期刊
ENDOCRINE JOURNAL
卷 57, 期 9, 页码 793-802出版社
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K10E-020
关键词
Plasma adiponectin; Major adverse cardiovascular events (MACE); Coronary artery disease; Type 2 diabetes mellitus
资金
- National Science Council [NSC 94-2314-B-475-001]
- E-Da Hospital of the Republic of China, Taiwan [EDAHI-98007]
Elevated levels of circulating adiponectin (ADPN), an anti- inflammatory and anti-oxidative peptide, are associated with unfavorable cardiovascular outcomes in patients with cardiovascular diseases. The aim of this study was to investigate whether plasma ADPN levels could help predict major adverse cardiovascular events (MACE) in patients with documented coronary artery disease (CAD). We prospectively enrolled 193 CAD patients, who underwent percutaneous coronary intervention (PCI), and/or stenting and coronary artery bypass graft (CABG) surgery. ELISA was used to measure plasma ADPN concentrations. MACE myocardial infarction, PCI, CABG, stroke, carotid revascularization, and death was evaluated during a follow-up period of median 15.3 months (range 5-21 months). Cox regression analysis revealed that diabetes status, waist circumference, and plasma ADPN levels were significantly associated with MACE occurrence. On stratification according to diabetes status, plasma ADPN levels helped predict MACE only in patients with type 2 diabetes mellitus (T2DM). Kaplan-Meier analysis revealed higher MACE rates in diabetic patients with high-plasma ADPN levels than in those with low-plasma ADPN levels. High ADPN plasma concentrations can independently be associated with MACE in CAD with T2DM but not in those without diabetes. This indicates that plasma ADPN may have potential roles in high risk T2DM patients with ischemic heart disease.
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