Review
Oncology
Congxin Dai, Siyu Liang, Bowen Sun, Yong Li, Jun Kang
Summary: Refractory pituitary adenomas and pituitary carcinomas are difficult to treat, but anti-VEGF therapy is considered a promising alternative treatment. These tumors exhibit characteristics such as high Ki-67 index, rapid growth, frequent recurrence, and resistance to conventional treatments, and vascular endothelial growth factor plays a crucial role in these tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jie Zhou, Yaomin Hu, Wende Zhu, Chuansheng Nie, Wenxiu Zhao, Alexander T. Faje, Kay E. Labelle, Brooke Swearingen, Hang Lee, E. Tessa Hedley-Whyte, Xun Zhang, Pamela S. Jones, Karen K. Miller, Anne Klibanski, Yunli Zhou, Roy J. Soberman
Summary: This study found that angiogenesis in pituitary tumors is more active compared to normal pituitary gland tissue and is regulated mainly by PGF and VEGFC. The expression of endothelial markers in tumor samples was highly correlated with the expression of VEGFC and PGF. Inhibition of angiogenesis using VEGFR inhibitors showed promising results in vitro and in mice. Therefore, angiogenesis inhibitors may have potential as therapies for aggressive pituitary tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Giuseppe Giuffrida, Valeria D'Argenio, Francesco Ferrau, Vito Alessandro Lasorsa, Francesca Polito, Federica Aliquo, Marta Ragonese, Oana Ruxandra Cotta, Ylenia Alessi, Rosaria Oteri, Federica Di Maggio, Alessio Asmundo, Petronilla Daniela Romeo, Federica Spagnolo, Lucio Pastore, Filippo Flavio Angileri, Mario Capasso, Salvatore Cannavo, M'Hammed Aguennouz
Summary: The study found that there are complex epigenetic modifications, mainly methylation and miRNA activity, in pituitary adenomas. Nonfunctioning tumors (NFPAs) showed higher methylation levels compared to GH-omas, with 178 differentially methylated regions (DMRs) mainly located in noncoding and intronic sequences. Additionally, the study identified three hypermethylated genes involved in tumorigenesis processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Kaori Takeshita, Ichiro Abe, Wataru Kameda, Kota Ishii, Yuya Fujita, Mai Nagata, Kentaro Ochi, Yuki Senda, Midori Koga, Tadachika Kudo, Yurika Hada, Kaoru Takase, Yusuke Morinaga, Miiko Ito, Makiko Abe, Kenichi Ishizawa, Kunihisa Kobayashi
Summary: Pituitary apoplexy is a rare syndrome that often leads to spontaneous bleeding or infarction in pituitary tumors or glands. This study found that pituitary apoplexy occurs most frequently in patients with nonfunctional pituitary adenomas and is not related to tumor size. However, it is associated with hormonal deficiencies, liver dysfunction, hyponatremia or hypochloremia, and dyslipidemia.
Article
Oncology
Giulia Cossu, Stefano La Rosa, Jean Philippe Brouland, Nelly Pitteloud, Ethan Harel, Federico Santoni, Maxime Brunner, Roy Thomas Daniel, Mahmoud Messerer
Summary: The expression of PD-L1 is associated with proliferative grades of Trouillas' classification and specific subtypes of PitNET expressing growth hormone.
Article
Biochemistry & Molecular Biology
Grazia Maugeri, Agata Grazia D'Amico, Salvatore Saccone, Concetta Federico, Daniela Maria Rasa, Rosario Caltabiano, Giuseppe Broggi, Salvatore Giunta, Giuseppe Musumeci, Velia D'Agata
Summary: The study shows that PACAP plays a role in regulating the hypoxic micro-environment, angiogenesis and EMT in GBM cells. By inhibiting specific pathways and molecules, PACAP can reduce invasiveness of GBM cells and interfere with VEGF release and vessel formation. This study provides new insights into the complex role of PACAP in GBM malignancy.
Article
Oncology
Sherwin Tavakol, Michael P. Catalino, David J. Cote, Xian Boles, Edward R. Laws, Wenya Linda Bi
Summary: A novel classification scheme for cystic sellar lesions based on the heterogeneity of the cyst wall/contents and the presence of a solid component on imaging was proposed. The study found that different types of cysts were associated with the diagnoses of Rathke cleft cyst and cystic pituitary adenoma, with higher cyst types, fluid-fluid level presence, symptomatic hyperprolactinemia, and obesity being predictors of cystic pituitary adenoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhiyu Xi, Pamela S. Jones, Masaaki Mikamoto, Xiaobin Jiang, Alexander T. Faje, Chuansheng Nie, Kathryn E. Labelle, Yunli Zhou, Karen K. Miller, Roy J. Soberman, Xun Zhang
Summary: Aggressive pituitary adenomas have increased expression of PD-L2, CD80, and CD86 compared to normal pituitary glands, and significantly higher levels of CD80 and CD86 compared to non-aggressive tumors. These findings support further research on the potential role of immune checkpoint inhibition therapy in the treatment of pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Junyi Fu, Yanli Li, Lisha Wu, Xin Yang, Tingting Quan, Xi Li, Jiamin Zeng, Yinhui Deng, Jinxiu Yu
Summary: This study aimed to investigate the incidence, risk factors, and prognosis of pituitary hemorrhage in pituitary adenomas treated with gamma knife radiosurgery. It was found that nonfunctioning pituitary adenomas were an independent risk factor for new or worsened pituitary hemorrhage after gamma knife radiosurgery.
