期刊
EMBO REPORTS
卷 12, 期 2, 页码 157-163出版社
WILEY
DOI: 10.1038/embor.2010.188
关键词
polyhomeotic; non-autonomous cell overproliferation; JAK/STAT pathway; Notch signalling; Upd homologues
资金
- March of Dimes Foundation [1-FY07-477]
- National Science Foundation [ISO1021767]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [821250] Funding Source: National Science Foundation
Polycomb group (PcG) proteins are conserved epigenetic regulators that are linked to cancer in humans. However, little is known about how they control cell proliferation. Here, we report that mutant clones of the PcG gene polyhomeotic (ph) form unique single-cell-layer cavities that secrete three JAK/STAT pathway ligands, which in turn act redundantly to stimulate overproliferation of surrounding wild-type cells. Notably, different ph alleles cause different phenotypes at the cellular level. Although the ph-null allele induces non-autonomous overgrowth, an allele encoding truncated Ph induces both autonomous and non-autonomous overgrowth. We propose that PcG misregulation promotes tumorigenesis through several cellular mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据