Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis

Results from studies on the association of PTPN22 C1858T polymorphism with AITD risk are conflicting, we thereby perform this meta-analysis to derive a more precise effect on this possible association. Two investigators independently searched the PubMed, Embase, Wanfang and CNKI (China National Knowledge Infrastructure) databases. A total of 11 studies with 3764 AITDs cases and 3328 controls were finally identified. Statistically significant association was observed between PTPN22 C1858T polymorphism and AITD risk based on all studies (TT vs. CC, OR=2.18, 95%CI=1.31 similar to 3.62; TC vs. CC, OR=1.50, 95%CI=1.29 similar to 1.73; TT/TC vs. CC, OR=1.41, 95%CI=1.12 similar to 1.78; TT vs. TC/CC, OR=2.00, 95%CI=1.21 similar to 3.33). The results of subgroup analysis showed that: (1) regarding ethnic diversity, the variant genotypes TT/TC of C1858T were associated with a significantly increased AITD risk in Caucasians (TT/TC vs. CC, OR=1.41, 95%CI=1.09 similar to 1.83) (2) regarding different countries, the statistically significantly association was observed in UK (TC vs. CC, OR=1.64, 95%CI=1.36 similar to 1.98; TT/TC vs. CC, OR=1.65, 95%CI=1.37 similar to 1.98) and other countries (including Tunisia, Russia, Poland, Japan) (TT vs. CC, OR=3.65, 95%CI=1.43 similar to 9.33; TT vs. TC/CC, OR=3.41, 95%CI=1.34 similar to 8.65). (3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of CI858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36 similar to 4.05; TC vs. CC, OR=1.46, 95%CI=1.12 similar to 1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33 similar to 1.80; TT vs. TC/CC, OR=2.16, 95%I=1.25 similar to 3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT). No publication bias was observed. Our results demonstrated that PTPN22 C1858T polymorphism was associated with AITD risk, especially in Caucasians.