期刊
EMBO REPORTS
卷 14, 期 12, 页码 1113-1119出版社
WILEY
DOI: 10.1038/embor.2013.165
关键词
oxidative stress response; polyamines; cell cycle arrest; metabolite export; timing
资金
- Max Planck Society
- Isaac Newton Trust
- Wellcome Trust [RG 093735/Z/10/Z]
- ERC [260809]
- MRC [MC_UP_1202/8] Funding Source: UKRI
- Medical Research Council [MC_UP_1202/8] Funding Source: researchfish
- European Research Council (ERC) [260809] Funding Source: European Research Council (ERC)
Cells counteract oxidative stress by altering metabolism, cell cycle and gene expression. However, the mechanisms that coordinate these adaptations are only marginally understood. Here we provide evidence that timing of these responses in yeast requires export of the polyamines spermidine and spermine. We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1-controlled polyamine export.
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