Review
Biochemistry & Molecular Biology
Samridhi Banskota, David C. Adamson
Summary: Pituitary adenomas are tumors that arise in the anterior pituitary gland, most commonly benign and exerting their effects through excess hormone secretion or mass effect. The clinical presentation varies based on the size and hormone secretion of the adenoma.
Article
Oncology
Chenran Zhang, Xiaoshu Dong, Weiwei Mao, Chen Wang, Bin Ma, Liuhua Hu, Ruoping Chen
Summary: The study reveals that hypoxia can up-regulate the expression and localization of glucocorticoid receptor, and HIF1α inhibitor can reduce tumor size and plasma concentrations of ACTH and corticosterone in an in-vivo mouse model of Cushing's disease.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yu Zhang, Lei Li, Xin Ma, Chenan Liu, Gemingtian Liu, Zhixu Bie, Zhijun Yang, Pinan Liu
Summary: The study found that SLC2A1 is a potential diagnostic marker for invasive pituitary adenoma and is closely related to EMT. Evaluation: 8 points.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Qizhi Zhang, Ying Wang, Yinting Zhou, Qiujuan Zhang, Chuan Xu
Summary: The abnormal expression of miRNAs has been closely linked to tumor development. This study found significantly lower levels of miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e in the peripheral serum of NFPA patients compared to normal subjects. These miRNAs may play a role in the occurrence and progression of NFPAs, providing a basis for further exploration of tumor markers in pituitary adenomas.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Lijie Dong, Wenbo Li, Tingting Lin, Boshi Liu, Yaru Hong, Xiaomin Zhang, Xiaorong Li
Summary: This study demonstrates that PSF inhibits HIF-1 alpha by recruiting Hakai, modulates mitochondrial bioenergetics and metabolism, and downregulates VEGF expression under hypoxic conditions, playing a crucial role in inhibiting pathological neovascularization associated with ophthalmopathy.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Clinical Neurology
Salomon Cohen-Cohen, Desmond A. Brown, Benjamin T. Himes, Lydia P. Wheeler, Michael W. Ruff, Brittny T. Major, Naykky M. Singh Ospina, John L. D. Atkinson, Fredric B. Meyer, Irina Bancos, William F. Young Jr, Jamie J. Van Gompel
Summary: In patients with MEN1, the prevalence of pituitary adenomas is higher in females than in males. Functional adenomas, especially prolactin-secreting adenomas, are more common than nonfunctional ones. Most asymptomatic nonfunctional adenomas can be safely followed, with only a small percentage progressing to require surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Fisheries
Angela Holder, Samantha M. Mirczuk, Robert C. Fowkes, Donald B. Palmer, Richard Aspinall, Brian Catchpole
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Rowena M. A. Packer, Alexander M. Davies, Holger A. Volk, Holly L. Puckett, Sarah L. Hobbs, Robert C. Fowkes
Article
Cell Biology
Samantha M. Mirczuk, Andrew J. Lessey, Alice R. Catterick, Rebecca M. Perrett, Christopher J. Scudder, Jordan E. Read, Victoria J. Lipscomb, Stijn J. Niessen, Andrew J. Childs, Craig A. McArdle, Imelda M. McGonnell, Robert C. Fowkes
Article
Orthopedics
F. ter Heegde, A. P. Luiz, S. Santana-Varela, R. Magnusdottir, M. Hopkinson, Y. Chang, B. Poulet, R. C. Fowkes, J. N. Wood, C. Chenu
OSTEOARTHRITIS AND CARTILAGE
(2020)
Article
Agriculture, Dairy & Animal Science
Lucy J. Jerram, Steven Van Winden, Robert C. Fowkes
Article
Veterinary Sciences
Christopher J. Scudder, Katarina Hazuchova, Ruth Gostelow, David B. Church, Yaiza Forcada, Robert C. Fowkes, Stijn J. M. Niessen
Summary: The study aimed to evaluate the effects of oral cabergoline treatment in cats with hypersomatotropism and diabetes mellitus. It was found that cabergoline did not significantly improve diabetic control, normalize IGF-1 concentration, or enhance patient quality of life.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2021)
Article
Veterinary Sciences
Rhiannon Strickland, Michael S. Tivers, Robert C. Fowkes, Victoria J. Lipscomb
Summary: Postattenuation neurological signs, including seizures, are common complications in cats treated for CPSS. Preoperative levetiracetam did not prevent the occurrence of PANS or seizures. The only risk factor identified for PANS was lower postoperative osmolality in cats with PANS at 24 hours.
