期刊
EMBO REPORTS
卷 15, 期 6, 页码 670-677出版社
WILEY
DOI: 10.1002/embr.201338142
关键词
mitochondria; Om45; translocator; yeast
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Japan Science and Technology Corporation (JST)
- Grants-in-Aid for Scientific Research [24657072, 25870311, 22227003] Funding Source: KAKEN
The membrane topology of Om45 in the yeast mitochondrial outer membrane ( OM) is under debate. Here, we confirm that Om45 is anchored to the OM from the intermembrane space (IMS) by its N-terminal hydrophobic segment. We show that import of Om45 requires the presequence receptors, Tom20 and Tom22, and the import channel of Tom40. Unlike any of the known OM proteins, Om45 import requires the TIM23 complex in the inner membrane, a translocator for presequence-containing proteins, and the membrane potential (Delta Psi). Therefore, Om45 is anchored to the OM via the IMS by a novel import pathway involving the TIM23 complex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据