sebastien G. Bouret
Summary: The study investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the ventromedial nucleus of the hypothalamus (VMH) under normal and fasting conditions. It was found that autophagy is nutritionally regulated in VMH neurons and participates in controlling energy homeostasis during fasting.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Feng-Ling Wu, Si-Hai Chen, Jia-Ni Li, Liu-Jie Zhao, Xue-Mei Wu, Jie Hong, Ke-Hua Zhu, Han-Xue Sun, Su-Juan Shi, E. Mao, Wei-Dong Zang, Jing Cao, Zhen-Zhen Kou, Yun-Qing Li
Summary: This study investigated the role of zona incerta (ZI) in nociceptive neurotransmission. A projection pathway from the rostral ZI (ZIR) to the thalamic paraventricular nucleus (PVT) was found to be involved in nociceptive modulation. Activation of the ZIR-PVT pathway alleviated pain, while inhibiting the circuit induced hypersensitivity. Furthermore, GABA-A receptor was found to be crucial for the inhibitory effect from ZIR to PVT.
Article
Biochemistry & Molecular Biology
Polina A. Anfimova, Lydia G. Pankrasheva, Konstantin Yu Moiseev, Elizaveta S. Shirina, Valentina V. Porseva, Petr M. Masliukov
Summary: The hypothalamus plays a crucial role in regulating homeostasis, biological rhythms, adaptation, and aging. This study found the presence of Lin28-immunoreactive neurons in the ventromedial nucleus of the hypothalamus and their absence in other studied nuclei. The percentage of Lin28-positive neurons increases with age, peaks at 6 months and 1 year, and then declines. These neurons also colocalize components of insulin signaling, indicating their involvement in metabolic regulation. The findings suggest that Lin28 expression in the hypothalamus changes with development and signaling components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Pauline Bohne, Achim Volkmann, Martin K. Schwarz, Melanie D. Mark
Summary: This study found that deletion of the P/Q-type calcium channel from serotonergic neurons in the dorsal raphe nuclei (DRN) increases aggressive behavior in male mice, while anxiety is not affected. The study also confirmed a neural projection from the DRN to the ventrolateral part of the ventromedial hypothalamus, and inhibiting these projections effectively reduces aggressive behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Teodora Georgescu, Zin Khant Aung, David R. Grattan, Rosemary S. E. Brown
Summary: Aggressive behavior is observed in lactating female mice and is controlled by prolactin receptor in the ventromedial nucleus (VMN), which affects other brain regions involved in maternal behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Tuanjie Huang, Fangxia Guan, Julio Licinio, Ma-Li Wong, Yunlei Yang
Summary: This study reveals that the neuropeptide oxytocin increases anxiety by activating OXTr neurons in the septal region of the brain, which project inhibitory GABA inputs to the horizontal diagonal band of Broca (HDB). The activation of these pathways induces anxiety-like behaviors, shedding light on the complex role of oxytocin in modulating emotions.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Haixing Zhong, Huamin Xu, Xin Li, Rou-gang Xie, Yunxin Shi, Ying Wang, Li Tong, Qianqian Zhu, Jing Han, Huiren Tao, Li Zhang, Zhian Hu, Xia Zhang, Ning Gu, Hailong Dong, Xufeng Xu
Summary: The ventromedial prefrontal cortex (vmPFC) plays a role in regulating sleep and wakefulness by controlling the activity of dorsomedial hypothalamus (DMH) neurons. Stimulation of vmPFC neurons promotes wakefulness and suppresses non-REM sleep (NREM), while stimulating vmPFC projections in DMH produces opposite effects.
