Article
Medicine, Research & Experimental
Ozlem Mutlu-Burnaz, Burak Yulug, Merve Oncul, Esref Celik, Nilufer Sayar Atasoy, Seyda Cankaya, Lutfu Hanoglu, Halil Aziz Velioglu
Summary: Memory storage in the brain is a key subject in neuroscience, with particular interest in the role of hypothalamic melanin-concentrating hormone (MCH) neuronal activity in memory consolidation. In this study, chemogenetic inhibition of MCH neurons did not show significant improvement or worsening in memory consolidation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O'Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Poehnl, Monty G. Mythen, Michael P. W. Grocott, Denny Z. H. Levett, Daniel S. Martin, Martin Feelisch, Xtreme Alps Res Grp
Summary: This study investigated the effects of nitrate supplementation on exercise physiology during high altitude exposure. The results showed that exercise at high altitude reduced nitrate and nitrite levels in the blood, but nitrate supplementation reversed this phenomenon. However, it did not improve exercise efficiency. Interestingly, nitrate supplementation also decreased V?O(2)peak.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Christopher L. Chapman, Zachary J. Schlader, Emma L. Reed, Morgan L. Worley, Blair D. Johnson
Summary: The study results suggest that acute consumption of beetroot juice does not attenuate reductions in renal perfusion during acute mild hypercapnia in healthy young adults.
Article
Biochemistry & Molecular Biology
Alice Ossoli, Ilenia Minicocci, Marta Turri, Alessia Di Costanzo, Laura D'Erasmo, Simone Bini, Linda Montavoci, Fabrizio Veglia, Laura Calabresi, Marcello Arca
Summary: Individuals with loss-of-function mutations in the ANGPTL3 gene express a rare lipid phenotype called Familial Combined Hypolipidemia (FHBL2). FHBL2 individuals show reduced plasma concentrations of total cholesterol and triglycerides as well as of lipoprotein particles, including HDL. ANGPTL3 acts as a circulating inhibitor of LPL and EL and it is thought that EL hyperactivity is the cause of plasma HDL reduction in FHBL2. HDL isolated from homozygous and heterozygous FHBL2 individuals were evaluated for their ability to preserve endothelial homeostasis as compared to control HDL. It was found that changes in HDL composition associated with the partial or complete absence of ANGPTL3 did not alter some of the potentially anti-atherogenic functions of these lipoproteins.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Physiology
Jacqueline K. Limberg, Sarah E. Baker, Elizabeth P. Ott, Dain W. Jacob, Zachariah M. Scruggs, Jennifer L. Harper, Camila M. Manrique-Acevedo
Summary: This study found that even with the use of ET receptor antagonists, the sympathetic nerve activity and blood pressure response of men cannot be reduced when exposed to low oxygen conditions.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Andrew R. Brotto, Rhys Beaudry, Samira Rowland, Sean van Diepen, Michael K. Stickland
Summary: This study aimed to investigate whether a D-L,D-NO manoeuvre alters pulmonary perfusion pressure. The results suggest that a single D-L,D-NO manoeuvre does not change pulmonary artery systolic pressure (PASP) and therefore would not acutely impact pulmonary capillary blood volume or membrane diffusing capacity.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Neurosciences
Faith C. C. Adams, Jacob W. W. Pickersgill, Claudia V. V. Turco, Stevie D. D. Foglia, Stephen L. L. Toepp, Ravjot R. R. Rehsi, Karishma R. R. Ramdeo, Maria Salman, Aimee J. J. Nelson
Summary: Sensorimotor integration refers to combining sensory information with motor commands. This study aimed to investigate the influence of tactile discrimination training on neurophysiological measures of sensorimotor integration. The findings suggest that 30 minutes of maze training is insufficient to modify SAI and LAI.
Article
Multidisciplinary Sciences
David J. Braun, Hilaree N. Frazier, Verda A. Davis, Meggie J. Coleman, Colin B. Rogers, Linda J. Van Eldik
Summary: In this study, the early-stage pathological changes in an Alzheimer's disease (AD) model were evaluated by deleting microglial p38α. The results showed that the loss of microglial p38α did not alter behavioral outcomes, proinflammatory cytokine levels, or overall amyloid plaque burden. However, it did increase hippocampal levels of soluble Aβ42 and reduce colocalization of Iba1 and 6E10 in microglia in close proximity to plaques.
Article
Cardiac & Cardiovascular Systems
Henrike Arfsten, Georg Goliasch, Philipp E. Bartko, Suriya Prausmueller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Huelsmann, Noemi Pavo
Summary: The study aimed to investigate the response of two substrates of NEP, PENK and pro-SP, to ARNi therapy in patients with HFrEF. The results showed a slight increase in circulating PENK concentrations after 1 and 2 years of follow-up, but no significant change in pro-SP levels during the entire follow-up period.
Review
Endocrinology & Metabolism
Rumyana Dimova, Tsvetalina Tankova
Summary: SGLT2 inhibitors increase renal glucose excretion, decrease blood glucose levels, and may play a role in cardiovascular protection for patients with type 2 diabetes by inhibiting sympathetic nerve tone.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nicholas Stafford, Min Zi, Florence Baudoin, Tamer M. A. Mohamed, Sukhpal Prehar, Daria De Giorgio, Elizabeth J. Cartwright, Roberto Latini, Ludwig Neyses, Delvac Oceandy
Summary: This study demonstrates that inhibition of PMCA4 does not impact chronic outcomes following myocardial infarction.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Micaela L. O'Reilly, Eugene Mironets, Tatiana M. Shapiro, Kallon Crowther, Eileen Collyer, John R. Bethea, Veronica J. Tom
Summary: After a severe spinal cord injury, heightened spinal sympathetic reflex activity can lead to autonomic dysreflexia, a life-threatening condition characterized by sudden hypertension. Targeting central sTNF alpha signaling within 2 weeks post-injury is necessary to decrease sympathetic hyperreflexia according to research findings.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Developmental Biology
Carol A. Dannenhoffer, David F. Werner, Elena I. Varlinskaya, Linda P. Spear
Summary: The study found that AIE exposure did not affect the retention of adolescent-like sensitivity to NR2B receptor antagonism, as well as the social and aversive effects of ifenprodil in adult rats. Additionally, AIE did not induce a shift in vGlut2 to vGAT ratios in the brains of adult rats.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Neurosciences
Praachi Tiwari, Darshana Kapri, Amartya Pradhan, Angarika Balakrishnan, Pratik R. Chaudhari, Vidita A. Vaidya
Summary: This study investigates the impact of enhanced G(i) signaling during postnatal and juvenile periods on adult anxiety and depression behaviors. The results indicate that inhibiting CaMKII alpha-positive forebrain excitatory neurons during these developmental windows does not affect the programming of anxiodepressive behaviors in adulthood.
Article
Behavioral Sciences
Laurine Boch, Thomas Morvan, Thibaut Neige, Nino Kobakhidze, Elodie Panzer, Brigitte Cosquer, Anne Pereira de Vasconcelos, Aline Stephan, Jean- Christophe Cassel
Summary: This study investigated the function of the thalamic reuniens nucleus (Re) in encoding, holding, and retrieval phases of spatial working memory (SWM). The results did not support the involvement of Re in SWM. Previous studies mainly used T-maze alternation tasks, and it is important to determine if Re is required in tasks with short information-holding delays.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Physiology
Nicholas G. Jendzjowsky, Darren S. DeLorey
JOURNAL OF APPLIED PHYSIOLOGY
(2013)
Article
Physiology
Nicholas G. Jendzjowsky, Darren S. DeLorey
JOURNAL OF APPLIED PHYSIOLOGY
(2013)
Article
Neurosciences
Nicholas G. Jendzjowsky, Timothy P. Just, Darren S. DeLorey
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Multidisciplinary Sciences
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson
NATURE COMMUNICATIONS
(2018)
Review
Critical Care Medicine
Nicholas G. Jendzjowsky, Margaret M. Kelly
Editorial Material
Neurosciences
Kim Barrett, Beth Habecker
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Multidisciplinary Sciences
Erik van Tilburg Bernardes, Veronika Kucharova Pettersen, Mackenzie W. Gutierrez, Isabelle Laforest-Lapointe, Nicholas G. Jendzjowsky, Jean-Baptiste Cavin, Fernando A. Vicentini, Catherine M. Keenan, Hena R. Ramay, Jumana Samara, Wallace K. MacNaughton, Richard J. A. Wilson, Margaret M. Kelly, Kathy D. McCoy, Keith A. Sharkey, Marie-Claire Arrieta
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Nicholas G. Jendzjowsky, Arijit Roy, Mircea Iftinca, Nicole O. Barioni, Margaret M. Kelly, Brittney A. Herrington, Frank Visser, Christophe Altier, Richard J. A. Wilson
Summary: The carotid bodies can be stimulated by asthma-associated Th2 cytokines, leading to sensory nerve excitation and asthmatic bronchoconstriction. Inhibiting the PKC ε-TRPV1 signaling pathway may alleviate respiratory distress and airway hyperresponsiveness in asthmatic patients.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Respiratory System
Nicholas Jendzjowsky, Austin Laing, Michelle Malig, John Matyas, Elaine de Heuvel, Curtis Dumonceaux, Elaine Dumoulin, Alain Tremblay, Richard Leigh, Alex Chee, Margaret M. Kelly
Summary: Bronchial thermoplasty primarily affects airway smooth muscle and nerves, with effects still present at 12 months post-treatment.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Nicholas G. Jendzjowsky, Arijit Roy, Richard J. A. Wilson
Summary: Carotid bodies are multimodal sensors that regulate autonomic reflexes and are also involved in immune reflex regulation. Studies on asthma models suggest that carotid bodies mediate asthmatic bronchoconstriction through the LPA-LPAr-PKCε-TRPV1 pathway. Allergen sensitization can enhance the acute sensitivity of carotid bodies to LPA, possibly involving increased expression of LPAr. This allergen-induced sensitization of carotid bodies highlights their potential role in asthma, along with blood-borne inflammatory mediators.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Jekaterina Zyuzin, Nicholas Jendzjowsky
Summary: Sensory convergence of pulmonary vagal nociceptors and carotid chemoreceptors occurs in the nucleus tractus solitarius and nucleus ambiguus, leading to enhanced motor output for airway defense.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicolas Millet, Norma Solis, Diane Aguilar, Michail S. Lionakis, Robert T. Wheeler, Nicholas Jendzjowsky, Marc Swidergall
Summary: This study reveals the role of the beta-glucan receptor EphA2 in modulating renal immunopathology during disseminated candidiasis through IL-23 signaling and ferroptotic cell death.
NATURE COMMUNICATIONS
(2022)
Article
Respiratory System
Jordan D. Bird, Scott A. Sands, Raichel M. Alex, Conan L. H. Shing, Brooke M. Shafer, Nicholas G. Jendzjowsky, Richard J. A. Wilson, Trevor A. Day, Glen E. Foster
Summary: This study aimed to assess the effects of biological sex on loop gain and central sleep apnea (CSA) severity during acclimatization to high altitude. The results showed that CSA severity worsened with acclimatization in men but not in women, which may be due to greater increases in loop gain in men.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Physiology
Nicholas G. Jendzjowsky, Timothy P. Just, Kelvin E. Jones, Darren S. DeLorey
PHYSIOLOGICAL REPORTS
(2014)