Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shuyu Li, Heng Pei, Yaomeng Huang, Da Liu, Liqun Yang, Qi Zhang, Zhijun Wang
Summary: An animal model of atrial fibrillation was constructed to observe the effect of acute atrial fibrillation on renal water and sodium metabolism in mice. The expression of TGF-beta and type III collagen in atrial myocardium, as well as the levels of CRP and IL-6 in blood, were examined. Additionally, the protein expression of NF-kappa B, TGF-beta, type III collagen, AQP2, AQP3, ENaC-beta, ENaC-gamma, SGK1, and NKCC in the kidneys were observed. The results showed that acute atrial fibrillation led to renal inflammatory response and fibrosis, hindering water and sodium metabolism, which was associated with the up-regulation of NKCC, ENaC, and AQPs in the kidneys.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Maurizio Forte, Simona Marchitti, Flavio Di Nonno, Rosita Stanzione, Leonardo Schirone, Maria Cotugno, Franca Bianchi, Sonia Schiavon, Salvatore Raffa, Danilo Ranieri, Salvatore Fioriniello, Floriana Della Ragione, Maria Rosaria Torrisi, Roberto Carnevale, Valentina Valenti, Francesco Versaci, Giacomo Frati, Carmine Vecchione, Massimo Volpe, Speranza Rubattu, Sebastiano Sciarretta
Summary: NPPA plays a critical role in the cardiovascular system by activating autophagy to protect cardiomyocytes, reduce cardiac fibrosis, and promote vascular integrity.
Article
Cardiac & Cardiovascular Systems
Shang-Feng Yang, Szu-Yuan Li, Feng-Yen Lin, Tsung-Han Hsieh, Po-Hsun Huang, Shing-Jong Lin
Summary: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease. This study found that in CKD patients, levels of corin are increased in the heart and serum, but its activity is suppressed. These findings suggest that corin dysfunction may play a significant role in the pathogenesis of CKD-associated cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Physiology
Marcelo Roberto Choi, Belisario Enrique Fernandez
Summary: Atrial natriuretic peptide, part of the natriuretic peptide family, has natriuretic, diuretic, and vasodilator effects that oppose the renin-angiotensin system. It also exerts nephroprotective effects due to its antioxidant and anti-inflammatory properties, making it a beneficial agent against acute and chronic kidney diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carina Ureche, Gianina Dodi, Adela Mihaela Serban, Andreea Simona Covic, Luminita Voroneanu, Simona Hogas, Radu Andy Sascau, Cristian Statescu, Adrian Covic
Summary: Patients with chronic kidney disease have an increased risk of death, and collagen biomarkers such as PICP may be valuable in predicting mortality in ESRD patients.
Article
Multidisciplinary Sciences
Cristina Perez-Ternero, Aisah A. Aubdool, Raj Makwana, Gareth J. Sanger, Roland H. Stimson, Li F. Chan, Amie J. Moyes, Adrian J. Hobbs
Summary: C-type natriuretic peptide (CNP) plays a crucial role in lipid homeostasis and energy balance by regulating the expression of uncoupling protein-1 and lipid utilization. CNP exerts these metabolic regulatory actions by inhibiting sympathetic thermogenic programming and reducing peroxisome proliferator-activated receptor-gamma coactivator-1 alpha expression, while driving adipogenesis via NPR-B/protein kinase-G.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Markus Hahn, Ulrike M. Stamer, Markus M. Luedi, Malte Book, Heinz U. Rieder, Frank Stueber
Summary: Plasma concentrations of natriuretic peptides (NP) are important for risk stratification and management of patients undergoing non-cardiac surgery. This study found that genetic variability in NP levels might influence plasma concentrations. Inclusion of genetic information could improve perioperative risk stratification for patients.
Review
Urology & Nephrology
Sidar Copur, Atalay Demiray, Carlo Basile, Mehmet Kanbay
Summary: Acute kidney injury (AKI) is a common comorbidity and can have a considerable impact on the endocrine system. The effects on various parameters have been extensively studied, but the endocrinological consequences of AKI are understudied. This review aims to illustrate what is known and what is not known about the endocrinological outcomes of AKI, emphasizing the need for large-scale trials.
JOURNAL OF NEPHROLOGY
(2023)
Article
Hematology
Marco Basset, Paolo Milani, Andrea Foli, Mario Nuvolone, Pietro Benvenuti, Martina Nanci, Francesca Fabris, Claudia Bellofiore, Giampaolo Merlini, Giovanni Palladini
Summary: This study evaluated the impact of early cardiac response on the outcome of patients with newly diagnosed stage IIIb cardiac AL amyloidosis, and found that early cardiac response resulted in longer survival.
Review
Biochemical Research Methods
Meysam Gachpazan, Arash Mohammadinejad, Amin Saeidinia, Hamid Reza Rahimi, Majid Ghayour-Mobarhan, Farveh Vakilian, Majid Rezayi
Summary: Heart disease poses a serious threat to human health globally, leading to rising mortality rates. B-type natriuretic peptide is a crucial biomarker for diagnosis of heart failure, but faces challenges such as low concentration and short half-life in blood.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Sarah J. Fitzsimons, Jonathan D. W. Evans, Doris M. Rassl, Kuan Ken Lee, Fiona E. Strachan, Jayan Parameshwar, Nicholas L. Mills, Stephen J. Pettit
Summary: This study aimed to investigate whether a new high-sensitivity cardiac troponin I (hs-cTnI) assay could be used as a rule-out test for acute cellular rejection (ACR) after heart transplantation. The results showed no association between hs-cTnI concentration and the presence of significant ACR on surveillance endomyocardial biopsy, indicating that measurement of hs-cTnI may not be a useful technique for diagnosis or exclusion of ACR after heart transplantation.
Article
Food Science & Technology
Shuai Liu, Xintao Gao, Yulan Yin, Jing Wang, Kehong Dong, Dayong Shi, Xiaochen Wu, Chuanlong Guo
Summary: Silk fibroin peptide nanofibers loaded with naringenin protected kidney cells from cisplatin-induced damage by activating mitophagy and inhibiting mtDNA release and the cGAS-STING pathway. This study confirmed the potential of silk fibroin peptide nanofibers for protection against cisplatin-induced acute kidney injury, warranting further investigation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jia-Jin Chen, Tao Han Lee, George Kuo, Yen-Ta Huang, Pei-Rung Chen, Shao-Wei Chen, Huang-Yu Yang, Hsiang-Hao Hsu, Ching-Chung Hsiao, Chia-Hung Yang, Cheng-Chia Lee, Yung-Chang Chen, Chih-Hsiang Chang
Summary: This study evaluated the effectiveness of various pharmacological and non-pharmacological strategies for preventing acute kidney injury (AKI) after cardiac surgery through a network meta-analysis. Nine potentially effective strategies were identified, with natriuretic peptide therapy being the most effective pharmacological strategy and remote ischemic preconditioning being the only effective non-pharmacological strategy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Susumu Tsuda, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Naoki Haruyama, Akiko Fukui, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono
Summary: This study found that subclinical hypothyroidism (SCH) is independently associated with poor renal outcomes in chronic kidney disease (CKD) patients, suggesting that screening for SCH might be needed for accurate prediction of renal prognosis.