Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Virology
Lu Zhang, Juan Liu, Erya Xiao, Qingzhen Han, Lin Wang
Summary: Viruses can create a unique cellular environment that facilitates replication and transmission. The SphK/S1P axis plays a crucial role in regulating cellular activities during viral infections. Depending on the type of virus, the SphK/S1P axis can have pro- or anti-viral activities through the host immune system or intracellular signaling pathways and cell proliferation.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Engineering, Biomedical
Jian Tang, Yang Liu, Mingxi Li, Xiao Wang, Anning Du, Ning Gu, Fang Yang
Summary: This study presents the design of sulfur hexafluoride (SF6)-loaded polylactic acid-co-glycolic acid (PLGA) nanobubbles (NBs) with a surface assembly of cyclodextrin (CD) and sphingosine-1-phosphate (S1P) (S1P@CD-PLGA NBs) for surveillance of vascular inflammation. The S1P@CD-PLGA NBs exhibit good stability, biosafety, and ultrasound imaging-enhancement effects, and demonstrate excellent in vivo targeting imaging capabilities.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Harsha Mahabaleshwar, P. Asharani, Tricia Yi Loo, Shze Yung Koh, Melissa R. Pitman, Samuel Kwok, Jiajia Ma, Bo Hu, Fang Lin, Xue Li Lok, Stuart M. Pitson, Timothy E. Saunders, Tom J. Carney
Summary: Mesenchymal cell immigration into growing fins and limb buds drives distal outgrowth, with tensile forces between these cells essential for fin and limb morphogenesis. Morphogens derived from the apical fin domain regulate cell polarity, migration, division, and adhesion of limb mesenchyme cells. The mutant stomp in zebrafish displays defects in fin morphogenesis, including blister formation and loss of orientation and adhesion of immigrating fin mesenchyme cells. The gene encoding Slit3, an axon guidance ligand, is found to be mutated in stomp. Slit ligands derived from immigrating mesenchyme act via Robo receptors at the apical ectodermal ridge (AER) to promote the release of sphingosine-1-phosphate (S1P), which then diffuses back to the mesenchyme to regulate their polarization, orientation, positioning, and adhesion to the interstitial matrix of the fin fold.
Article
Biochemistry & Molecular Biology
Rachel S. Knipe, Jillian J. Spinney, Elizabeth A. Abe, Clemens K. Probst, Alicia Franklin, Amanda Logue, Francesca Giacona, Matt Drummond, Jason Griffith, Patricia L. Brazee, Lida P. Hariri, Sydney B. Montesi, Katherine E. Black, Timothy Hla, Andrew Kuo, Andreane Cartier, Eric Engelbrecht, Christina Christoffersen, Barry S. Shea, Andrew M. Tager, Benjamin D. Medoff
Summary: Idiopathic pulmonary fibrosis is a chronic disease that causes respiratory failure. This study reveals the importance of vascular permeability in lung repair and fibrosis following injury, and the potential role of lipid mediator S1P in regulating this process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Caterina Bernacchioni, Veronica Ghini, Roberta Squecco, Eglantina Idrizaj, Rachele Garella, Elisa Puliti, Francesca Cencetti, Paola Bruni, Chiara Donati
Summary: Skeletal muscle atrophy is characterized by a decrease in muscle mass causing reduced agility, increased fatigability, and higher risk of bone fractures. Inflammatory cytokine TNF alpha is a strong inducer of skeletal muscle atrophy. The bioactive sphingolipid S1P plays an important role in skeletal muscle biology, exerting most of its actions through its specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chiara Donati, Francesca Cencetti, Caterina Bernacchioni, Valentina Vannuzzi, Paola Bruni
Summary: Fibrosis is a devastating multifaceted disease that can be treated by regulating the S1P signaling pathway and its cross-talk with other profibrotic mediators.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yashu Kuang, Xiaolin Li, Xiuxiang Liu, Lu Wei, Xiaoli Chen, Jie Liu, Tao Zhuang, Jingjiang Pi, Yanfang Wang, Chenying Zhu, Xin Gong, Hao Hu, Zuoren Yu, Jiming Li, Ping Yu, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Lin Zhang
Summary: Loss of endothelial S1pr1 exacerbates post-MI cardiac remodelling and worsens cardiac dysfunction by reducing reparative macrophage accumulation. Activation of S1pr1 enhances Ly6c(low) macrophage proliferation and ameliorates cardiac remodelling after MI through the ERK/CSF1 pathway.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Olivia Garnier, Isabelle Vilgrain
Summary: The endothelial cells in established blood vessels are quiescent but play a crucial role in controlling the permeability of the blood vessel interior. Adherens junctions, which are intercellular contacts, are important for the organization and maintenance of the endothelial cell monolayer. The dysfunction of adherens junctions and the role of sphingosine-1-phosphate signaling in vascular disease are still open questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Gillis Greiwe, Eileen Moritz, Katharina Amschler, Annika Poppe, Harun Sarwari, Axel Nierhaus, Stefan Kluge, Hermann Reichenspurner, Christian Zoellner, Edzard Schwedhelm, Guenter Daum, Bjoern Tampe, Martin Sebastian Winkler
Summary: This study found that major cardiac surgery disrupts serum S1P levels, with post-surgery low S1P levels potentially serving as a new marker for evaluating the severity of surgery-induced inflammation. Patients whose S1P levels did not recover to preoperative levels had longer ICU stays and more severe postoperative inflammation. Additionally, the study suggests that high-dose heparin during surgery may have an inhibitory effect on circulating S1P levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Review
Biochemistry & Molecular Biology
Girish Jayant, Stephen Kuperberg, Kaumudi Somnay, Raj Wadgaonkar
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by scarring and fibrotic transformation of the lung, leading to respiratory function loss and often death. Increased vascular permeability has been identified as a contributing factor to fibrogenesis. Sphingolipids, particularly the sphingosine-1-phosphate (S1P) axis, play a critical role in cell signaling pathways affecting vascular endothelial integrity. This review focuses on the role of sphingolipids in IPF pathogenesis and explores the potential of S1P modulators as therapeutic targets for IPF.
