Article
Endocrinology & Metabolism
Eva C. Coopmans, Mark R. Postma, Thalijn L. C. Wolters, Sebastiaan W. F. van Meyel, Romana Netea-Maier, Andre P. van Beek, Sebastian J. C. M. M. Neggers
Summary: The study identified that the size of the tumor and random GH concentration at diagnosis are closely related to remission after TSS in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Computer Science, Information Systems
Jia-Jung Wang, Shing-Hong Liu, Yong-Hong Pan, Wei-Kung Tseng, Wenxi Chen
Summary: Endothelial dysfunction is a significant risk factor in the development of atherosclerosis, hypertension, and heart failure. Brachial-artery ultrasound scanning is the preferred method to assess flow-mediated vasodilation, but the cuff method may overestimate the percentage of vasodilation.
Article
Clinical Neurology
Sven Berkmann, Joel Brun, Philipp Schuetz, Emanuel Christ, Luigi Mariani, Beat Mueller
Summary: This study evaluated the prevalence and course of hypertension, obesity, diabetes mellitus, obstructive sleep apnea syndrome, carpal tunnel syndrome, and polyposis coli in acromegalic patients. Surgical treatment led to remission in some patients, while drug therapy was more effective, but many comorbidities persisted.
ACTA NEUROCHIRURGICA
(2021)
Review
Endocrinology & Metabolism
Christos Papaioannou, Maralyn Druce
Summary: This review analyzes and evaluates the current evidence for the use of preoperative medications and different surgical approaches in acromegaly. The use of somatostatin receptor agonists (SAs) as preoperative treatment for acromegaly is controversial, with guidelines suggesting against their routine use. However, SAs have been found to reduce tumor volume and aid in total adenoma resection for invasive macroadenomas. Furthermore, endoscopic transsphenoidal surgery is considered the optimal method for hypophysectomy in terms of remission and safety profile.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yang Liu, Liang-Liang Tang, Chen Liang, Ming-Ming Wu, Zhi-Ren Zhang
Summary: Antiangiogenic tyrosine kinase inhibitors like sunitinib induce hypertension by causing vascular dysfunction and insulin resistance, leading to decreased endothelium-dependent relaxation and inhibition of AKT/eNOS/NO signaling. This study in rats showed that sunitinib administration resulted in elevated blood pressure, abnormal metabolism, and hormone levels, providing insights into the mechanisms underlying sunitinib-induced endothelial dysfunction and hypertension.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Andrology
Wei-Jie Su, Hong-Cai Cai, Guo-Chen Yang, Ke-Jun He, Hong-Lin Wu, Yi-Bing Yang, Hong-Xing Tang, Li-Xuan Yang, Chun-Hua Deng
Summary: This study aimed to investigate the outcomes of male patients with prolactinomas after transsphenoidal surgery and the risk factors affecting sexual dysfunction. Tumor size and invasiveness were found to be important factors affecting the improvement of sexual dysfunction, and preoperative testosterone level was an independent predictor related to the improvement of erectile dysfunction.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jiwon Kim, Yoon-a Hwang, Yae Won Park, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Cheol Ryong Ku
Summary: This retrospective study found that different GH nadir cut-offs were associated with prognosis in patients with acromegaly. A strict GH nadir threshold of 0.4 mu g/L correlated better with remission.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Jacobo Kerbel, Amayrani Cano-Zaragoza, Rodrigo Espinosa-Dorado, Keren-Enid Garcia de la Torre, Moises Mercado
Summary: National registries are valuable tools to investigate rare conditions like acromegaly, providing insights into epidemiology, clinical presentation, diagnosis, treatment outcomes, and mortality. While single-center studies are more homogeneous, they are often limited by small sample sizes and lack statistical power.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Clinical Neurology
Xiaopeng Guo, Ruopeng Zhang, Duoxing Zhang, Zihao Wang, Lu Gao, Yong Yao, Kan Deng, Xinjie Bao, Ming Feng, Zhiqin Xu, Yi Yang, Wei Lian, Renzhi Wang, Wenbin Ma, Bing Xing
Summary: This study investigated treatment outcomes following initial TSS for acromegaly, identifying predictors of immediate and long-term remission. Factors such as age, sex, tumor characteristics, and surgical approach were found to influence remission rates, with endoscopic TSS predicting higher long-term remission. Five outcome patterns were identified during follow-up, providing insights for clinical decision-making.
JOURNAL OF NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Cardiac & Cardiovascular Systems
Yongshun Wang, Jingjin Liu, Huadong Liu, Xin Sun, Ruimian Chen, Bihong Liao, Xiaoyi Zeng, Xiaoxin Zhang, Shaohong Dong, Zhengyuan Xia, Jie Yuan
Summary: Endothelial cells are sensitive to hemodynamic shear stresses and can be affected by disturbed flow-induced shear stress. This study found that TXNIP levels were increased in patients with slow coronary flow and in endothelial cells exposed to disturbed flow. Deletion of TXNIP in endothelial cells had beneficial effects on vascular formation, nitric oxide production, mitochondrial function, oxidative stress response, and glucose utilization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Nazanin Ershadinia, Nicholas A. Tritos
Summary: Acromegaly is a condition caused by a pituitary adenoma that secretes growth hormone, resulting in various complications. Early diagnosis and appropriate treatment are crucial. Diagnosis is confirmed through biochemical tests and MRI. Pituitary surgery is usually the first-line treatment, while medical therapy and radiation therapy can be used as adjunct options.
MAYO CLINIC PROCEEDINGS
(2022)
Review
Endocrinology & Metabolism
Maria Fleseriu, Fabienne Langlois, Dawn Shao Ting Lim, Elena V. Varlamov, Shlomo Melmed
Summary: Acromegaly, caused by growth hormone-secreting pituitary adenomas, is usually benign but can be locally invasive and progressive. It leads to a wide range of comorbidities and the normalization of growth hormone and insulin-like growth factor 1 is the primary therapeutic goal. A multimodal approach with surgery, medical therapy, and radiation therapy is required for optimal outcomes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)