Review
Cell Biology
Shudong Zhu, Rong Sun, Xialing Guo, Yuanwu Bao, Dianzheng Zhang
Summary: This article summarizes the important roles of Src family kinases (SFKs) in multiple signaling pathways, with a focus on the inhibitory function of CHK in tumor development and its regulation of various substrates. Although the precise functions of CHK are still unclear, it has been found to allosterically inhibit Src kinase activity and is regulated through promoter methylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Respiratory System
Miguel A. Hernandez-Lara, Santosh Kumar Yadav, Stanley Conaway Jr, Sushrut D. D. Shah, Raymond B. Penn, Deepak A. Deshpande
Summary: This study reveals the molecular pathway (DAG-PKC/ERK-COXII-PGE(2)-PKA) regulated by DGK in airway smooth muscle cells, and identifies DGK as a potential therapeutic target for mitigating ASM cell proliferation that contributes to airway remodeling in asthma.
RESPIRATORY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jingzhen Yuan, Chintan Chheda, Grace Tan, Omer Elmadbouh, Stephen J. Pandol
Summary: The study reveals that alcohol abuse can enhance PKD signaling in pancreatitis, leading to exacerbated pathological responses. Inhibition of PKD activation through pharmacological means or genetic deletion prevents the detrimental effects of alcohol on NF-KB activation, inflammatory responses, and cell necrosis, thereby mitigating the severity of alcoholic pancreatitis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
Yixin Wang, Jing Xiu, Chune Ren, Zhenhai Yu
Summary: PIM2 kinase is a key oncogene in multiple cancers, promoting transcriptional activation of genes involved in cell survival, proliferation, and cell-cycle progression. Numerous tumorigenic signaling molecules have been identified as substrates for PIM2 kinase, leading to the development of various inhibitors. PIM2 is poised to become a therapeutic target in cancer treatment in the future.
Article
Biochemistry & Molecular Biology
Taiji Sato, Chihiro Ishiwatari, Yukiko K. Kaneko, Yoko Ishikawa, Yuki Kimura, Naoya Watanabe, Ikumi Aoshima, Yukari Matsuda, Takahiro Nakayama, Rina Chiba, Takahiro Fujinuki, Kai Iwata, Qiang Lu, Takako Usuki, Fumio Sakane, Tomohisa Ishikawa
Summary: The study revealed that DGK delta plays a key role in regulating beta-cell mass, with knockout resulting in improved insulin levels and glucose tolerance. Inhibiting DGK delta may be a novel therapeutic approach for increasing beta-cell mass in diabetes treatment.
Article
Chemistry, Medicinal
Christian Borgo, Luca Cesaro, Tsuyoshi Hirota, Keiko Kuwata, Claudio D'Amore, Thomas Ruppert, Renata Blatnik, Mauro Salvi, Lorenzo A. Pinna
Summary: CK2, a protein kinase with pleiotropic functions, is implicated in global human pathologies, particularly cancer. Selective inhibitors like CX4945 and GO289 show promise in controlling the CK2-dependent phosphoproteome.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A. Rockman
Summary: This review explores the signaling pathways, dynamic structures, and physiological relevance of the three most important GPCR signaling effectors in the cardiovascular system: heterotrimeric G proteins, GPCR kinases (GRKs), and 8-arrestins. It summarizes their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. The application of new technologies has contributed to an increasing understanding of GPCR structure and downstream effectors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Huilin Cui, Yige Huang, Ying Wu, Jinfeng Ma, Ximei Cao, Jianshan Xie, Yu Zhang
Summary: The study revealed that the four DGK isozymes play important roles in the process of experimental autoimmune encephalomyelitis (EAE). DGKα and DGKζ may regulate the pathological process by attenuating DAG/PKC delta pathway signaling during EAE evolution.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Review
Cell Biology
Yuichi Wakana, Felix Campelo
Summary: Membrane trafficking plays a crucial role in processing and transporting proteins and lipids, as well as in establishing cell compartmentation and tissue organization. The focus of this review is on a specific membrane trafficking route from the trans-Golgi network to the cell surface, highlighting the role of PKD-dependent pathway and membrane contact sites in this process. Additionally, the discussion includes various signaling pathways involved in regulating membrane trafficking, such as those mediated by PKD, GPCRs, growth factors, metabolites, and mechanosensors.
Article
Biochemistry & Molecular Biology
Miguel Angel Hernandez-Lara, Santosh K. Yadav, Sushrut D. Shah, Mariko Okumura, Yuichi Yokoyama, Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande
Summary: Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. The inhibition of diacylglycerol kinase (DGK) reduces the conversion of diacylglycerol (DAG) into phosphatidic acid (PA) and inhibits ASM cell proliferation. These findings suggest that DGK may serve as a potential drug target for mitigating airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Song-Yang Zhang, Tony K. T. Lam
Summary: A study found that intestinal epithelium-specific AMPK alpha 1 knockout mice do not respond to metformin and exhibit disruptions in metabolic homeostasis due to changes in the gut microbiome. This highlights the therapeutic potential of targeting intestinal AMPK for diabetes.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jin-Gyeong Park, Hanul Jeon, Sangchul Shin, Chiman Song, Hyomin Lee, Nak-Kyoon Kim, Eunice EunKyeong Kim, Kwang Yeon Hwang, Bong-Jin Lee, In-Gyun Lee
Summary: This study identified a conserved region of CEP192 that interacts with AURKA and revealed the structural basis for CEP192-mediated regulation of AURKA at the centrosome. This regulation is distinct from TPX2-mediated regulation on the spindle microtubule.
Review
Biochemistry & Molecular Biology
Xuejing Zhang, Jaclyn Connelly, Yapeng Chao, Qiming Jane Wang
Summary: Protein kinase D (PKD) is a crucial family of protein kinases involved in various cell signaling pathways, dysregulation of which can lead to multiple diseases. Research indicates that PKD plays a key role in pathological conditions like cancer, highlighting the importance of understanding its biological significance for developing more effective therapies.
Article
Oncology
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Summary: Studies have shown that mice deficient in DGK zeta exhibit better control of tumors, and deficiency of DGK zeta acts additively with anti-PD1 in tumor control. Additionally, DGK zeta imparts greater regulation in human T cells compared to DGK alpha.
Article
Biochemistry & Molecular Biology
Pawan Sharma, Santosh K. Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande
Summary: This study demonstrated that inhibition of DGK disrupted the DAG:PA ratio, resulting in the inhibition of Gq-PLC activation in a negative feedback manner, thus protecting against ASM contraction.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
