Article
Biochemistry & Molecular Biology
Ying Li, Anna De Bolos, Virginia Amador, David Reverter
Summary: SUMO proteases or deSUMOylases regulate the lifetime of SUMO-conjugated targets in the cell. In humans, the deSUMOylating activity is mainly conducted by the SENP/ULP protease family, with SENP6 and SENP7 having unique preference for SUMO2/3 isoforms and activity for dismantling polySUMO2 chains.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Plant Sciences
Moumita Srivastava, Ari Sadanandom, Anjil Kumar Srivastava
Summary: The translation discusses the critical role of post-translational modifications (PTMs) in regulating plant growth and development, and the challenges in understanding the functional implications of PTMs on plant cellular signaling.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Multidisciplinary Sciences
Dan Tan, Meiping Lu, Yuqing Cai, Weibo Qi, Fugen Wu, Hangyang Bao, Meiyu Qv, Qiangqiang He, Yana Xu, Xiangzhi Wang, Tingyu Shen, Jiahao Luo, Yangxun He, Junsong Wu, Lanfang Tang, Muhammad Qasim Barkat, Chengyun Xu, Ximei Wu
Summary: Allergic asthma is characterized by goblet cell metaplasia. Here, the authors show protein SUMOylation contributes to goblet cell metaplasia and SUMOylation-mediated ROCK2 activation is an integral component of Rho/ROCK signaling pathway in controlling the airway goblet cell metaplasia.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Shi, Miersalijiang Yasen, Zhijun Wang, Tingting Du, Yelei Ding, Xuefei Li, Zongtao Chai, Chen Jie, Guanqun Ju, Mingfei Ji
Summary: Molecular dynamics simulations were performed to investigate the conformational dynamics of SENP1-SUMO1, SENP1-SUMO2, and apo SENP1 systems. Stronger interactions between SENP1 and SUMO1 were observed, which may explain the preference of SENP1 for processing SUMO1 over SUMO2. An allosteric propagation model was proposed to explain the substrate discrimination of SENP1.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Qi, Haijing Guan, Xiuying Liang, Jingwen Sun, Wenjuan Yao
Summary: This study revealed that Uba2 or Aos1 suppression significantly inhibited Ang II-induced SUMO2/3 modification of RhoGDI1 and cell proliferation, while not affecting SUMO1 modification. Additionally, Uba2 or Aos1 suppression promoted RhoGDI1 ubiquitination and degradation. These findings suggest that SUMO2/3 modification plays a key role in regulating RhoGDI1 stability and cell proliferation, while SUMO1 modification does not participate in these processes.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Da Xu, Jing Bi, Yunfeng Guan, Xiaotong Luo, Xuan Chen, Yanqiu Lv, Yi Jin
Summary: The study found that UBA2 can influence the maturation rate of pig oocytes, expression of apoptosis genes, cumulus cell viability, and embryonic development by regulating the content of SUMO-1 protein in mature pig oocytes in vitro.
ANIMAL SCIENCE JOURNAL
(2021)
Article
Multidisciplinary Sciences
Mahrou Sadri, Haichuan Wang, Toshinobu Kuroishi, Yong Li, Janos Zempleni
Summary: HLCS deficiency can lead to severe carboxylase deficiency, but early diagnosis and biotin treatment can prevent fatal consequences. This study successfully developed an HLCS conditional knockout mouse model and found that HLCS knockout has lethal effects on embryo survival.
Article
Biochemistry & Molecular Biology
Yulong Chong, Chunran Zhu, Wei Hu, Chengrong Jiang, Weibang Liang, Zongjing Zhu
Summary: This study suggests that miR-212-5p plays a suppressive role in glioma development by regulating the expression of SUMO2, thereby affecting the proliferation, migration, and apoptosis of glioma cells. This finding may contribute to the identification of novel therapeutic targets for glioma.
BIOCHEMICAL GENETICS
(2023)
Article
Virology
Marie Fiedler, Wing-Hang Ip, Helga Hofmann-Sieber, Britta Wilkens, Francis K. Nkrumah, Wenli Zhang, Anja Ehrhardt, Luca D. Bertzbach, Thomas Dobner
Summary: The human adenovirus type C5 (HAdV-C5) E1B-55K protein is a multifunctional regulator of HAdV-C5 replication, with phosphorylation and SUMO conjugation playing important roles in its functions. The interaction between E1B-55K and E4orf6 inhibits SUMOylation of E1B-55K, which may promote viral replication.
Article
Neurosciences
Guiliang Sun, Weiwei Qin, Qiang Wang, Xiaopeng Sun, Huailong Chen, Jingzhu Li, Lixin Sun, Fei Shi, Gaofeng Zhang, Mingshan Wang
Summary: Selective cerebral hypothermia has been shown to reduce neuronal injury caused by I/R, mainly by increasing SUMO2/3 modification through down-regulation of SENP3 expression in rats with cerebral I/R injury.
Article
Biochemistry & Molecular Biology
Chen Huang, Bo Zhu, Dongliang Leng, Wei Ge, Xiaohua Douglas Zhang
Summary: Our study uncovered several lncRNAs affected by Ybx1 disruption that may target redox-related genes, leading to morphological deformations in zebrafish embryos, shedding new insights into the mechanisms underlying development in Ybx1-deficient zebrafish larvae.
Article
Reproductive Biology
Ying Yang, Yingbing Zhang, Peipei Qiao, Bin Yang, Huiqun Jia, Yong Zhang, Jun Zhang, Jianmin Su
Summary: SUMO2 plays a significant role in mouse preimplantation embryos, potentially affecting embryonic development through key epigenetic modifications and regulation of pluripotency genes.
Article
Biochemistry & Molecular Biology
Szymon W. Kmiecik, Katarzyna Drzewicka, Frauke Melchior, Matthias P. Mayer
Summary: The heat shock response is a transcriptional program of organisms to counteract protein homeostasis imbalance, regulated by the transcription factor Hsf1. Post-translational modifications such as phosphorylation and SUMOylation are proposed mechanisms to regulate Hsf1 activity. SUMOylation at lysine 298, enhanced by trimerization and phosphorylation, affects Hsf1 efficiency in response to stress.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biology
Tunahan Ergunay, Ozgecan Ayhan, Arda B. Celen, Panagiota Georgiadou, Emre Pekbilir, Yusuf T. Abaci, Duygu Yesildag, Mandy Rettel, Ulduz Sobhiafshar, Anna Ogmen, N. C. Tolga Emre, Umut Sahin
Summary: This study reports the discovery of Cas9 sumoylation and ubiquitylation, which can regulate the stability and DNA binding efficacy of the enzyme.
LIFE SCIENCE ALLIANCE
(2022)
Article
Cell Biology
Jack-Christophe Cossec, Tatiana Traboulsi, Sebastien Sart, Yann Loe-Mie, Manuel Guthmann, Ivo A. Hendriks, Ilan Theurillat, Michael L. Nielsen, Maria-Elena Torres-Padilla, Charles N. Baroud, Anne Dejean
Summary: Recent advances in synthetic embryology have revealed that chemical inhibition of SUMOylation in mouse embryonic stem cells (ESCs) can lead to the generation of embryo-like structures. These structures can self-organize into gastrulating structures and undergo axial organization reminiscent of natural embryo morphogenesis. This approach provides a proof of principle for exploring early embryogenesis by targeting chromatin roadblocks of cell fate change.