Article
Biochemistry & Molecular Biology
Mookwang Kwon, Ju Hyun Lee, Youngik Yoon, Samuel J. Pleasure, Keejung Yoon
Summary: Growing evidence suggests that the corticotropin-releasing hormone (CRH) signaling pathway plays an important role in embryonic brain development by regulating neural stem cell properties through increased expression of the master transcription factor REST. These findings highlight the significance of CRH signaling in the regulation of neural stem cells during embryonic brain development.
Article
Medicine, Research & Experimental
Julius Niehoff, Matthias Matzkies, Filomain Nguemo, Juergen Hescheler, Michael Reppel
Summary: This study is the first to demonstrate the influence of light on the beating rhythm of heart tissue in vitro. The results indicate that especially the infrared spectrum of light alters the BRV. These findings could be of interest for clinical applications such as the field of optical pacing as well as in neonatal patient care.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Computer Science, Information Systems
Marco Di Rienzo, Alberto Avolio, Giovannibattista Rizzo, Zeynep Melike Isilay Zeybek, Luisa Cucugliato
Summary: This study investigates the beat-to-beat relationships among Pulse Transit Times (PTTs) and Pulse Arrival Times (PATs) measured from different vascular districts, and their links with continuous blood pressure and isovolumic contraction time. The study finds that PTTs measured at different districts are uncorrelated at rest and during certain stressors. Dynamic exercise induces significant changes in PTTs and synchronizes their modulations. Similar trends are observed in PATs. The study suggests that pulse transit times are influenced by factors other than beat-to-beat blood pressure values.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Review
Behavioral Sciences
Jonathan J. Cannon, Aniruddh D. Patel
Summary: This study proposes that beat anticipation relies on action-like processes in the brain, orchestrated by neural time-keeping activity in the supplementary motor area (SMA) and the dorsal striatum. By synthesizing recent advances in cognitive science and motor neuroscience, the framework provides testable predictions for future research.
TRENDS IN COGNITIVE SCIENCES
(2021)
Review
Cell Biology
Kieran Maheden, Vivian Weixuan Zhang, Nika Shakiba
Summary: Stem cells face selective pressures that lead to the dominance of certain clones. Cell competition is a conserved mechanism to counteract these pressures. It has been observed in various mammalian tissue systems, but there are challenges in terms of terminology and capturing information flow. The use of next generation technologies can help bridge these gaps and further our understanding of cell competition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Physics, Applied
Jan Carmeliet, Dominique Derome
Summary: This article discusses the fact that over half of the world's population lives in cities, which tend to be hotter than rural areas. The authors, Jan Carmeliet and Dominique Derome, explain how physics modeling can help understand why cities get hot and suggest methods for cooling them.
NATURE REVIEWS PHYSICS
(2023)
News Item
Multidisciplinary Sciences
Liam Drew
Summary: Scientists track throat neurons that detect infection signs and transmit this information to the brain.
Article
Forestry
Patricia Povoa de Mattos, Rafaella De Angeli Curto, Evaldo Munoz Braz, Sylvio Pellico Netto
Summary: The objective of this study was to evaluate the growth and trunk shape at different stages of Araucaria angustifolia trees in overstocked stands. The research revealed that trees showed different growth patterns and changes in trunk shape as they outgrew their competition.
Article
Genetics & Heredity
Nanami Akai, Shizue Ohsawa, Yukari Sando, Tatsushi Igaki
Summary: The study found that in Drosophila Minute mutants, both cell death and compensatory cell proliferation are significantly increased during development, highlighting the essential role of cell-turnover in robust tissue growth.
Article
Engineering, Electrical & Electronic
Evan Ackerman
Summary: This passage describes the scene where the author is amazed by the high-speed flight of a drone created by the Robotics and Perception Group at the University of Zurich.
Article
Psychology, Mathematical
Roland Pfister, Anna Foerster
Summary: Post-error slowing is a widely used measure to study the cognitive and behavioral consequences of error commission. Different methods, such as traditional and more recent proposals, have been suggested to quantify this effect. Thorough re-analyses of datasets suggest that distinguishing between initial pre-error speeding and later post-error slowing is crucial for a more accurate assessment of human error processing.
