Complex diseases require complex therapies

Pipeline for COPD drugs flows with combination candidates

(2013) Helen Thompson   NATURE MEDICINE

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

(2013) S. Zhao et al.   Science Translational Medicine

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels

(2011) N P Tatonetti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

A Positive Feedback Signal Transduction Loop Determines Timing of Cerebellar Long-Term Depression

(2008) Keiko Tanaka et al.   NEURON