期刊
EMBO JOURNAL
卷 33, 期 15, 页码 1621-1623出版社
WILEY-BLACKWELL
DOI: 10.15252/embj.201489185
关键词
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资金
- NCI NIH HHS [CA80100, P30 CA014195, CA14195, R01 CA080100, R01 CA082683, CA82683] Funding Source: Medline
Pink1 and Parkin, identified through studies of hereditary early onset Parkinson's disease, are involved in mitochondria quality control. Parkin E3 ubiquitin ligase activity is activated by Pink1 kinase activity, although the mechanism is still elusive. Three recent reports uncover a surprising mechanism in which Pink1 directly phosphorylates ubiquitin to boost Parkin activity.
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