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Biochemistry & Molecular Biology
Ilari Pulli, Tomas Blom, Christoffer Lof, Melissa Magnusson, Alessandro Rimessi, Paolo Pinton, Kid Tornquist
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Endocrinology & Metabolism
H. Undeutsch, C. Loef, P. Pakarinen, M. Poutanen, J. Kero
Article
Biochemistry & Molecular Biology
Muhammad Yasir Asghar, Melissa Magnusson, Kati Kemppainen, Pramod Sukumaran, Christoffer Lof, Ilari Pulli, Veronica Kalhori, Kid Tornquist
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Endocrinology & Metabolism
Christoffer Lof, Konrad Patyra, Teemu Kuulasmaa, Jagadish Vangipurapu, Henriette Undeutsch, Holger Jaeschke, Tuulia Pajunen, Andreina Kero, Heiko Krude, Heike Biebermann, Gunnar Kleinau, Peter Kuhnen, Krista Rantakari, Paivi Miettinen, Turkka Kirjavainen, Juha-Pekka Pursiheimo, Taina Mustila, Jarmo Jaaskelainen, Marja Ojaniemi, Jorma Toppari, Jaakko Ignatius, Markku Laakso, Jukka Kero
Article
Endocrinology & Metabolism
C. Lof, K. Patyra, A. Kero, J. Kero
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
Konrad Patyra, Holger Jaeschke, Christoffer Lof, Meeri Jannari, Suvi T. Ruohonen, Henriette Undeutsch, Moosa Khalil, Andreina Kero, Matti Poutanen, Jorma Toppari, Min Chen, Lee S. Weinstein, Ralf Paschke, Jukka Kero
Article
Developmental Biology
Henriette Undeutsch, Christoffer Lof, Stefan Offermanns, Jukka Kero
Article
Biochemistry & Molecular Biology
Pramod Sukumaran, Christoffer Lof, Kati Kemppainen, Pasi Kankaanpaa, Ilari Pulli, Johnny Nasman, Tero Viitanen, Kid Tornquist
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Cell Biology
Tero M. Viitanen, Pramod Sukumaran, Christoffer Lof, Kid Tornquist
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
Article
Cell Biology
Pramod Sukumaran, Christoffer Lof, Ilari Pulli, Kati Kemppainen, Tero Viitanen, Kid Tornquist
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2013)
Article
Endocrinology & Metabolism
Christoffer Lof, Pramod Sukumaran, Tero Viitanen, Minna Vainio, Kati Kemppainen, Ilari Pulli, Johnny Nasman, Jyrki P. Kukkonen, Kid Tornquist
MOLECULAR ENDOCRINOLOGY
(2012)
Review
Physiology
Kid Tornquist, Pramod Sukumaran, Kati Kemppainen, Christoffer Lof, Tero Viitanen
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2014)
Article
Endocrinology & Metabolism
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Lof, Markus Eszlinger, Moosa Khalil, Meeri Jannari, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, Jukka Kero
Article
Biochemistry & Molecular Biology
I Pulli, C. Lof, T. Blom, M. Y. Asghar, T. Lassila, N. Back, K-L Lin, J. H. Nystrom, K. Kemppainen, D. M. Toivola, E. Dufour, A. Sanz, H. M. Cooper, J. B. Parys, K. Tornquist
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Hakan Cangul, Xiao-Hui Liao, Erik Schoenmakers, Jukka Kero, Sharon Barone, Panudda Srichomkwun, Hideyuki Iwayama, Eva G. Serra, Halil Saglam, Erdal Eren, Omer Tarim, Adeline K. Nicholas, Ilona Zvetkova, Carl A. Anderson, Fiona E. Karet Frankl, Kristien Boelaert, Marja Ojaniemi, Jarmo Jaaskelainen, Konrad Patyra, Christoffer Lof, E. Dillwyn Williams, Ukk Consortium, Manoocher Soleimani, Timothy Barrett, Eamonn R. Maher, V. Krishna Chatterjee, Samuel Refetoff, Nadia Schoenmakers