Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

(2011) Mikael Lerner et al.   CELL CYCLE

Wnt to Notch Relay Signaling Induces Definitive Hematopoiesis

(2011) Dirk Loeffler et al.   Cell Stem Cell

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer

(2011) P. M. McGowan et al.   MOLECULAR CANCER RESEARCH

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) Konstantinos J Mavrakis et al.   NATURE GENETICS

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Turning straw into gold: directing cell fate for regenerative medicine

(2011) Dena E. Cohen et al.   NATURE REVIEWS GENETICS

The functional role of Notch signaling in human gliomas

(2011) M.-T. Stockhausen et al.   NEURO-ONCOLOGY

Concise Review: Emerging Concepts in Clinical Targeting of Cancer Stem Cells

(2011) Zeshaan A. Rasheed et al.   STEM CELLS

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7  overexpression

(2010) H. Iriuchishima et al.   BLOOD

Hematopoietic stem cell transplantation for multiple myeloma beyond 2010

(2010) J. Blade et al.   BLOOD

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

Breast Cancer Stem Cells: Something Out of Notching?

(2010) H. Harrison et al.   CANCER RESEARCH

Hematopoietic Stem Cell Heterogeneity: Subtypes, Not Unpredictable Behavior

(2010) Timm Schroeder   Cell Stem Cell

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

(2010) Ichiro Onoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex

(2010) Linsey Reavie et al.   NATURE IMMUNOLOGY

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Stem cell therapies for spinal cord injury

(2010) Vibhu Sahni et al.   Nature Reviews Neurology

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

(2010) V Rocher-Ros et al.   ONCOGENE

The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

(2010) K M Crusio et al.   ONCOGENE

p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases

(2009) T. Yokobori et al.   CANCER RESEARCH

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb

(2009) K Kitagawa et al.   ONCOGENE

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

(2008) J. M. Perry et al.   GENES & DEVELOPMENT

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation

(2008) Chie Kanei-Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse differentiating spermatogonia can generate germinal stem cells in vivo

(2008) Vilma Barroca et al.   NATURE CELL BIOLOGY

Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy

(2008) S Finkin et al.   ONCOGENE

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE

Human ESC vs. iPSC—Pros and Cons

(2008) Jane J. Pappas et al.   Journal of Cardiovascular Translational Research

Signaling pathways governing stem-cell fate

(2007) U. Blank et al.   BLOOD