VETERINARY SURGERY
(2021)
Article
Psychiatry
Gregory Milne, Chelsea Fujimoto, Theodor Bean, Harry J. Peters, Martin Hemmington, Charly Taylor, Robert C. Fowkes, Henny M. Martineau, Clare M. Hamilton, Martin Walker, Judy A. Mitchell, Elsa Leger, Simon L. Priestnall, Joanne P. Webster
FRONTIERS IN PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Samantha M. Mirczuk, Christopher J. Scudder, Jordan E. Read, Victoria J. Crossley, Jacob T. Regan, Karen M. Richardson, Bigboy Simbi, Craig A. McArdle, David B. Church, Joseph Fenn, Patrick J. Kenny, Holger A. Volk, Caroline P. Wheeler-Jones, Marta Korbonits, Stijn J. Niessen, Imelda M. McGonnell, Robert C. Fowkes
Summary: The expression and regulation of CNP/GC-B system in GH3 somatolactotrope cell line and pituitary tumours from feline hypersomatotropism patients were studied, revealing potential molecular mechanisms affecting growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Joe Fenn, Patrick J. Kenny, Christopher J. Scudder, Katarina Hazuchova, Ruth Gostelow, Robert C. Fowkes, Yaiza Forcada, David B. Church, Stijn J. M. Niessen
Summary: Transsphenoidal hypophysectomy is an effective and safe treatment for cats with HST and DM, improving diabetic control and achieving diabetic remission in the majority of cases. Long-term outcomes compare favorably to existing treatment options.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Cell Biology
Jacob T. Regan, Samantha M. Mirczuk, Christopher J. Scudder, Emily Stacey, Sabah Khan, Michael Worwood, Torinn Powles, J. Sebastian Dennis-Beron, Matthew Ginley-Hidinger, Imelda M. McGonnell, Holger A. Volk, Rhiannon Strickland, Michael S. Tivers, Charlotte Lawson, Victoria J. Lipscomb, Robert C. Fowkes
Summary: The study revealed that under conditions of hyperammonaemia, there was a significant inhibition of CNP-stimulated cGMP accumulation in both C6 glioma cells and GPNT cells, potentially affecting the functions of neurons, astrocytes, and endothelial cells.
Article
Endocrinology & Metabolism
Ken Ho, Maria Fleseriu, Ursula Kaiser, Roberto Salvatori, Thierry Brue, M. Beatriz Lopes, Pamela Kunz, Mark Molitch, Sally A. Camper, Monica Gadelha, Luis Syro, Edward Laws, Martin Reincke, Hiroshi Nishioka, Ashley Grossman, Ariel Barkan, Felipe Casanueva, John Wass, Adam Mamelak, Laurence Katznelson, Aart J. van der Lely, Sally Radovick, Martin Bidlingmaier, Margaret Boguszewski, Jens Bollerslev, Andrew R. Hoffman, Nelson Oyesiku, Gerald Raverot, Anat Ben-Shlomo, Rob Fowkes, Ilan Shimon, Hidenori Fukuoka, Alberto M. Pereira, Yona Greenman, Anthony P. Heaney, Mark Gurnell, Gudmundur Johannsson, Robert Y. Osamura, Michael Buchfelder, Maria Chiara Zatelli, Marta Korbonits, Philippe Chanson, Nienke Biermasz, David R. Clemmons, Niki Karavitaki, Marcello D. Bronstein, Peter Trainer, Shlomo Melmed
Summary: The debate over renaming pituitary neoplasms as PitNETs has sparked concerns among stakeholder groups. Experts recommend retaining the term adenoma and revisiting the topic as new evidence on pituitary neoplasm biology emerges.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Biology
Anthony E. Michael, Lisa M. Thurston, Robert C. Fowkes
Article
Endocrinology & Metabolism
Christopher J. Scudder, Samantha M. Mirczuk, Karen M. Richardson, Victoria J. Crossley, Jacob T. C. Regan, Ruth Gostelow, Yaiza Forcada, Katarina Hazuchova, Norelene Harrington, Imelda M. McGonnell, David B. Church, Patrick J. Kenny, Marta Korbonits, Robert C. Fowkes, Stijn J. M. Niessen
JOURNAL OF THE ENDOCRINE SOCIETY
(2019)
Article
Chemistry, Analytical
Amy Day, Zoe Jameson, Carolyn Hyde, Bigboy Simbi, Robert Fowkes, Charlotte Lawson
