Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yi-Long Huang, Chao-Hsiung Lin, Tsung-Hsien Tsai, Chen-Hua Huang, Jie-Ling Li, Liang-Kung Chen, Chun-Hsien Li, Ting-Fen Tsai, Pei-Ning Wang
Summary: This study utilized untargeted metabolomics analysis to characterize plasma metabolites in MCI patients progressing to AD and stable MCI patients. A 20-metabolite signature panel associated with the presence and progression of AD was identified using machine learning, offering predictive value for conversion from MCI to AD. Additionally, the bacteria-generated metabolite indole-3-propionic acid was identified as a predictor of AD progression, suggesting a role for gut microbiota in AD pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Meysam Amidfar, Gholamreza Askari, Yong-Ku Kim
Summary: The discovery of biomarkers and the application of metabolomics can be useful for diagnosing and treating Alzheimer's disease and mild cognitive impairment, while investigating the relationship between nutritional behavior and Alzheimer's disease can provide preventive strategies against cognitive decline and dementia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Computer Science, Artificial Intelligence
Sunghong Park, Chang Hyung Hong, Dong-gi Lee, Kanghee Park, Hyunjung Shin
Summary: With the rapid aging of the population, Alzheimer's disease (AD) is becoming a serious problem, and early detection of the disease is crucial. By learning brain atrophy patterns, machine learning algorithms can predict the conversion from mild cognitive impairment (MCI) to AD. However, it is challenging to distinguish between the conversion group and the non-conversion group due to small differences and large within-group variability in brain images. To address this issue, a method called prospective classification, which projects brain images into the future for classification, is proposed.
Article
Biochemistry & Molecular Biology
Bruna De Felice, Cinzia Coppola, Simona Bonavita, Elisabetta Signoriello, Concetta Montanino, Federica Farinella, Carmela Matrone
Summary: Mild cognitive impairment (MCI) is a transitional stage before dementia with a high risk of progression to Alzheimer's disease. Non-coding RNAs, including long non-coding RNAs (lncRNAs), play a crucial role in gene expression regulation and can improve understanding of the genetic factors and pathophysiology of MCI. This study identified the expression patterns and relevant lncRNA-associated miRNA regulatory axes in the blood of MCI patients, proposing RNA targets involved in the pathogenesis of MCI.
Review
Food Science & Technology
Guangsu Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: Analysis of randomized controlled trials suggests that dietary supplementation with probiotics may improve cognitive function, particularly in individuals with mild cognitive impairment.
Article
Clinical Neurology
Egle Audronyte, Vaiva Sutnikiene, Gyte Pakulaite-Kazliene, Gintaras Kaubrys
Summary: This study investigated olfactory memory and its relationship with verbal memory and other clinical features in patients with early-stage Alzheimer's disease (AD). The results showed that olfactory memory was significantly impaired in patients with AD compared to individuals with mild cognitive impairment due to AD and cognitively normal older participants. Furthermore, the duration of AD symptoms was a strong predictor of olfactory recognition memory scores.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Mingrui Liu, Baohu Liu, Zelin Ye, Dongyu Wu
Summary: This study used a bibliometric approach to analyze the application of electroencephalogram (EEG) in mild cognitive impairment (MCI) from 2005 to 2022. The research emphasis has shifted from examining local brain lesions with EEG to neural network mechanisms. The use of big data and intelligent analysis methods in EEG research is becoming more important, and linking MCI to other neurological disorders and evaluating new targets for diagnosis and treatment has become a new research trend.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nuria Estanyol-Torres, Cristina Domenech-Coca, Raul Gonzalez-Dominguez, Antonio Minarro, Ferran Reverter, Jose Antonio Moreno-Munoz, Jesus Jimenez, Manel Martin-Palomas, Pol Castellano-Escuder, Hamza Mostafa, Santi Garcia-Vallve, Nerea Abasolo, Miguel A. Rodriguez, Helena Torrell, Josep M. del Bas, Alex Sanchez-Pla, Antoni Caimari, Anna Mas-Capdevila, Cristina Andres-Lacueva, Anna Crescenti
