期刊
EMBO REPORTS
卷 13, 期 1, 页码 83-89出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.223
关键词
haemocyte; haematopoietic niche; FoxO; ROS; Spitz
资金
- Broad Stem Cell Research Center
- National Institutes of Health [5R01 HL067395]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL067395] Funding Source: NIH RePORTER
Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
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