Article
Endocrinology & Metabolism
Pablo Remon-Ruiz, Eva Venegas-Moreno, Elena Dios-Fuentes, Juan Manuel Canelo Moreno, Ignacio Fernandez Pena, Miriam Alonso Garcia, Miguel Angel Japon-Rodriguez, Florinda Roldan, Elena Fajardo, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, David Cano, Alfonso Soto-Moreno
Summary: Imaging and pathology evaluation may not accurately predict the aggressiveness of pituitary tumors, but histological examination can provide useful information. Our case report highlights the importance of suspicion for malignancy in pituitary tumors with aggressive features and the need for multidisciplinary team follow-up to manage potential metastases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Atsushi Ishida, Hiroki Shichi, Hidenori Fukuoka, Hideki Shiramizu, Naoko Inoshita, Shozo Yamada
Summary: The authors propose a novel treatment option for rare and aggressive somatotroph pituitary tumors, and demonstrate the effectiveness of combination therapy with CAPTEM based on patient-derived 3D spheroid ex vivo assay results.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Peng Du, Xuefan Wu, Kun Lv, Ji Xiong, Daoying Geng
Summary: Pituitary carcinoma is a rare and difficult-to-diagnose disease, with conventional treatments showing limited effectiveness. This article reports a case of sparsely granulated somatotroph carcinoma with a favorable treatment response to temozolomide combined with radiation therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Article
Endocrinology & Metabolism
Cristina Lamas, Rosa Camara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Perez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio Garcia-Centeno, Alfonso Soto
Summary: In this retrospective study, temozolomide was found to be an effective medical treatment for aggressive pituitary neuroendocrine tumors and pituitary carcinomas, but may sometimes lead to tumor progression. Co-administration with radiotherapy may increase progression-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ann McCormack
Summary: The use of temozolomide in the treatment of aggressive pituitary tumours and pituitary carcinomas has significantly improved patient survival. There is increasing interest in exploring its early use in the treatment algorithm. The overall response rate is around 40% with stable disease in 25%, demonstrating its clinical effectiveness. Combination radiotherapy and temozolomide may be more effective in patients who have not reached maximal radiation thresholds.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Oriol Mirallas, Francesca Filippi-Arriaga, Irene Hernandez Hernandez, Anton Aubanell, Anas Chaachou, Alejandro Garcia-Alvarez, Jorge Hernando, Elena Martinez-Saez, Betina Biagetti, Jaume Capdevila
Summary: Nelson's syndrome is a severe side effect that can occur after total bilateral adrenalectomy in patients with Cushing's disease, presenting with symptoms of pituitary tumor enlargement. Chemotherapy with capecitabine and temozolomide is sometimes considered as an off-label treatment option, but its effectiveness is controversial due to adverse events and unpredictable results.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Odelia Cooper, Vivien Bonert, Ning-Ai Liu, Adam N. Mamelak
Summary: Management of aggressive pituitary adenomas is challenging due to lack of rigorous evidence supporting treatment approaches; recent guidelines emphasize maximizing standard therapies and using temozolomide and radiation therapy for recurrence; multidisciplinary, individualized approach is crucial, but timing and rationale for surgery, radiation therapy, medication need to be discussed within evidence-based guidelines for effective management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Mei Luo, Yiheng Tan, Wenli Chen, Bin Hu, Zongming Wang, Diming Zhu, Haosen Jiao, Chengbin Duan, Yonghong Zhu, Haijun Wang
Summary: Temozolomide demonstrates significant radiological and biochemical response rates in patients with APT and PC, leading to prolonged PFS and OS. Low/intermediate MGMT expression and functional subtype may serve as important predictors of TMZ efficacy. Combination therapy of radiotherapy with TMZ shows improved outcomes in clinical settings.
FRONTIERS IN NEUROLOGY
(2021)
Review
Surgery
Xiaohai Liu, Congxin Dai, Ming Feng, Mingchu Li, Ge Chen, Renzhi Wang
Summary: Refractory pituitary adenomas, a term proposed by one of the largest pituitary centers in China, are defined as adenomas with a Ki-67 labeling index >= 3%, faster growth rate than normal PA, infiltration of surrounding tissues, early postoperative recurrence/regrowth, and continued growth/secreting hormones despite attempts to control it. Treatment of refractory PA remains a significant challenge that requires a multidisciplinary approach.
