Article
Endocrinology & Metabolism
Viral N. Shah, Halis K. Akturk, Hal Joseph, Nicole Schneider, Janet K. Snell-Bergeon
Summary: The study evaluated two methods of transition from an insulin pump to multiple daily injections using long-acting insulin degludec (IDeg), showing that patients who underwent overlap transition method achieved a significant improvement in time-in-range during the first week without increasing hypoglycemia rates.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xu Wang, Xue Zhao, Danrong Chen, Mingzhi Zhang, Wei Gu
Summary: A comparison of treatment regimens for T1D in children using a combination of meta-analysis and prospective cohort study revealed that CSII may be associated with better glycemic control and growth development without increasing the risk of long-term complications or delaying puberty.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria G. Thomas, Parizad Avari, Ian F. Godsland, Aaron M. Lett, Monika Reddy, Nick Oliver
Summary: This systematic review and meta-analysis found that compared to MDI, CSII can significantly reduce glycated haemoglobin levels, and compared to SMBG, CGM can also significantly reduce glycated haemoglobin levels. CGM is more effective in reducing severe hypoglycemia compared to SMBG, while CSII does not show a significant change in severe hypoglycemia compared to MDI. Additionally, CSII is associated with a higher risk of diabetic ketoacidosis. Both CSII and CGM are effective interventions, but CGM may have a greater impact on reducing glycaemic variability and severe hypoglycaemia in adults with type 1 diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Engineering, Biomedical
Marzia Cescon, Sunil Deshpande, Revital Nimri, Francis J. Doyle III, Eyal Dassau
Summary: This study designed iterative algorithms for delivering long-acting and rapid-acting insulin for T1D patients, showing significant improvements in blood glucose control with iterative learning. The strategy demonstrated statistically significant improvements in time in range when meal CHO was normally distributed. Decision support systems and automated therapy advisors are expected to improve glycemic outcomes and reduce burdens on patients receiving MDI therapy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Computer Science, Interdisciplinary Applications
Ernesto Estremera, Aleix Beneyto, Alvis Cabrera, Ivan Contreras, Josep Vehi
Summary: This study proposes an intermittent closed-loop control system for multiple daily injection therapy in people with type 1 diabetes. The control algorithm is based on model predictive control and incorporates correction insulin boluses and rescue carbohydrates to optimize glycaemic control. In-silico evaluations demonstrate the superiority of the proposed algorithm over conventional open-loop therapy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Engineering, Biomedical
Anas El Fathi, Robert E. Kearney, Emilie Palisaitis, Benoit Boulet, Ahmad Haidar
Summary: The study introduces a model-based iterative algorithm to optimize insulin doses for type 1 diabetes patients using multiple daily injections, showing potential in improving glycemic control and enhancing quality of life.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Mark A. Sperling, Lori M. Laffel
Summary: A 12.5-year-old pubertal girl is referred to a tertiary medical center for management of new-onset diabetes mellitus. The initial evaluation reveals glucosuria but no ketonuria. She has no family history of type 1 diabetes mellitus and her physical examination is normal except for Tanner stage 3 breast and pubic hair development.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Obstetrics & Gynecology
Karin Kjolhede, Kerstin Berntorp, Karl Kristensen, Anastasia Katsarou, Nael Shaat, Nana Wiberg, Filip K. Knop, Lars Kristensen, Annika Dotevall, Anders Elfvin, Ulrika Sandgren, Verena Sengpiel, Linda Englund-Ogge
Summary: Analysis of CGM data in pregnant women with type 1 diabetes showed no significant differences in glycemic control and pregnancy outcomes between those using MDI and pump therapy. However, glucose levels remained suboptimal throughout pregnancy regardless of insulin administration mode.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Michael S. S. Hughes, Julia L. L. Douvas, Madison Layfield-Bryan, Luis E. E. Blanco, John Clark Gray, Grzegorz Zapotoczny, Juan Espinoza, John H. H. Wilcox, Rayhan A. A. Lal
Summary: Insulin infusion site (IIS) failures are common in individuals with diabetes on insulin pump therapy and often go undetected until hyperglycemia occurs. These failures are associated with negative perceptions and may be prevented or detected sooner through additional measures.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Laura J. Reid, Fraser W. Gibb, Helen Colhoun, Sarah H. Wild, Mark W. J. Strachan, Karen Madill, Baljean Dhillon, Shareen Forbes
Summary: This study compared the progression of diabetic retinopathy in patients with type 1 diabetes who received CSII therapy versus MDI therapy. The results showed that CSII therapy was associated with reduced progression of diabetic retinopathy compared to continued MDI therapy, especially for patients with high baseline HbA(1c). The progression of retinopathy over 3 years was not affected by changes in HbA(1c).
Article
Endocrinology & Metabolism
Tugba Barlas, Mehmet Muhittin Yalcin, Meric Coskun, Dilek Demirel, Alev Eroglu Altinova, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Ilhan Yetkin, Mujde Akturk
Summary: The objective of this study was to determine lipohypertrophy (LH) in patients with type 1 diabetes mellitus on multiple daily insulin injections (MDII) or continuous subcutaneous insulin infusion (CSII) and to identify factors associated with LH development and severity. LH localizations were detected using palpation and ultrasonography (USG), with USG showing a significantly higher detection rate in the whole group. LH was more severe in the MDII group than in the CSII group, and its severity was positively correlated with HbA1C and insulin dose. MDII as an insulin administration method, incorrect rotation technique, and a history of ketosis were found to be the most related factors with LH severity.
ENDOCRINE PRACTICE
(2023)
Article
Health Care Sciences & Services
Dana E. Stallings, Karen J. Higgins
Summary: This study aimed to measure the change in HgbA1c in patients with type 2 diabetes (T2D) after switching therapy from multiple daily injections (MDI) to continuous subcutaneous insulin infusion through insulin pump therapy (IPT). The results showed a statistically significant reduction in mean HgbA1c levels from 9.6% to 7.6% after using IPT.
JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
(2023)
Article
Endocrinology & Metabolism
Louisa van den Boom, Karel Kostev
Summary: The study found a decrease in the proportion of patients using insulin pump therapy with age, and insulin aspart was the most commonly used short-acting insulin. The daily dose of insulin pump therapy was 10 units lower than multiple daily injection therapy.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Shunsuke Kobayashi, Mototsugu Nagao, Izumi Fukuda, Shinichi Oikawa, Hitoshi Sugihara
Summary: Multiple daily insulin injections can ameliorate the QT interval by lowering blood glucose levels in patients with T2D, with Delta FPG found to be positively correlated with Delta QTc. The study emphasizes the importance of glycemic control in preventing sudden cardiac death in patients with diabetes.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Health Care Sciences & Services
Lilian Tzivian, Jelizaveta Sokolovska, Anna E. Grike, Agate Kalcenaua, Abraham Seidmann, Arriel Benis, Martins Mednis, Ieva Danovska, Ugis Berzins, Arnolds Bogdanovs, Emil Syundyukov
Summary: This study explored the differences and factors related to the quality of life (QoL) of type 1 diabetes patients using insulin pumps versus injections in Latvia. The study found that insulin pump users were younger, had higher incomes, and reported higher diabetes-related expenses. Qualitative data further supported the quantitative analysis results. The reimbursement policies should be considered to allow patients to choose the more convenient treatment method.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)