Review
Nutrition & Dietetics
Maria Elena Capra, Brigida Stanyevic, Antonella Giudice, Delia Monopoli, Nicola Mattia Decarolis, Susanna Esposito, Giacomo Biasucci
Summary: Long-chain polyunsaturated fatty acids (LCPUFAs) have been extensively studied in adults for their positive effects on heart health, especially in secondary prevention after a cardiac event. LCPUFAs can be safely consumed either through food or as supplements without adverse effects. Their effects on global health have also been recognized in pediatric patients, but their cardiovascular effects in childhood are still not well-studied. Nutritional and lifestyle interventions, including the consumption of specific nutrients such as LCPUFAs, can play a role in cardiovascular risk prevention in developmental age, particularly in conditions like weight excess and dyslipidemia.
Article
Endocrinology & Metabolism
Ambika P. Ashraf, Bhuvana Sunil, Vaneeta Bamba, Emily Breidbart, Preneet Cheema Brar, Stephanie Chung, Anshu Gupta, Aditi Khokhar, Seema Kumar, Marissa Lightbourne, Manmohan K. Kamboj, Ryan S. Miller, Nivedita Patni, Vandana Raman, Amy S. Shah, Don P. Wilson, Brenda Kohn
Summary: Pediatric endocrinologists play a crucial role in early intervention for dyslipidemia in children, with different treatment strategies needed for various cases. Timely identification and management are extremely important for preventing cardiovascular disease in at-risk youth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biotechnology & Applied Microbiology
Xiaozhi Hu, Jiajun Fan, Qianqian Ma, Lei Han, Zhonglian Cao, Caili Xu, Jingyun Luan, Guangjun Jing, Yanyang Nan, Tao Wu, Yuting Zhang, Hanqi Wang, Yuanzhen Zhang, Dianwen Ju
Summary: This study developed a nanobody-heavy chain antibody to inhibit ANGPTL3 for the treatment of NAFLD. The antibody fusion protein reduced blood lipid levels and improved hepatic lipid accumulation and liver injury in a NAFLD mouse model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongxue Shi, Russell A. Prough, Craig J. McClain, Ming Song
Summary: This study aimed to investigate the combined effects of different types of dietary fat and fructose on the development of NAFLD in a murine model. Results showed that mice fed with high-saturated fat diet exhibited severe hepatic steatosis and liver injury, while fructose supplementation exacerbated liver fibrosis. Mice fed with omega-6 polyunsaturated fat diet combined with fructose showed impaired glucose tolerance. In summary, excessive intake of fat and fructose has negative effects on liver health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Anastasios Liberis, Stamatis Petousis, Panagiotis Tsikouras
Summary: Dyslipidemia in pregnancy poses risks for both mother and fetus, with increases in LDL-C and triglyceride levels requiring monitoring. Dietary control is the primary management approach, while apheresis may be considered for severe cases. Further research on the safety of lipid-lowering agents during pregnancy is needed.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Medicine, General & Internal
Yasufumi Tomioka, Koji Kitazawa, Yohei Yamashita, Kohsaku Numa, Takenori Inomata, Jun-Wei B. Hughes, Rina Soda, Masahiro Nakamura, Tomo Suzuki, Norihiko Yokoi, Chie Sotozono
Summary: Dry eye is a common age-related ocular surface disease with multiple factors involved. Dyslipidemia, specifically high total cholesterol (TC) and high triglycerides (TG), are significant risk factors for meibomian gland dysfunction (MGD), while high low-density lipoprotein (LDL) and low high-density lipoprotein (HDL) are not identified as risk factors. This systematic review and meta-analysis provide further evidence on the relationship between lipid abnormalities and MGD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Asahiro Morishita, Kyoko Oura, Kei Takuma, Mai Nakahara, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tingting Shi, Takashi Himoto, Miwa Tatsuta, Akio Moriya, Tomonori Senoo, Akemi Tsutsui, Takuya Nagano, Koichi Takaguchi, Masafumi Ono, Tsutomu Masaki