BEHAVIOR RESEARCH METHODS
(2022)
Article
Cell Biology
Yanan Li, Baijie Xu, Mengmeng Jin, Hui Zhang, Ningxin Ren, Jinhui Hu, Jie He
Summary: Correct cell number generation is important for tissue development. In this study, the roles of coordinated proliferation of neural progenitors and the molecular mechanism were investigated in zebrafish. The results showed that overexpression of p15 led to expanded clones of donor retinal progenitor cells (RPCs) in the host retinae. Further analysis revealed that reduced levels of cell adhesion molecule 3 (cadm3) in p15(+) retinae suppressed clonal expansion, while overexpression of Cadm3 inhibited clonal expansion. The study highlights the importance of Cadm3 in regulating cell number homeostasis during neural tissue development.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Csobonyeiova, Nikoleta Beerova, Martin Klein, Michaela Debreova-Cehakova, L'ubos Danisovic
Summary: Heart failure is a major cause of morbidity and mortality in modern society due to cardiomyocyte death or dysfunction caused by myocardial infarction. Current therapies for heart failure or myocardial infarction are limited and non-curative. Therefore, research has focused on developing cell-based approaches, such as multipotent stem cells and induced pluripotent stem cells, for myocardial regeneration. Other potential sources for cardiac regeneration include telocytes and cell-free approaches, such as gene therapy and exosomes released from stem cells. This review provides insights into the novel strategies for myocardial repair based on different cell types and cell-free approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
James Fifer, Bastian Bentlage, Sarah Lemer, Atsushi G. Fujimura, Michael Sweet, Laurie J. Raymundo
Summary: The health of coral reefs globally is deteriorating due to factors like increasing sea surface temperature, with conspecific colonies showing varying responses based on factors such as water flow. High flow provides corals with health benefits and resilience to heat stress, resulting in better survival and recovery rates during bleaching events.
Review
Biochemistry & Molecular Biology
Ricardo D. Lardone, Yohana C. Garay, Pedro Parodi, Sofia de la Fuente, Genaro Angeloni, Eduardo O. Bravo, Anneke K. Schmider, Fernando J. Irazoqui
Summary: This review examines the relevance of various glycobiological molecules as potential therapeutic tools or inspirations during SARS-CoV-2 infection, emphasizing the critical roles of glycans in efficient infection between the virus and host cells. The article also critically evaluates the glycobiological contribution of candidate drugs for COVID-19 therapy, suggesting opportunities for repurposing FDA-approved drugs and discussing the possibility of biotechnological engineering of new probes to block SARS-CoV-2 infection based on essential insights into glycobiology.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Kristiaan J. Lenos, Daniel M. Miedema, Sophie C. Lodestijn, Lisanne E. Nijman, Tom van den Bosch, Xavier Romero Ros, Filipe C. Lourenco, Maria C. Lecca, Maartje van der Heijden, Sanne M. van Neerven, Anita van Oort, Nicolas Leveille, Ronja S. Adam, Felipe de Sousa E. Melo, Joy Otten, Patrick Veerman, Guillaume Hypolite, Lianne Koens, Scott K. Lyons, Giorgio Stassi, Douglas J. Winton, Jan Paul Medema, Edward Morrissey, Maarten F. Bijlsma, Louis Vermeulen
NATURE CELL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Linjie Zhao, Wei Wang, Lian Xu, Tao Yi, Xia Zhao, Yuquan Wei, Louis Vermeulen, Ajay Goel, Shengtao Zhou, Xin Wang
Article
Cell & Tissue Engineering
Carmen G. Palii, Qian Cheng, Mark A. Gillespie, Paul Shannon, Michalina Mazurczyk, Giorgio Napolitani, Nathan D. Price, Jeffrey A. Ranish, Edward Morrissey, Douglas R. Higgs, Marjorie Brand
Article
Multidisciplinary Sciences
Maartje van der Heijden, Daniel M. Miedema, Bartlomiej Waclaw, Veronique L. Veenstra, Maria C. Lecca, Lisanne E. Nijman, Erik van Dijk, Sanne M. van Neerven, Sophie C. Lodestijn, Kristiaan J. Lenos, Nina E. de Groot, Pramudita R. Prasetyanti, Andrea Arricibita Varea, Douglas J. Winton, Jan Paul Medema, Edward Morrissey, Bauke Ylstra, Martin A. Nowak, Maarten F. Bijlsma, Louis Vermeulen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Genetics & Heredity
Joseph Christopher, Ann-Sofie Thorsen, Sam Abujudeh, Filipe C. Lourenco, Richard Kemp, Paul K. Potter, Edward Morrissey, Lee Hazelwood, Douglas J. Winton
Article