Article
Neurosciences
Xu Wang, Haohong Li
Summary: This study found that synaptic remodeling, lipid droplet accumulation, and synaptic dysfunction occur in feeding-related brain regions of obese mice induced by high-fat diet. These impairments are associated with energy homeostasis and reward regulation, which may contribute to overeating in obesity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Anna Fosch, Sebastian Zagmutt, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: SF1 neurons in the ventromedial hypothalamus play a crucial role in sensing glucose levels and mediating insulin and leptin signaling, as well as in energy expenditure and glucose homeostasis, particularly in the early stages of obesity. While studies have provided insight into the central role of these neurons in whole-body energy homeostasis, they have also raised new questions regarding the existence of neuronal sub-populations and the complexity of neurocircuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Musa Iyiola Ajibola, Jei-Wei Wu, Wahab Imam Abdulmajeed, Cheng-Chang Lien
Summary: The study demonstrates that subcortical input from the SuM selectively regulates the activities of different DG neurons through distinct synaptic mechanisms in mice. While SuM activation leads to synaptic excitation and inhibition in all post-synaptic cells, the ratio of these components varies depending on cell type. Specifically, dendrite-targeting interneurons primarily receive synaptic excitation, soma-targeting interneurons and granule cells mainly receive synaptic inhibition.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Ross A. McDevitt, Rosa Anna M. Marino, Hugo A. Tejeda, Antonello Bonci
Summary: Serotonin plays a crucial role in cue-reward learning in mice, as serotonin reuptake inhibitors can reduce lever pressing behavior, and alterations in serotonin levels in different brain regions can impact behavioral responses.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Obstetrics & Gynecology
Anne Hammer, Anne F. Rositch, Johnny Kahlert, Patti E. Gravitt, Jan Blaakaer, Mette Sogaard
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Oncology
David J. Riedel, Anne F. Rositch, Robert R. Redfield, William A. Blattner
LEUKEMIA & LYMPHOMA
(2016)
Article
Obstetrics & Gynecology
Michelle I. Silver, Anne F. Rositch, Anne E. Burke, Katie Chang, Raphael Viscidi, Patti E. Gravitt
OBSTETRICS AND GYNECOLOGY
(2015)
Article
Oncology
David J. Riedel, Anne F. Rositch, Robert R. Redfield
INFECTIOUS AGENTS AND CANCER
(2015)
Article
Infectious Diseases
David J. Riedel, Lydia S. Tang, Anne F. Rositch
CURRENT HIV/AIDS REPORTS
(2015)
Meeting Abstract
Oncology
A. L. Beavis, P. E. Gravitt, A. F. Rositch
GYNECOLOGIC ONCOLOGY
(2016)
Review
Oncology
Anne Hammer, Anne Rositch, Fares Qeadan, Patti E. Gravitt, Jan Blaakaer
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Infectious Diseases
Eleni Marie Rettig, Carole Fakhry, Anne F. Rositch, Anne E. Burke, Kathryn Chang, Michelle I. Silver, Raphael Viscidi, Patti Gravitt
SEXUALLY TRANSMITTED DISEASES
(2016)
Editorial Material
Public, Environmental & Occupational Health
Anne F. Rositch, Melinda Krakow
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2018)
Review
Public, Environmental & Occupational Health
J. Ting, A. F. Rositch, S. M. Taylor, L. Rahangdale, H. M. Soeters, X. Sun, J. S. Smith
EPIDEMIOLOGY AND INFECTION
(2015)
Review
Obstetrics & Gynecology
Anna Jo Bodurtha Smith, Sanskriti Varma, Anne F. Rositch, Kimberly Levinson
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Christina A. Chao, Liuye Huang, Kala Visvanathan, Kisa Mwakatobe, Nestory Masalu, Anne F. Rositch
Article
Oncology
Patti E. Gravitt, Anne F. Rositch, Magdalena Jurczuk, Graciela Meza, Lita Carillo, Jose Jeronimo, Prajakta Adsul, Laura Nervi, Margaret Kosek, J. Kathleen Tracy, Valerie A. Paz-Soldan
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Immunology
Anna L. Beavis, Kristin Meek, Meghan B. Moran, Laura Fleszar, Sarah Adler, Anne F. Rositch
Summary: This study investigated the perceptions of vaccine-hesitant parents of children aged 10-17 who were not vaccinated against HPV. The study found that parents lacked confidence in vaccine decision-making and desired more information. They were also dissatisfied with the encounters they had with healthcare providers.
Article
Oncology
Mark Parascandola, Gila Neta, Ramzi G. Salloum, Donna Shelley, Anne F. Rositch
Summary: This paper discusses the importance and role of local evidence when transferring interventions or implementation strategies from high-income countries to low- and middle-income countries.
JCO GLOBAL ONCOLOGY
(2022)