期刊
EMBO REPORTS
卷 13, 期 4, 页码 386-391出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2012.17
关键词
T cells; Sos; Grb2; RasGRP1; Erk
资金
- German Research Foundation (DFG) [FOR-521 [SI861/1], GRK-1167 [TP12], SFB-854 [TP19]]
Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/ Sos. Conversely, Grb2/Sos-but not RasGRP1-are required for IL2-mediated Erk activation. Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR.
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