期刊
EMBO MOLECULAR MEDICINE
卷 6, 期 12, 页码 1521-1524出版社
WILEY-BLACKWELL
DOI: 10.15252/emmm.201404749
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资金
- NHLBI NIH HHS [R01 HL102738, HL091469, R01 HL067724, HL112330, HL067724, R01 HL112330, HL102738, R01 HL091469] Funding Source: Medline
- NIA NIH HHS [R01 AG023039, AG023039] Funding Source: Medline
Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR-208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter etal, ). In their follow-up study in this issue of EMBO Molecular Medicine, white adipose tissue (WAT) and liver are identified as the physiological targets of cardiac MED13 signaling, most likely through cardiac-derived circulating factors, whichboost energy consumption by upregulating metabolic gene expression and increasing mitochondrial numbers (Baskin etal, ). In turn, increased energy expenditure in WAT and the liver confers leanness. These findings strengthen the evidence of metabolic crosstalk between the heart and peripheral tissues through cardiokines and also set the stage for the development of novel treatments for metabolic syndrome.
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