Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Article
Immunology
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee
Summary: The study revealed that GnRH vaccine can reduce hormone concentrations, lead to testicular atrophy and decreased sperm quality, and have an impact on animal mating and reproductive abilities.
Review
Chemistry, Medicinal
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma
Summary: This review discusses the usage, administration, and impact on serum testosterone levels of GnRH receptor agonists and antagonists, focusing on the mechanism of action of the antagonists and their development in clinical studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Tracy A. Burnett, Augusto M. L. Madureira, Janet W. Bauer, Ronaldo L. A. Cerri
Summary: This study found that administration of GnRH at the time of artificial insemination can improve fertility in cows with reduced estrous expression, but increased ovulation rate does not seem to be the direct mechanism behind this relationship.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lisa-Marie Sattler, Hanna A. Schniewind, Waldemar B. Minich, Christoph W. Haudum, Petra Niklowitz, Julia Muenzker, Gabor L. Kovacs, Thomas Reinehr, Barbara Obermayer-Pietsch, Lutz Schomburg
Summary: In European adult control groups and PCOS patients, only a very small fraction have natural GnRH-R-aAb. Our results do not support the hypothesis that GnRH-R is a significant autoantigen in PCOS.
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
M. H. C. Pereira, B. I. Cappellozza, R. L. A. Cerri, C. P. Sanches Jr, T. G. Guida, L. F. S. P. Barbosa, J. E. P. Santos, J. L. M. Vasconcelos
Summary: This study evaluated the use of a second PGF(2 alpha) treatment in improving pregnancy rates of lactating Holstein cows undergoing timed embryo transfer. The results showed that the use of a second PGF(2 alpha) treatment increased estrus expression and ovulation rates, but did not affect pregnancy rates.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Neurosciences
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo
Summary: The absence of the p140Cap gene in mice leads to abnormalities in fertility, puberty development, and hormone secretion. This may be due to its role in the development of the hypothalamic gonadotropic system and modulation of glutamatergic signaling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Andrology
Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa
Summary: The recovery patterns of hormonal profiles after short-term (12 weeks) neoadjuvant ADT differ between GnRH antagonists and GnRH agonists. The choice between these drugs matters and may have a clinical impact depending on the primary objective of ADT.
Article
Geriatrics & Gerontology
Dorota Walkiewicz, Zofia Wicik, Monika Puzianowska-Kuznicka
Summary: The study identified pathways associated with age-related changes in human B lymphocytes, including the gonadotropin-releasing hormone receptor (GnRHR) pathway, which is involved in both aging and lymphocyte activation. Inhibition of the GnRHR pathway reduced cell proliferation, increased apoptosis, and led to decreased immunoglobulin G synthesis in B lymphocytes, with a more pronounced effect in centenarian cells compared to young cells.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Seifollah Gholampour, Mehrnoosh Bahmani
Summary: The study compared the efficiency of shunt placement and endoscopic third ventriculostomy (ETV) in treating adult hydrocephalus patients with varying intensities and obstruction levels in the Sylvius aqueduct.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Georgia Biniari, Christos Markatos, Agathi Nteli, Haralambos Tzoupis, Carmen Simal, Alexios Vlamis-Gardikas, Vlasios Karageorgos, Ioannis Pirmettis, Panagiota Petrou, Maria Venihaki, George Liapakis, Theodore Tselios
Summary: Gonadotropin-releasing hormone (GnRH) plays a key role in regulating human reproduction and fertility. GnRH receptor type I (GnRHR I), expressed on both healthy and cancer cells, is a potential target for anti-cancer drugs. This study synthesized a series of anthraquinone/mitoxantrone-GnRH conjugates and found promising results in terms of binding affinity and potential for further pharmacological evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Parviz Heidari, Mahdi Entazari, Amin Ebrahimi, Mostafa Ahmadizadeh, Alessandro Vannozzi, Fabio Palumbo, Gianni Barcaccia
Summary: The study investigated the effects of 24-epi-brassinolide (EBR) as analogs of brassinosteroids (BRs) on tomato plants under low-temperature stress, revealing that EBR treatment can increase hormone content and transcription of cold-responsive genes, ultimately improving cold resistance. The findings suggest that EBR may decrease oxidative stress and increase antioxidant enzymes, leading to improved growth rate in tomatoes under low-temperature conditions.