Article
Environmental Sciences
Francesca Coperchini, Alessia Greco, Laura Croce, Marco Denegri, Flavia Magri, Mario Rotondi, Luca Chiovato
Summary: This study investigated the adverse effects of the pesticide Glyphosate on thyroid cells in vitro. The results showed that Glyphosate reduced cell viability and proliferation, and increased the production of reactive oxygen species. Additionally, Glyphosate increased the mRNA levels of thyroid-related genes. This study supports the detrimental effects of Glyphosate on cultured thyroid cells.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Jin-Ah Ryuk, Hiroe Go, Byoung-Seob Ko
Summary: Aloe vera, a traditional herbal medicine, has the ability to regulate the production of thyroid hormones and maintain endocrine homeostasis. It acts through the TPO and PKA pathways to regulate thyroxine release.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Gaiping Wen, Klaus Eder, Robert Ringseis
Summary: The study showed that resveratrol alleviates the inhibitory effect of tunicamycin-induced ER stress on key gene expression in thyroid cells. Co-treatment can mitigate the impact caused by exposure to tunicamycin alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hao Fu, Jing Wu, Jingxiong Huang, Long Sun, Hua Wu, Wei Guo, Sihuang Qiu, Haojun Chen
Summary: This study evaluated the clinical utility of Ga-68-FAPI PET/CT for detecting metastatic differentiated thyroid cancer (DTC) and compared it with F-18-FDG PET/CT. The results showed that Ga-68-FAPI PET/CT had a higher sensitivity than F-18-FDG PET/CT for depicting metastatic DTC, especially in lymph nodes and pulmonary metastases.
Article
Genetics & Heredity
Samantha Peiling Yang, Lian Chye Winston Koh, Kiat Whye Kong, Rajeev Parameswaran, Kelvin Siu Hoong Loke, Kee Yuan Ngiam, Wee Boon Tan, Thomas Loh, David Chee Eng Ng, Boon Cher Goh, Joanne Ngeow, E. Shyong Tai
Summary: This study identified potential biomarkers in thyroid-specific cfRNA that could track residual thyroid mass post-treatment, with TPO cfRNA showing promise as an early indicator of remnant thyroid tissue volume. The quantifiable decrease in cfRNA transcripts (TPO, GFRA2, IVD, TG) post-treatment suggests their utility in determining residual thyroid tissue. The cfRNA could be optimized for quantification of thyroid volume to guide RAI doses and detection of thyroid cancer recurrence.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Mirian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola
Summary: The study reports the generation of transplantable thyroid organoids derived from human embryonic stem cells, which can restore thyroid hormone levels in athyreotic mice. Thyroid hormones are essential for the normal functioning and growth of tissues, and hypothyroidism is a common disorder that is difficult to treat effectively. This research provides proof of concept for future therapeutic development.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Nicola Viola, Laura Agate, Sonia Caprio, Loredana Lorusso, Alessandro Brancatella, Debora Ricci, Daniele Sgro, Clara Ugolini, Paolo Piaggi, Paolo Vitti, Rossella Elisei, Ferruccio Santini, Francesco Latrofa
Summary: The relevance of thyroid autoimmunity to the prognosis of papillary thyroid carcinoma is still uncertain. This study found that thyroid autoimmunity does not affect the prognosis of papillary thyroid carcinoma, but detectable thyroglobulin antibodies (TgAbs) can prolong the time to remission. A decreasing TgAb trend seems to be an appropriate criterion for establishing remission of papillary thyroid carcinoma.
ENDOCRINE-RELATED CANCER
(2023)
Review
Medical Laboratory Technology
Maria Luisa Garo, Alfredo Campenni, Petra Petranovic-Ovcaricek, Federica D'Aurizio, Luca Giovanella
Summary: Laboratory medicine has greatly improved over the past three decades, thanks to technological advancements and new materials. The development of rapid, accurate, and sensitive tests has addressed clinicians' demands for powerful and minimally invasive tests, bringing us closer to personalized medicine. However, there are challenges in the harmonization of Tg and CT assays and the interchangeability of laboratory results and cutoff values. New diagnostic and monitoring approaches have shown effectiveness, but close collaboration between clinicians and laboratory specialists is still necessary for appropriate clinical interpretation criteria.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Carole Ann Spencer
Summary: This review highlights the development of laboratory thyroid tests over the past seven decades, from manual isotopically labeled iodine procedures to automated nonisotopic tests. The introduction of radioimmunoassay techniques and monoclonal antibody technology has played a crucial role in the evolution of thyroid testing. Despite improvements, current tests still face limitations in terms of numerical differences and interferences from reagents and autoantibodies.
