Article
Endocrinology & Metabolism
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill
Summary: This study found that the sexual behavior of female MC4R knockout mice lacking melanocortin 4 receptors (MC4Rs) was altered. Further research revealed that the expression of MC4Rs in Sim1 neurons could restore sexual responsivity in female mice, while its expression in oxytocin neurons could improve sexual receptivity. These results suggest that MC4R signaling in oxytocin neurons is involved in appetitive behaviors, while MC4R signaling in Sim1 neurons plays a role in female sexual receptivity, indicating that melanocortin-driven sexual function does not rely on metabolic neural circuits.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Steven A. Hill, Marissa Fu, A. Denise R. Garcia
Summary: Astrocytes are complex cells performing essential functions in the nervous system. The Sonic hedgehog (Shh) signaling pathway plays a crucial role in regulating the molecular identity and functional properties of astrocytes, and is active in specific subpopulations of these cells throughout the brain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hanan Khaled Sleiman, Jeane Maria de Oliveira, Guilherme Barroso Langoni de Freitas
Summary: Isoflavones are a group of plant compounds that have similar structures to endogenous hormones and may affect the development and functioning of the reproductive system. They have both beneficial and harmful effects, which can be influenced by factors such as type and exposure period.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Behavioral Sciences
Raymundo Dominguez-Ordonez, Marcos Garcia-Juarez, Sandra Tapia-Hernandez, Ailyn Luna-Hernandez, Miriam Eli Galindo-Madrid, Miriam B. Tecamachaltzi-Silvaran, Kurt L. Hoffman, James G. Pfaus, Oscar Gonzalez-Flores
Summary: The study investigated the involvement of the Oxytocin/Prostaglandin E2/GnRH pathway in the facilitation of lordosis behavior induced by OT in rats. Results showed that blocking OT receptor, COX2, EP4 prostaglandin receptor, or GnRH-1 receptor inhibited OT-induced lordosis behavior, suggesting a direct involvement of hypothalamic astrocytes.
HORMONES AND BEHAVIOR
(2021)
Review
Medicine, Research & Experimental
Peiyi Li, Qing Yu, Huimin Nie, Chengyu Yin, Boyi Liu
Summary: Pain is a major characteristic of many diseases and chronic pain burdens patients physically and mentally. Current medications for chronic pain are sometimes inefficient and may cause side effects. IL-33/ST2 signaling plays an important role in regulating pain in both immune and somatosensory systems and is also involved in chronic itch. Targeting IL-33/ST2 signaling holds promise for the management of pain and itch.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Youmei Huang, Liping Liu, Mengnan Chai, Han Su, Suzhuo Ma, Kaichuang Liu, Yaru Tian, Zhuangyuan Cao, Xinpeng Xi, Wenhui Zhu, Jingang Qi, Ravishankar Palanivelu, Yuan Qin, Hanyang Cai
Summary: This study found that two epigenetic factors, SWR1 and SDG2, genetically interact with the ER signaling pathway to regulate female germline development in Arabidopsis, restricting the fate of megaspore mother cells and promoting the protein accumulation of BZR1 transcription factor family to activate the expression of primary miRNA processing factors. This research provides new insights into understanding the Gene Regulation Network involved in female germline development.
Article
Cell Biology
Manman Liang, Lijing Wang, Zhengui Sun, Xingwu Chen, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Summary: This study reveals that TRIM15 is frequently upregulated in NSCLC and associated with poor prognosis. Functionally, TRIM15 promotes proliferation and metastasis of NSCLC cells through its E3 ubiquitin ligase activity. Mechanistically, TRIM15 directly targets Keap1 and promotes its ubiquitination and degradation, resulting in the escape of Nrf2 from Keap1-mediated degradation, subsequently promoting antioxidant response and tumor progression.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Mario Villa-Gonzalez, Gerardo Martin-Lopez, Maria Jose Perez-Alvarez
Summary: This review provides recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, focusing on cerebral ischemia. It covers the upstream and downstream pathways regulating mTOR complex activation and summarizes recent advances in understanding mTORC1 and mTORC2 status in ischemia-hypoxia at tissue and cellular levels, particularly in glial and neural cells. The potential use of mTORC1 and mTORC2 as therapeutic targets after stroke is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Ming Li, Xin Zhang, Lefei Jiao, Jinlin Wang, Yu He, Shuqin Li, Min Jin, Lu Zhang, Qicun Zhou
Summary: The accumulation of nutrients in the gonads is closely related to the reproductive capacity and quality of larvae in the subsequent autotrophic stage of Litopenaeus vannamei. Dietary protein levels significantly affect the composition of amino acids in the ovary, stages of ovarian development, and gene expression related to vitellogenin. A diet with 52.81% protein content promotes ovarian development and plays a role in the synthesis, transport, and metabolic regulation of vitellogenin.
