期刊
EMBO MOLECULAR MEDICINE
卷 2, 期 2, 页码 42-50出版社
WILEY-BLACKWELL
DOI: 10.1002/emmm.200900057
关键词
axonal transport; multiple sclerosis; myelin; proteolipid protein; visual system
资金
- Multiple Sclerosis Society (Scotland) Junior Fellowship
- DFG [SFB-TR43]
- BMBF
It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease. In this study we sought to characterize the relationship between demyelination, inflammation and axonal transport changes using a Pip1-transgenic mouse model of Pelizaeus-Merzbacher disease. in the optic pathway of this non-immune mediated model of demyelination, myelin loss progresses from the optic nerve head towards the brain, over a period of months. Axonal transport is functionally perturbed at sites associated with local inflammation and 'damaged' myelin. Surprisingly, where demyelination is complete, naked axons appear well preserved despite a significant reduction of axonal transport. Our results suggest that neuroinflammation and/or oligodendrocyte dysfunction are more deleterious for axonal health than demyelination per se, at least in the short term.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据