Summary: This retrospective, multicenter study evaluated the effect of pemafibrate treatment on liver function and fibrosis in NAFLD patients with hypertriglyceridemia. The results showed that pemafibrate improved liver function and fibrotic biomarkers, suggesting its potential in preventing disease progression in NAFLD patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yuanlu Shu, Xiang Zhao, Changshun Yang, Yan Yan, Yao Zheng, Xijie Wang, Chengfeng Qiu
Summary: Recent evidence suggests that elevated serum PK levels are associated with the likelihood of hypercholesterolemia and hypertriglyceridemia. A nonlinear relationship between serum PK and HDL-C levels was observed. Higher levels of PK may be a risk factor for cardiovascular diseases.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Oncology
Takatoshi Anno, Tomoki Yamatsuji, Koichi Tomoda, Shuhei Nakanishi, Hideaki Kaneto
Summary: This report presented a case of dyslipidemia induced by capecitabine in a patient with sigmoid colon cancer. The patient's dyslipidemia, characterized by markedly elevated LDL-cholesterol and unstable triglyceride levels during treatment, was ameliorated by rosuvastatin, an HMG-CoA reductase inhibitor.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Bhuvana Sunil, Christy Foster, Don P. Wilson, Ambika P. Ashraf
Summary: Landmark studies have shown that atherosclerosis begins in youth and more youth with lipid and lipoprotein disorders are being identified through screening. Existing lipid-lowering therapy for youth is safe but response may vary, indicating a need for new agents and approaches. Clinical trials on novel therapeutic agents for cholesterol and triglycerides are ongoing in youth, with a focus on altering lipid and lipoprotein metabolism.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Sijeong Bae, Young-Ah Moon
Summary: This study suggests that the deletion of Elovl5 leads to hepatic steatosis and dyslipidemia, which are the major factors in severe atherosclerosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Gastroenterology & Hepatology
Eunice Zhi-Yi Tan, Lee-Lee Lai, Shireene Ratna Vethakkan, Nik Raihan Nik Mustapha, Sanjiv Mahadeva, Wah-Kheong Chan
Summary: Modest alcohol intake is not associated with a higher prevalence of significant hepatic steatosis or more severe liver disease among patients with T2DM. Modest drinkers were more likely to be male, smokers, and had lower glycated hemoglobin, total cholesterol, low-density lipoprotein cholesterol, alkaline phosphatase, and platelet count. Prevalence of modest drinking was similar among ethnic Indians and Chinese but rare among ethnic Malays.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Fadlina Chany Saputri, Nuriza Ulul Azmi, Meidi Utami Puteri, Gracia Damayanti, Vivi Novita, Gracia Marisi, Elin Oktavira, Aninda Novika Sari, Khairunisa Ronaningtyas, Enny Herawati
Summary: This study assessed the impact of a high-fat diet on platelet activation and its association with PCSK9, as well as its effects on blood pressure in an animal model. The results showed that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia significantly increased platelet activation and PCSK9 levels. These findings suggest a potential link between high-fat diet, PCSK9, and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Jianqin Zhong, Leilei Liu, Linyuan Zhang, Zixuan Xu, Lian Peng, Xiaolan Zhao, Qianyuan Yang, Tingting Yang, Degan Xu, Feng Hong
Summary: This study examines the link between urinary zinc concentration and the risk of developing dyslipidemia and its subtypes in China's ethnic minority residents. The findings suggest a non-linear relationship between urinary zinc concentration and hypertriglyceridemia and hyperbetalipoproteinemia. In certain subgroups, higher urinary zinc levels are associated with an increased risk of dyslipidemia.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medical Laboratory Technology
Samuel Doiron, Martine Paquette, Alexis Baass, Guillaume Bollee, Heloise Cardinal, Sophie Bernard
Summary: This study investigated the association between the magnitude of proteinuria and PCSK9 concentrations. The results showed that PCSK9 was significantly elevated in patients with nephrotic syndrome and was associated with a detrimental lipid profile.
CLINICAL BIOCHEMISTRY
(2022)