AQUACULTURE REPORTS
(2023)
Article
Neurosciences
Fuyuko Takata-Tsuji, Naura Chounlamountri, Le-Duy Do, Camille Philippot, Julia Novion Ducassou, Yohann Coute, Sarrah Ben Achour, Jerome Honnorat, Christophe Place, Olivier Pascual
Summary: Vesicular release plays a crucial role in neurotransmission, with neurons releasing neurotransmitters rapidly and synchronously, while astrocytes modulate neurotransmission through the slower release of various transmitters. Microglia regulate astrocytic gliotransmission by influencing SNARE proteins, impacting the kinetics and overall release of gliotransmitters by astrocytes. This interaction between microglia and astrocytes may have implications for central nervous system diseases involving microglial activation.
Review
Clinical Neurology
Gloria Kim, Xuan Chen, Yongjie Yang
Summary: Extracellular vesicles (EVs) have emerged as an important mechanism for intercellular communication, particularly in the central nervous system (CNS). EVs are classified as plasma membrane-derived microvesicles (MVs) and endosome-derived exosomes. They play a role in neural development, neuron communication, and propagation of disease protein aggregates. However, understanding their physiological and pathological roles, as well as their potential as biomarkers or therapeutics, still present significant challenges.
Article
Immunology
Wei Huang, Hao Tang, Yang Liu, WenWei Li, Ajmeri Sultana Shimu, BoFeng Li, Chen Zhu
Summary: This study found that ROR1 expression was significantly increased in the cartilage tissues of osteoarthritis (OA) patients. Knockdown of ROR1 alleviated activation of the NF-KB signaling pathway, reversed the suppression of collagen II and aggrecan by Wnt5a, and upregulated ADAMTS-5 and MMP-13 in chondrocytes. In addition, ROR1 knockdown significantly reduced Wnt5a-induced STAT3 nuclear translocation. Therefore, increased expression of ROR1 in OA cartilage tissues can form a positive feedback loop with STAT3, activating the NF-KB signaling pathway and resulting in an imbalance in chondrocyte metabolism.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Jue Wang, Nanning Sheng, Ying Li, Yawei Fan, Xinrong Nan, Rong Fu
Summary: Overexpression of Ly6D contributes to chemoresistance in laryngeal squamous cell carcinoma (LSCC) cells, while silencing Ly6D abolishes this phenotype. Activation of the Wnt/beta-catenin pathway is involved in Ly6D-mediated chemoresistance. Ly6D overexpression attenuates the expression of miR-509-5p, which unleashes CTNNB1 to activate Wnt/beta-catenin pathway and promote chemoresistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biology
Tao Wang, Biyang Jing, Bowen Deng, Kai Shi, Jing Li, Baoxu Ma, Fengming Wu, Chuan Zhou
Summary: In this study, the researchers identified a neuropeptide pathway in fruit flies that interacts with a central neural node to modulate female sexual receptivity. They found that the Cholecystokinin-like peptide Drosulfakinin (DSK) acts through its receptor CCKLR-17D3 and its expressing neurons to promote female sexual behavior. This discovery sheds light on the molecular and circuit mechanisms underlying female sexual behavior.
Article
Cell Biology
Yiran Liang, Yajie Wang, Yan Zhang, Fangzhou Ye, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Zekun Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Through analysis of the TCGA and GEO databases, it was found that heat shock protein beta-1 (HSPB1) was upregulated in breast cancer tissues and associated with poor prognosis of breast cancer patients, which was considered an independent prognostic factor. HSPB1 could promote cancer growth and metastasis, and enhance doxorubicin resistance by protecting breast cancer cells from ferroptosis. Additionally, HSPB1 overexpression led to increased secretion of IL6, which further facilitated breast cancer progression.
