HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

From stem cells to cancer stem cells: HIF takes the stage

(2012) Kyoung Eun Lee et al.   CURRENT OPINION IN CELL BIOLOGY

Revisiting the differentiation paradigm in acute promyelocytic leukemia

(2011) J. Ablain et al.   BLOOD

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group

(2010) F. Lo-Coco et al.   BLOOD

PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia

(2010) Kankan Wang et al.   CANCER CELL

PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia

(2010) Joost H.A. Martens et al.   CANCER CELL

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

(2010) T T Marstrand et al.   LEUKEMIA

Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926

(2010) Tara L. Lin et al.   PLoS One

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group

(2008) M. A. Sanz et al.   BLOOD

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE