Article
Microbiology
Aaron B. Benjamin, Madeleine G. Moule, Maruti K. Didwania, Jonathan Hardy, Panatda Saenkham-Huntsinger, Preeti Sule, Josefine Eilso Nielsen, Jennifer S. Lin, Christopher H. Contag, Annelise E. Barron, Jeffrey D. Cirillo
Summary: Staphylococcus aureus resistance is a major concern in healthcare, and antimicrobial peptoids show promise as an alternative to conventional antibiotics for treating S. aureus wound infections, with efficient killing of bacteria and prevention of biofilm formation and detachment.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Multidisciplinary
Adeline Espinasse, Manibarsha Goswami, Junshu Yang, Onanong Vorasin, Yinduo Ji, Erin E. Carlson
Summary: The emergence of drug-resistant bacteria has led to the need for novel approaches and targets to combat this challenge. Bacterial two-component systems (TCSs) are important in bacterial adaptive responses and are linked to antibiotic resistance and virulence. A study developed maleimide-based compounds and evaluated them against a model histidine kinase, resulting in the identification of a molecule that decreased the lesion size caused by methicillin-resistant S. aureus skin infection by 65% in a murine model.
Article
Biotechnology & Applied Microbiology
Yan Huang, Na Yang, Da Teng, Ruoyu Mao, Ya Hao, Xuanxuan Ma, Lingyun Wei, Jianhua Wang
Summary: In this study, three-dimensional reticulated antimicrobial peptide hydrogels were developed for preventing and treating Staphylococcus aureus infections. The HPC-NZ2114 hydrogel exhibited sustained release, good cytocompatibility, and excellent antibacterial activity both in vitro and in vivo. It accelerated wound healing by reducing inflammation and promoting angiogenesis.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Infectious Diseases
Jian Peng, Biswajit Mishra, Rajamohammed Khader, LewisOscar Felix, Eleftherios Mylonakis
Summary: In this study, a smaller antimicrobial peptide C18 derived from cecropin 4 showed high antibacterial activity against various bacteria and yeasts, with a remarkable effect on drug-resistant Staphylococcus aureus. C18 also exhibited the capability to eliminate persister cells, reduce biofilm adherence, interact with DNA, and down-regulate virulence factor genes. Moreover, C18 showed promising results in a Galleria mellonella model, highlighting its potential as a therapeutic candidate for severe MRSA infections.
Article
Microbiology
Masanori Matsumoto, Seitaro Nakagawa, Lingzhi Zhang, Yuumi Nakamura, Amer E. Villaruz, Michael Otto, Christiane Wolz, Naohiro Inohara, Gabriel Nunez
Summary: The growth and invasion of Staphylococcus aureus in the skin are differently regulated by Agr and PSM alpha, with Agr limiting intracellular killing within neutrophils to promote pathogen expansion in the dermis and subcutaneous tissue.
CELL HOST & MICROBE
(2021)
Review
Biochemistry & Molecular Biology
Isabella Hernandez-Aristizabal, Ivan Dario Ocampo-Ibanez
Summary: The emergence of bacteria resistant to conventional antibiotics, especially VRSA and VISA strains, poses a serious threat to global health. Developing new antimicrobial alternatives, such as antimicrobial peptides (AMPs), is urgently needed as a promising therapeutic strategy to combat resistant strains. Evaluating natural, artificial, and synthetic AMPs against VRSA and VISA strains shows great potential for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Nilton A. S. Neto, Jose T. A. Oliveira, Tawanny K. B. Aguiar, Leandro P. Bezerra, Levi A. C. Branco, Felipe P. Mesquita, Cleverson D. T. Freitas, Pedro F. N. Souza
Summary: This study investigated the antibiofilm activity of synthetic antimicrobial peptides (SAMPs) in combination with the antibiotic ciprofloxacin against Staphylococcus aureus. The results demonstrated that certain peptides in combination with ciprofloxacin effectively inhibited biofilm formation and degraded preformed biofilms. These active peptides formed pores in the bacterial cellular membrane, enhancing the antibacterial activity of ciprofloxacin.
Article
Infectious Diseases
Md Saruar Bhuiyan, Jhih-Hang Jiang, Xenia Kostoulias, Ravali Theegala, Graham J. Lieschke, Anton Y. Peleg
Summary: The study investigated host innate immune responses against clinically derived, daptomycin-resistant and -susceptible Staphylococcus aureus isolates using a zebrafish infection model. Results showed that control of daptomycin-resistant S. aureus infections in vivo was compromised due to cross-resistance to host cationic antimicrobial peptides, shedding light on persistent infections caused by this troublesome pathogen.
Article
Microbiology
Bingqian Yuan, Xiaoyu Lu, Min Yang, Qiyi He, Zhuocen Cha, Yaqun Fang, Yan Yang, Lei Xu, Jingting Yan, Ren Lai, Aili Wang, Xiaodong Yu, Zilei Duan
Summary: Staphylococcus aureus (S. aureus) is a common pathogenic bacterium with increasing drug resistance. The antimicrobial peptide GW18 shows excellent activity against various strains of S. aureus and significantly reduces infection in animal models.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Narchonai Ganesan, Biswajit Mishra, LewisOscar Felix, Eleftherios Mylonakis
Summary: Clinical management of Staphylococcus aureus infections is challenging due to high incidence, virulence, and drug resistance. The treatment of drug-resistant strains, such as MRSA, is further complicated by tolerance and persistence to antimicrobial agents. Membrane disruptors, such as antimicrobial peptides and small molecules, have the potential to overcome these challenges by targeting the bacterial membrane and secondary mechanisms.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Review
Microbiology
Jiangbi Li, Qiangqiang Wen, Feng Gu, Lijuan An, Tiecheng Yu
Summary: Staphylococcus aureus infections are challenging to cure completely due to the bacteria's ability to internalize into cells, leading to recurrent infections. Different phases of internalization require different treatments, such as cell wall-anchored protein vaccines and microbial agents for preventing adhesion, and nanoparticles and bacteriophage therapy for eliminating bacteria. Researchers are focusing on preventing and treating S. aureus internalization to reduce treatment costs and improve outcomes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sergey V. Kravchenko, Pavel A. Domnin, Sergei Y. Grishin, Alexander V. Panfilov, Viacheslav N. Azev, Leila G. Mustaeva, Elena Y. Gorbunova, Margarita I. Kobyakova, Alexey K. Surin, Anna V. Glyakina, Roman S. Fadeev, Svetlana A. Ermolaeva, Oxana V. Galzitskaya
Summary: The need to develop new antimicrobial peptides is essential due to the high resistance of pathogenic bacteria to traditional antibiotics. This study successfully creates hybrid antimicrobial peptides containing amyloidogenic regions of the ribosomal S1 protein, showing significant antimicrobial effects against both Gram-positive and Gram-negative bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Christoph J. Slavetinsky, Janna N. Hauser, Cordula Gekeler, Jessica Slavetinsky, Andre Geyer, Alexandra Kraus, Doris Heilingbrunner, Samuel Wagner, Michael Tesar, Bernhard Krismer, Sebastian Kuhn, Christoph M. Ernst, Andreas Peschel
Summary: The pandemic of antibiotic resistance is a major threat to human health, and new antimicrobial strategies are needed. Multiple peptide resistance factor (MprF) is a key factor that increases the resistance of methicillin-resistant Staphylococcus aureus (MRSA) and other pathogens to host defense peptides and antibiotics. In this study, monoclonal antibodies targeting MprF were developed, and an antibody called M-C7.1 was found to sensitize MRSA to antimicrobial peptides and antibiotics, as well as impair its survival in human phagocytes. These findings suggest that MprF inhibitors could be used as a new antivirulence approach against MRSA and other bacterial pathogens.
Article
Microbiology
Junho Cho, Stephen K. Costa, Rachel M. Wierzbicki, William F. C. Rigby, Ambrose L. Cheung
Summary: Staphylococcus aureus has developed survival strategies to respond to host defense proteins by utilizing a two-component system and an efflux pump, where the lysine-rich extracellular loop of VraG interferes with GraS sensing and signaling. This finding highlights an interesting facet of how efflux pumps disrupt host defense protein signaling in bacterial pathogens.
Article
Microbiology
David W. Watson, Santiago L. Iglesias, Edward M. Vasarhelyi, David E. Heinrichs
Summary: This study demonstrates that synovial fluid from osteoarthritic patients restricts S. aureus growth and is bactericidal for certain strains. Antibiotic-resistant strains present challenges in treatment options. By targeting the GraXRS-VraFG regulatory system and mprF, future therapeutics for S. aureus bone and joint infections may be developed.
Article
Microbiology
Tamiko Oguri, Won-Sik Yeo, Taeok Bae, Hyunwoo Lee
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Multidisciplinary Sciences
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-Sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
NATURE COMMUNICATIONS
(2016)
Review
Genetics & Heredity
Qian Liu, Won-Sik Yeo, Taeok Bae
Article
Chemistry, Multidisciplinary
Weizhong Chen, Yifei Zhang, Won-Sik Yeo, Taeok Bae, Quanjiang Ji
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Retraction
Multidisciplinary Sciences
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Qian Liu, Mo Hu, Won-Sik Yeo, Lei He, Tianming Li, Yuanjun Zhu, Hongwei Meng, Yanan Wang, Hyunwoo Lee, Xiaoyun Liu, Min Li, Taeok Bae
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Qian Liu, Xing Wang, Juanxiu Qin, Sen Cheng, Won-Sik Yeo, Lei He, Xiaowei Ma, Xiaoyun Liu, Min Li, Taeok Bae
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Won-Sik Yeo, Rekha Arya, Kyeong Kyu Kim, Hyunyoung Jeong, Kyu Hong Cho, Taeok Bae
SCIENTIFIC REPORTS
(2018)
Article
Food Science & Technology
Arundhathi Venkatasubramaniam, Tulasikumari Kanipakala, Nader Ganjbaksh, Rana Mehr, Ipsita Mukherjee, Subramaniam Krishnan, Taeok Bae, M. Javad Aman, Rajan P. Adhikari
Article
Chemistry, Medicinal
Pushpak Mizar, Rekha Arya, Truc Kim, Soyoung Cha, Kyoung-Seok Ryu, Won-sik Yeo, Taeok Bae, Wook Kim, Ki Hun Park, Kyeong Kyu Kim, Seung Seo Lee
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Microbiology
Sojeong Heo, Taeok Bae, Jong-Hoon Lee, Do-Won Jeong
FEMS MICROBIOLOGY LETTERS
(2019)
Article
Microbiology
Thanh Nguyen, Truc Kim, Hai Minh Ta, Won Sik Yeo, Jongkeun Choi, Pushpak Mizar, Seung Seo Lee, Taeok Bae, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
Article
Immunology
ByungHyun Kim, TingTing Jiang, Jun-Hyun Bae, Hye Su Yun, Seong Han Jang, Jung Hyun Kim, Jae Deog Kim, Jin-Hoe Hur, Kensuke Shibata, Kenji Kurokawa, Yunjin Jung, Andreas Peschel, Taeok Bae, Bok Luel Lee
INFECTION AND IMMUNITY
(2019)
Article
Microbiology
Won-Sik Yeo, Chiamara Anokwute, Philip Marcadis, Marcus Levitan, Mahmoud Ahmed, Yeun Bae, Kyeongkyu Kim, Tatiana Kostrominova, Qian Liu, Taeok Bae
JOURNAL OF BACTERIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nana Yang, Qiao Cao, Shuyang Hu, Chenchen Xu, Ke Fan, Feifei Chen, Cai-Guang Yang, Haihua Liang, Min Wu, Taeok Bae, Lefu Lan
MOLECULAR MICROBIOLOGY
(2020)