Article
Oncology
Santa D'angeli, Nunzia Cinzia Paladino, Christelle Fargette, Cendrine Archange, Wassim Essamet, Zeinab Hamidou, Fausto Palazzo, Karine Baumstarck, David Taieb
Summary: The use of thyroglobulin concentration in washout fluid of fine-needle aspiration (FNA-Tg) is recommended for diagnosing metastatic lymph nodes (LNs) in papillary thyroid cancer (PTC). This study aimed to determine the diagnostic performance of FNA-Tg in detecting metastatic PTC in the presence of an intact thyroid gland. The results indicate that the optimal cutoff value for FNA-Tg in diagnosing malignant LNs is 60 ng/ml, with a sensitivity of 75% and specificity of 87.5%. Therefore, using lower thresholds may result in false positive results and unnecessary surgery.
Article
Endocrinology & Metabolism
Anwar A. Jammah, Afshan Masood, Layan A. Akkielah, Shaimaa Alhaddad, Maath A. Alhaddad, Mariam Alharbi, Abdullah Alguwaihes, Saad Alzahrani
Summary: After total thyroidectomy and RAI ablation, undetectable levels of serum thyroglobulin indicate excellent responders with very low recurrence risk. Stimulated thyroglobulin is beneficial for re-classifying patients and estimating their risk for incomplete responses over a 7-year follow-up period in DTC patients with nsTg levels of 0.1-2 ng/ml.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Julia E. Noel, Priyanka Thatipamala, Kay S. Hung, Julie Chen, Run-Zhang Shi, Lisa A. Orloff
Summary: This study aimed to evaluate the significance of antithyroglobulin and antithyroid peroxidase antibody levels in patients with well-differentiated thyroid cancer. Results showed that elevated TgAb levels were associated with nodal metastases and ENE, while elevated TPOAb levels were correlated with lower T and N stages.
ENDOCRINE PRACTICE
(2021)
Article
Medical Laboratory Technology
Sara Deza, Julia Maroto, Olaia Tellechea, Natalia Orbegozo, Juana Merino, Juan C. Galofre, Estibaliz Alegre, Alvaro Gonzalez
Summary: This study evaluated the response to treatment in patients with differentiated thyroid cancer and considered the interference of anti-thyroglobulin antibodies. Results showed discrepancies between two different thyroglobulin quantification methods, but the clinical impact on patient management was minimal.
CLINICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Nils Marechal, Banyuhay P. Serrano, Xinyan Zhang, Charles J. Weitz
Summary: Thyroid hormones play vital roles in metabolism, development, and growth, but the process of their formation is still poorly understood. By analyzing the cryo-EM structure of native bovine thyroglobulin, scientists have identified local structural rearrangements during the formation of nascent thyroid hormones, providing insights into the mechanisms underlying hormone formation and stabilization.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Yushen Gu, Hongrong Xu, Yanling Yang, Yan Xiu, Pengcheng Hu, Min Liu, Xiangqing Wang, Jun Song, Yan Di, Jian Wang, Xiaoxia Zhang, Tao Xu, Xuening Li, Hongcheng Shi
Summary: SNA001 is a novel recombinant human thyroid stimulating hormone used for monitoring and ablation of thyroid carcinoma without causing hypothyroidism. Research conducted on DTC patients demonstrates the potential safety and effectiveness of SNA001 in promoting iodine-131 uptake and Tg secretion.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Hematology
Osamu Kurihara, Fumitaka Okajima, Masamichi Takano, Katsuhito Kato, Ryo Munakata, Daisuke Murakami, Yasushi Miyauchi, Naoya Emoto, Hitoshi Sugihara, Yoshihiko Seino, Wataru Shimizu
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Meeting Abstract
Peripheral Vascular Disease
Fumitaka Okajima, Osamu Kurihara, Masamichi Takano, Hitoshi Sugihara, Naoya Emoto
ATHEROSCLEROSIS SUPPLEMENTS
(2018)
Article
Gastroenterology & Hepatology
Masanori Atsukawa, Akihito Tsubota, Tomomi Okubo, Taeang Arai, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Keizo Kato, Tsutomu Hatori, Hiroshi Hano, Tsunekazu Oikawa, Naoya Emoto, Masanori Abe, Masayoshi Kage, Katsuhiko Iwakiri
HEPATOLOGY RESEARCH
(2018)
Article
Endocrinology & Metabolism