CELL DEATH & DISEASE
(2023)
Review
Endocrinology & Metabolism
Alejandro Lomniczi, Hollis Wright, Sergio R. Ojeda
FRONTIERS IN NEUROENDOCRINOLOGY
(2015)
Article
Multidisciplinary Sciences
Alejandro Lomniczi, Hollis Wright, Juan Manuel Castellano, Valerie Matagne, Carlos A. Toro, Suresh Ramaswamy, Tony M. Plant, Sergio R. Ojeda
NATURE COMMUNICATIONS
(2015)
Review
Endocrinology & Metabolism
C. A. Toro, C. F. Aylwin, A. Lomniczi
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Carlos A. Toro, Hollis Wright, Carlos F. Aylwin, Sergio R. Ojeda, Alejandro Lomniczi
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Johanna K. Mueller, Ines Koch, Alejandro Lomniczi, Alberto Loche, Tomke Rulfs, Juan M. Castellano, Wieland Kiess, Sergio Ojeda, Sabine Heger
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2012)
Article
Neurosciences
Alejandro Lomniczi, Alberto Loche, Juan Manuel Castellano, Oline K. Ronnekleiv, Martha Bosch, Gabi Kaidar, J. Gabriel Knoll, Hollis Wright, Gerd P. Pfeifer, Sergio R. Ojeda
NATURE NEUROSCIENCE
(2013)
Article
Endocrinology & Metabolism
Juan Manuel Castellano, Hollis Wright, Sergio R. Ojeda, Alejandro Lomniczi
NEUROENDOCRINOLOGY
(2014)
Article
Agriculture, Dairy & Animal Science
G. A. Dissen, A. Lomniczi, R. L. Boudreau, Y. H. Chen, B. L. Davidson, S. R. Ojeda
REPRODUCTION IN DOMESTIC ANIMALS
(2012)
Article
Endocrinology & Metabolism
Carlos Francisco Aylwin, Katinka Vigh-Conrad, Alejandro Lomniczi
NEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
David Lopez-Rodriguez, Delphine Franssen, Julie Bakker, Alejandro Lomniczi, Anne-Simone Parent
Summary: This article discusses the potential long-term reproductive consequences of perinatal exposure to endocrine-disrupting chemicals, focusing on the cellular and molecular impacts under neuroendocrine control. Exposure to EDCs during critical development periods may affect brain development, pubertal timing, and the female ovulatory cycle, ultimately leading to impaired fertility.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Hollis Wright, Carlos F. Aylwin, Carlos A. Toro, Sergio R. Ojeda, Alejandro Lomniczi
Summary: The research demonstrates that EED plays a crucial role in the arcuate nucleus of the hypothalamus by repressing the expression of Kdm6b to increase H3K27me3 abundance at gene promoters, thereby reducing gene expression in a gene network controlling puberty activation.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Carlos Farkas, Aracelly Quiroz, Claudia Alvarez, Viviana Hermosilla, Carlos F. Aylwin, Alejandro Lomniczi, Ariel F. Castro, Matias I. Hepp, Roxana Pincheira
Summary: The SALL2 transcription factor is evolutionarily conserved and plays a role in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, with a focus on cancer. Different studies suggest either a tumor suppressor or oncogenic role for SALL2, depending on the cancer type. Tissue-dependent expression of SALL2 isoforms and the need for further research on isoform-specific transcriptional targets and functions are highlighted.
FRONTIERS IN GENETICS
(2021)
Review
Endocrinology & Metabolism
Jesus Argente, Leo Dunkel, Ursula B. Kaiser, Ana C. Latronico, Alejandro Lomniczi, Leandro Soriano-Guillen, Manuel Tena-Sempere
Summary: Puberty, a major maturational event, is determined by genetic factors and influenced by endogenous and environmental cues. Research progress has been made in understanding the neuroendocrine networks governing puberty, but the precise timing and mechanisms of puberty and its alterations are still being deciphered. This review provides a comprehensive overview of the physiological basis of puberty, including the roles of kisspeptins and other central transmitters, the underlying molecular and endocrine mechanisms, and the pathways involved in pubertal modulation. Molecular features of precocious and delayed puberty are also summarized. The review highlights the need for further research in this active field of endocrinology.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Oncology
Tamara Carrizosa-Molina, Natalia Casillas-Diaz, Iris Perez-Nadador, Claudia Vales-Villamarin, Miguel Angel Lopez-Martinez, Rosa Riveiro-Alvarez, Larry Wilhelm, Rita Cervera-Juanes, Carmen Garces, Alejandro Lomniczi, Leandro Soriano-Guillen
Summary: This study identified 1672 differentially methylated CpGs and 48 differentially methylated regions between large for gestational age (LGA) and adequate for gestational age (AGA) newborns. Biological processes significantly enriched with genes in association with DMCs included regulation of transcription, epinephrine secretion, renal and cardiovascular development. Gene ontology analysis revealed enriched processes related to kidney development from the genes associated with the 48 DMRs. Furthermore, DNA methylation markers identified in this study are linked to biological pathways and rare diseases of the cardiovascular system, kidneys, and metabolism.
CLINICAL EPIGENETICS
(2023)
Article
Medicine, Research & Experimental
Ana Paula Abreu, Carlos A. Toro, Yong Bhum Song, Victor M. Navarro, Martha A. Bosch, Aysegul Eren, Joy N. Liang, Rona S. Carroll, Ana Claudia Latronico, Oline K. Ronnekleiv, Carlos F. Aylwin, Alejandro Lomniczi, Sergio Ojeda, Ursula B. Kaiser
JOURNAL OF CLINICAL INVESTIGATION
(2020)