期刊
EMBO REPORTS
卷 13, 期 7, 页码 645-652出版社
WILEY
DOI: 10.1038/embor.2012.72
关键词
cohesion; Pds5; Eso1; Psm3; Wapl
资金
- Centre National de la Recherche Scientifique
- l'Universite Victor Segalen
- la Region Aquitaine
- l'Association pour la Recherche sur le Cancer
- l'Agence Nationale de la Recherche
- Ministere de la Recherche et de l'Enseignement Superieur
Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated chromosomes. The latter requires Eso1 only in the presence of Wapl, indicating that cohesin stabilization relies on Eso1 only to neutralize the anti-establishment activity. We suggest that Eso1 requires Pds5 to counteract anti-establishment. This allows both cohesion establishment and Pds5-dependent stable cohesin binding to chromosomes.
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