Fumitaka Okajima, Yuko Nakamura, Yuji Yamaguchi, Yuki Shuto, Katsuhito Kato, Hitoshi Sugihara, Naoya Emoto
Article
Endocrinology & Metabolism
Fumitaka Okajima, Yuko Nakamura, Yuji Yamaguchi, Yuki Shuto, Katsuhito Kato, Hitoshi Sugihara, Naoya Emoto
Article
Gastroenterology & Hepatology
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Mai Koeda, Yuji Yoshida, Tomomi Okubo, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Katsuhisa Nakatsuka, Takushi Masu, Keizo Kato, Noritomo Shimada, Tsutomu Hatori, Naoya Emoto, Masayoshi Kage, Katsuhiko Iwakiri
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Multidisciplinary Sciences
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Tadamichi Kawano, Mai Koeda, Yuji Yoshida, Tomohide Tanabe, Tomomi Okubo, Korenobu Hayama, Ai Iwashita, Norio Itokawa, Chisa Kondo, Keiko Kaneko, Chiaki Kawamoto, Tsutomu Hatori, Naoya Emoto, Etsuko Iio, Yasuhito Tanake, Katsuhiko Iwakiri
Article
Endocrinology & Metabolism
Hiroshi Yamada, Fumitaka Okajima, Takeshi Onda, Shunji Fujimori, Naoya Emoto, Hitoshi Sugihara
BMC ENDOCRINE DISORDERS
(2020)
Article
Endocrinology & Metabolism
Naoya Emoto, Akimi Soga, Izumi Fukuda, Kyoko Tanimura-Inagaki, Taro Harada, Hajime M. Koyano, Rei Goto, Hitoshi Sugihara
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Medicine, General & Internal
Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto
Summary: The study found that adding alogliptin to repaglinide monotherapy did not cause glucose-independent inappropriate insulin secretion and did not appear to increase the incidence of hypoglycemia in patients with type 2 diabetes.
JOURNAL OF NIPPON MEDICAL SCHOOL
(2021)
Article
Medicine, General & Internal
Naoya Emoto, Mikiko Okazaki-Hada, Yuji Yamaguchi, Fumitaka Okajima, Rei Goto, Hitoshi Sugihara
Summary: The study found that risk preferences of patients with thyrotoxicosis remain relatively stable in hyperthyroid and euthyroid states, but willingness to pay for medical costs may change after normalization of thyroid function.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Multidisciplinary Sciences
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Keizo Kato, Hiroshi Abe, Hirotaka Ono, Tadamichi Kawano, Yuji Yoshida, Tomohide Tanabe, Tomomi Okubo, Korenobu Hayama, Ai Nakagawa-Iwashita, Norio Itokawa, Chisa Kondo, Keiko Kaneko, Naoya Emoto, Mototsugu Nagao, Kyoko Inagaki, Izumi Fukuda, Hitoshi Sugihara, Katsuhiko Iwakiri
Summary: This study found that the severity of fibrosis in NAFLD is significantly and independently associated with high-risk CIMT. Non-invasive liver fibrosis markers and scoring systems may help estimate the risk of atherosclerosis progression in patients with NAFLD.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Kazuhiko Horiguchi, Yusaku Yoshida, Kenji Iwaku, Naoya Emoto, Toshihiko Kasahara, Junichiro Sato, Hiroki Shimura, Hisakazu Shindo, Satoru Suzuki, Hidekazu Nagano, Fumihiko Furuya, Noriko Makita, Fumihiko Matsumoto, Katsunori Manaka, Norisato Mitsutake, Megumi Miyakawa, Susumu Yokoya, Iwao Sugitani
Summary: Studies suggest that active surveillance is a safe and effective strategy for low-risk papillary thyroid microcarcinomas, preserving quality of life and reducing medical costs. However, high-risk cases should be closely monitored and surgery performed promptly during active surveillance.
Article
Endocrinology & Metabolism
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Shigeru Mikami, Hiroki Ono, Tadamichi Kawano, Yuji Yoshida, Tomohide Tanabe, Tomomi Okubo, Korenobu Hayama, Ai Nakagawa-Iwashita, Norio Itokawa, Chisa Kondo, Keiko Kaneko, Naoya Emoto, Mototsugu Nagao, Kyoko Inagaki, Izumi Fukuda, Hitoshi Sugihara, Katsuhiko Iwakiri
Summary: The study demonstrated that SGLT2-Is therapy can significantly improve liver inflammation, fatty changes, and fibrosis in patients with NAFLD, indicating their potential superiority to other oral hypoglycemic agents in addressing these conditions.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Tomoko Nagamine, Jaeduk Yoshimura Noh, Naoya Emoto, Takahito Kogai, Akira Hishinuma, Fumitaka Okajima, Hitoshi Sugihara
