期刊
EMBO JOURNAL
卷 30, 期 24, 页码 4931-4941出版社
WILEY
DOI: 10.1038/emboj.2011.358
关键词
capsular polysaccharide; LytR-CpsA-Psr proteins; MreB; peptidoglycan; teichoic acids
资金
- UK Biotechnology and Biological Sciences Research Council
- BBSRC [BB/G015902/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G015902/1, 983409] Funding Source: researchfish
Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall. The EMBO Journal (2011) 30, 4931-4941. doi: 10.1038/emboj.2011.358; Published online 30 September 2011
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