Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer

Androgen signalling and steroid receptor crosstalk in endocrine cancers

(2014) Frank Claessens et al.   ENDOCRINE-RELATED CANCER

Estrogen receptor beta in prostate cancer: friend or foe?

(2014) Adam W Nelson et al.   ENDOCRINE-RELATED CANCER

Cardiovascular outcomes in patients with locally advanced and metastatic prostate cancer treated with luteinising-hormone-releasing-hormone agonists or transdermal oestrogen: the randomised, phase 2 MRC PATCH trial (PR09)

(2013) Ruth E Langley et al.   LANCET ONCOLOGY

Role of WNT7B-induced Noncanonical Pathway in Advanced Prostate Cancer

(2013) Dali Zheng et al.   MOLECULAR CANCER RESEARCH

Central Role for PELP1 in Nonandrogenic Activation of the Androgen Receptor in Prostate Cancer

(2012) Lin Yang et al.   MOLECULAR ENDOCRINOLOGY

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

(2012) Keith F. Decker et al.   NUCLEIC ACIDS RESEARCH

Insulin-like growth factor-I regulates GPER expression and function in cancer cells

(2012) P De Marco et al.   ONCOGENE

Life after failure of traditional androgen deprivation therapy

(2012) Paul Schellhammer   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Virotherapy induces massive infiltration of neutrophils in a subset of tumors defined by a strong endogenous interferon response activity

(2011) X Fu et al.   CANCER GENE THERAPY

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

GPR30 Activation Opposes Estrogen-Dependent Uterine Growth via Inhibition of Stromal ERK1/2 and Estrogen Receptor Alpha (ERα) Phosphorylation Signals

(2011) Fei Gao et al.   ENDOCRINOLOGY

Estrogens and Prostate Cancer: Etiology, Mediators, Prevention, and Management

(2011) Shuk-Mei Ho et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes

(2011) Anna Grazia Recchia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G-protein-coupled estrogen receptor GPER in health and disease

(2011) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

Abiraterone and Increased Survival in Metastatic Prostate Cancer

(2011) Johann S. de Bono et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17 -Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts

(2010) A. Madeo et al.   CANCER RESEARCH

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21 and induction of G2 cell-cycle arrest

(2010) Q K Y Chan et al.   CELL DEATH AND DIFFERENTIATION

Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion

(2010) Yuet-Kin Leung et al.   ENDOCRINE-RELATED CANCER

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

(2010) Johann Sebastian de Bono et al.   LANCET

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Do infantile testicular germ cell tumors histogenetically develop from conventional intratubular germ cell neoplasia?

(2010) Sven Gunia et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

(2009) Deo Prakash Pandey et al.   EMBO JOURNAL

The unfolding stories of GPR30, a new membrane-bound estrogen receptor

(2009) Marcello Maggiolini et al.   JOURNAL OF ENDOCRINOLOGY

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis

(2009) Eric Blasko et al.   JOURNAL OF NEUROIMMUNOLOGY

In vivo effects of a GPR30 antagonist

(2009) Megan K Dennis et al.   Nature Chemical Biology

Parenteral oestrogen in the treatment of prostate cancer: a systematic review

(2008) G Norman et al.   BRITISH JOURNAL OF CANCER

G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol

(2008) Christiane Otto et al.   ENDOCRINOLOGY

Epidermal Growth Factor Induces G Protein-Coupled Receptor 30 Expression in Estrogen Receptor-Negative Breast Cancer Cells

(2008) Lidia Albanito et al.   ENDOCRINOLOGY