Biochemical Research Methods
Kristiaan J. Lenos, Sophie C. Lodestijn, Scott K. Lyons, Maarten F. Bijlsma, Daniel M. Miedema, Louis Vermeulen
Article
Medicine, Research & Experimental
Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maartje C. S. van der Heijden, Lisanne E. Nijman, Maria C. Lecca, Pieter J. Tanis, Kristiaan J. Lenos, Louis Vermeulen
LABORATORY INVESTIGATION
(2020)
Article
Pathology
Krijn J. C. Haasnoot, Yara Backes, Leon M. G. Moons, Onno Kranenburg, Anne Trinh, Louis Vermeulen, Michael Noe, Jurriaan B. Tuynman, Anja U. G. van Lent, Rosaline van Ginneken, Cornelis A. Seldenrijk, Mihaela G. Raicu, Kari Trumpi, Inge Ubink, Anya N. Milne, Jurjen J. Boonstra, John N. Groen, Matthijs P. Schwartz, Frank H. J. Wolfhagen, Joost M. J. Geesing, Frank ter Borg, Lodewijk A. A. Brosens, Jeroen van Bergeijk, Bernhard W. M. Spanier, Wouter H. de Vos tot Nederveen Cappel, Koen Kessels, Tom C. J. Seerden, Frank P. Vleggaar, G. Johan A. Offerhaus, Peter D. Siersema, Sjoerd G. Elias, Miangela M. Lacle
Article
Cell Biology
Ann-Sofie Thorsen, Doran Khamis, Richard Kemp, Mathilde Colombe, Filipe C. Lourenco, Edward Morrissey, Douglas Winton
Summary: This study introduces a lineage-tracing approach based on Dre recombinase activation, independent of Cre, to investigate clonal biology of the intestinal epithelium. The research reveals that many new clones within tumors rapidly become extinct, while surviving clones exhibit accelerated population growth compared to normal crypts, showing heterogeneous dynamics within intra-tumor glands.
DISEASE MODELS & MECHANISMS
(2021)
Article
Oncology
Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Leveille, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
CANCER CELL INTERNATIONAL
(2020)
Editorial Material
Genetics & Heredity
Sanne Bootsma, Sanne M. van Neerven, Louis Vermeulen
Summary: Half of colorectal cancers have KRAS-activating mutations, which affect cancer cells' metabolic dependencies and lead to resistance to common drugs. A new study reveals the metabolic rewiring driven by KRAS and identifies a new therapeutic target for KRAS-mutant cancers.
Review
Oncology
Sanne ten Hoorn, Tim R. de Back, Dirkje W. Sommeijer, Louis Vermeulen
Summary: The CMS classification system has potential clinical value in predicting prognosis and treatment response in colorectal cancer (CRC) patients. In local disease, CMS4 tumors have worse overall survival, while in metastatic disease, CMS1 tumors consistently have worse survival. Adjuvant chemotherapy is most beneficial for CMS2 and CMS3 tumors in stage II and III CRC, while it is not effective in CMS4 tumors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Review
Oncology
Sophie C. Lodestijn, Sanne M. van Neerven, Louis Vermeulen, Maarten F. Bijlsma
Summary: Cell generation and renewal play essential roles in tissue development, maintenance, and regeneration. The pancreas is a dormant organ with limited regeneration capacity, and understanding the underlying mechanisms of pancreatic stem cells may provide insights into the role of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC). Imbalance between cellular proliferation and differentiation can lead to disease initiation, particularly cancer formation.
Article
Oncology
Nikhil Lal, Dedrick Kok Hong Chan, Minn E. Ng, Louis Vermeulen, Simon James Alexander Buczacki
Summary: High lymph node (LN) yield is predictive of overall and disease-free survival in non-metastatic colon cancer. There is no association between higher LN yield and increasing nodal positivity, but it is strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response, especially in node-negative cancers. These findings were validated in an independent dataset.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Analytical
Job Komen, Sanne M. van Neerven, Elsbeth G. B. M. Bossink, Nina E. de Groot, Lisanne E. Nijman, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer
Summary: The cancer xenograft model, commonly used for testing novel cancer drugs, has limitations including ethical concerns and imperfect efficacy predictions leading to high clinical attrition rates. Utilizing microfluidic cancer-on-chip models could potentially improve upon the xenograft model by reducing variation, increasing sensitivity, scalability, and incorporating human factors. These chip models were able to replicate key elements of the xenograft model and provide additional drug efficacy information.