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Helene Lasolle, Alexandre Vasiljevic, Emmanuel Jouanneau, Mirela Diana Ilie, Gerald Raverot
Summary: Pituitary tumors are usually benign, but aggressive pituitary tumors and carcinomas are rare and challenging to treat, with high mortality rates. Most of these are corticotroph tumors, which have special prognoses. Current clinical, pathological, and molecular prognostic markers are limited, making early management difficult. Temozolomide is the first-line treatment, with immune checkpoint inhibitors as alternative options for temozolomide treatment failure.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu-Fang Wu, Hui Yi Ng, Divya Namboodiri, David Lewis, Andrew Davidson, Bernard Champion, Veronica Preda
Summary: This case report presents a successful conservative approach to thyrotropinoma discovered during pregnancy. It emphasizes the importance of carefully considering the timing of intervention with consideration of risks to both the mother and fetus.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
Article
Endocrinology & Metabolism
Huy Gia Vuong, Ian F. Dunn
Summary: Sparsely granulated somatotroph adenoma/tumor (SGST) and densely granulated somatotroph adenoma/tumor (DGST) are different in demographics, clinicopathological features, and molecular characteristics. SGST is associated with adverse treatment outcomes and poor response to medical therapy.
Review
Clinical Neurology
Sam Ng, Mahmoud Messerer, Julien Engelhardt, Michael Bruneau, Jan Frederick Cornelius, Luigi Maria Cavallo, Giulia Cossu, Sebastien Froelich, Torstein R. Meling, Dimitrios Paraskevopoulos, Henry W. S. Schroeder, Marcos Tatagiba, Idoya Zazpe, Moncef Berhouma, Roy T. Daniel, Edward R. Laws, Engelbert Knosp, Michael Buchfelder, Henri Dufour, Stephane Gaillard, Timothee Jacquesson, Emmanuel Jouanneau
Summary: Aggressive pituitary neuroendocrine tumors (APT) account for 10% of pituitary tumors and their management is rapidly evolving. The new term Pituitary neuroendocrine tumors (PitNet) reflects a shift towards a neuro-oncological-like approach. Treatment recommendations include surgery, temozolomide, local radiotherapy, and novel therapies such as VEGF-targeted therapies and immunotherapies.
ACTA NEUROCHIRURGICA
(2021)
Article
Endocrinology & Metabolism
Graziella Mendonca Monteiro de Barros, Miguel Madeira, Leonardo Vieira Neto, Francisco de Paula Paranhos Neto, Laura Maria Carvalho Mendonca, Inaya Correa Barbosa Lima, Rossana Corbo, Maria Lucia Fleiuss Farias
JOURNAL OF BONE AND MINERAL METABOLISM
(2016)
Article
Endocrinology & Metabolism
Mariana Arruda, Maria Caroline Alves Coelho, Aline Barbosa Moraes, Francisco de Paula Paranhos-Neto, Miguel Madeira, Maria Lucia Fleiuss Farias, Leonardo Vieira Neto
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Article
Computer Science, Interdisciplinary Applications
E. O. Rodrigues, F. F. C. Morais, N. A. O. S. Morais, L. S. Conci, L. V. Neto, A. Conci
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2016)
Article
Endocrinology & Metabolism
Maria Caroline Alves Coelho, Nathalie Anne de Oliveira e Silva de Morais, Andrea Cristiani Beuren, Cristiane Bertolino Lopes, Camila Vicente Santos, Joyce Cantoni, Leonardo Vieira Neto, Mauricio Barbosa Lima
ENDOCRINE PRACTICE
(2016)
Article
Surgery
Eduardo Madeira, Miguel Madeira, Erika Paniago Guedes, Thiago Thomaz Mafort, Leonardo Vieira Neto, Rodrigo de Oliveira Moreira, Paulo Roberto Alves de Pinho, Agnaldo Jose Lopes, Maria Lucia Fleiuss Farias
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2016)
Article
Peripheral Vascular Disease
Mariana Arruda, Emanuela Mello Ribeiro Cavalari, Marcela Pessoa de Paula, Felipe Fernandes Cordeiro de Morais, Guilherme Furtado Bilro, Maria Caroline Alves Coelho, Nathalie Anne de Oliveira e Silva de Morai, Diana Choeri, Aline Moraes, Leonardo Vieira Neto
JOURNAL OF HUMAN HYPERTENSION
(2017)
Article
Endocrinology & Metabolism
A. B. Moraes, E. M. R. Cavalari, M. P. de Paula, M. Arruda, D. S. C. Curi, R. A. Leitao, L. M. C. de Mendonca, M. L. F. Farias, M. Madeira, L. Vieira Neto
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2019)
Review
Endocrinology & Metabolism
E. P. Brabo, A. B. Moraes, L. V. Neto
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Biochemical Research Methods
Julio M. X. Amaral, Monica C. Padilha, Silvana Chagas, Julien S. Baker, Carrie Mullen, Leonardo Vieira Neto, Francisco R. Aquino Neto, Marcelo S. Cruz
Summary: This study details the treatment of a man who attempted suicide after experiencing symptoms of anxiety and aggressiveness associated with the use of AAS. Regular use of fluoxetine was effective in preventing anxiety, depression, aggressiveness, and suicide ideation, even in the presence of AAS. Urinary concentration of androgens, AAS metabolites, and fluoxetine were monitored through urine samples analysis at the Brazilian Laboratory of Doping Control.
DRUG TESTING AND ANALYSIS
(2021)
Article
Endocrinology & Metabolism
M. O. Rodrigues, A. B. Moraes, M. P. de Paula, V. A. Pereira, A. T. T. Leao, L. Vieira Neto
Summary: This study found that patients with AI have a higher frequency and severity of periodontitis compared to controls. Patients with NFAI and possible ACS had worse periodontal conditions, with periodontitis rates of 72.7% and 84.6% respectively, indicating a more severe condition in possible ACS compared to NFAI and controls.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Frederico Arthur Pereira Nunes, Maria Lucia Fleiuss de Farias, Felipe Peres Oliveira, Leonardo Vieira Neto, Luis Felipe Cardoso Lima, Francisco de Paula Paranhos Neto, Laura Maria Carvalho de Mendonca, Miguel Madeira
Summary: The study evaluated changes in bone density and structure in postmenopausal women with breast cancer using aromatase inhibitor (AI). Results showed that patients using AI exhibited significant differences in bone density and microstructure, with a higher risk of fractures.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Biochemical Research Methods
Julio X. Amaral, Andrea C. Deslandes, Monica C. Padilha, Leonardo Vieira Neto, Luiz E. Osorio, Francisco Radler Aquino Neto, Marcelo S. Cruz
Summary: The use of androgenic-anabolic steroids (AAS) can lead to psychiatric symptoms such as insomnia, anxiety, and increased aggressiveness. This study on bodybuilders found that the majority of participants experienced symptoms of agitation, insomnia, increased aggressiveness, or depression. There was no significant difference in psychiatric symptoms between males and females, and no direct association between symptoms and drug dosage.
DRUG TESTING AND ANALYSIS
(2022)
Article
Endocrinology & Metabolism
Felipe P. Oliveira, Luis F. C. Lima, Francisco de Paula Paranhos Neto, Laura M. C. de Mendonca, Annie Schtscherbyna, Luiz A. A. de Lima, Branca A. Fonseca, Miguel Madeira, Ronir R. Luiz, Leonardo Neto, Maria L. F. Farias, Elizabeth S. Machado
Summary: MLWH have alterations in bone volumetric density and microstructure compared to controls, regardless of aBMD, which are associated with lower E-2 and BMI. Lower BMI and fat mass in MLWH are positively associated with total vBMD, cortical bone area, and thickness. E-2 and E-2/T ratios are lower in MLWH than in controls and significantly correlated with several cortical and trabecular bone parameters.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Joao Felipe Dickson Rebelo, Julia Magarao Costa, Fernanda Damasceno Junqueira, Adelmo de Oliveira Fonseca, Ana Beatriz Alcantara Berenger Samarcos de Almeida, Aline Barbosa Moraes, Leonardo Vieira Neto
Summary: Although there is limited data, this study aimed to compare cardiometabolic clinic parameters among patients with autonomous cortisol secretion (ACS) and nonfunctioning adrenal incidentalomas (NFAI), as well as controls. The results showed that both ACS and NFAI patients had a higher frequency of cardiovascular risk factors compared to controls.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Natalia Treistman, Aline Barbosa Moraes, Stephanie Cozzolino, Patricia de Fatima dos Santos Teixeira, Leonardo Vieira Neto
CASE REPORTS IN MEDICINE
(2019)