Summary: The study aimed to evaluate the effects of a mixture of four dietary fibers on obese rats. The results showed that the fiber mixture significantly reduced body weight, adiposity, HbA1c, and HDL-cholesterol levels in the rats. It also improved energy expenditure, fat oxidation, and intestinal health, while reducing adiponectin and LPS levels. The intervention effect was observed at the metabolomic, metagenomic, and transcriptomic levels.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Hamza Mostafa, Inken Behrendt, Tomas Merono, Raul Gonzalez-Dominguez, Mathias Fasshauer, Silvia Rudloff, Cristina Andres-Lacueva, Sabine Kuntz
Summary: This study aimed to investigate whether plasma-isolated anthocyanins and their metabolites (PAMs) modulate pancreatic cancer cell migration and to identify molecular targets of PAMs in this process. A 28-day intervention trial involving 35 healthy subjects was conducted to compare the effects of daily anthocyanin-rich juice intake versus placebo. Plasma extracts were used for migration and mechanistic in vitro studies as well as metabolomic analysis. The intake of anthocyanin-rich juice significantly reduced PANC-1 migration, and also decreased the expression of adhesion molecules in PANC-1 and endothelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Gonzalez-Dominguez, Jesus Dominguez-Riscart, Maria Millan-Martinez, Rosa Maria Mateos-Bernal, Alfonso Maria Lechuga-Sancho, Raul Gonzalez-Dominguez
Summary: Although puberty influences obesity progression, the molecular mechanisms underlying the role of sexual maturation in obesity-related complications are largely unknown. This study investigates the impact of puberty on oxidative stress, inflammation, and trace element blood levels in children with obesity. The findings suggest that pubertal development improves inflammatory and oxidative control in obese children, possibly through trace element-mediated buffering mechanisms.
Article
Biochemistry & Molecular Biology
Alvaro Gonzalez-Dominguez, Jesus Dominguez-Riscart, Maria Millan-Martinez, Alfonso Maria Lechuga-Sancho, Raul Gonzalez-Dominguez
Summary: Although the role of perturbed metal homeostasis in childhood obesity is well established, the association has rarely been investigated in terms of sexual dimorphism. This study examined children with obesity, with and without insulin resistance, and healthy control children, using multi-elemental analysis and measured various variables related to metabolism and hormones. The results showed that children with obesity, regardless of sex and insulin resistance status, had increased plasma copper-to-zinc ratios. However, obese girls showed increased contents of iron, zinc, and copper, suggesting a sex-dependent dysregulation in response to inflammatory processes and hyperinsulinemia.
Article
Biochemical Research Methods
Miguel Fernandez-Garcia, Ines Mesquita, Carolina Ferreira, Marta Araujo, Bhaskar Saha, Ma Fernanda Rey-Stolle, Antonia Garcia, Ricardo Silvestre, Coral Barbas
Summary: In this study, a multiplatform metabolomics pipeline was used to analyze the metabolome alterations induced in L. donovani-infected human monocyte-derived macrophages at different time points post-infection. The results showed that citrulline, arginine, and glutamine exhibited constant trends across all time points, while most metabolite alterations underwent partial recovery during amastigote maturation. Additionally, an early induction of sphingomyelinase and phospholipase activities, as well as amino acid depletion, was correlated with a major metabolite response. This study provides a comprehensive overview of the metabolome alterations occurring during promastigote-to-amastigote differentiation and maturation of L. donovani inside macrophages, contributing to our understanding of the relationship between L. donovani pathogenesis and metabolic dysregulation.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Chemistry, Analytical
Maricruz Mamani-Huanca, Alma Villasenor, Carolina Gonzalez-Riano, Angeles Lopez-Lopez, Angeles Lopez-Gonzalvez, Coral Barbas
Summary: Metabolites, as the final products of metabolism, directly impact phenotype and constitute an organism's metabolome. Due to the diverse physicochemical properties of metabolites, analyzing them presents a significant challenge. Mass spectrometry-based techniques, such as capillary electrophoresis coupled to MS, have been widely used for metabolite analysis. This review highlights the role of CE-MS in untargeted metabolomics and compares it to HILIC separation mode. It also discusses the workflow, annotation tools, and future perspectives of CE-MS in studying human diseases.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Microbiology
Marta Ballesteros-Gutierrez, Marta Albareda, Coral Barbas, Angeles Lopez-Gonzalvez, Michael F. Dunn, Jose M. Palacios
Summary: Rhizobium leguminosarum bv. viciae (Rlv) UPM791 effectively nodulates pea and lentil, and a host-dependent protein called C189 was identified to have diaminobutyrate-2-oxoglutarate aminotransferase (DABA-AT) activity. The dat gene was found to be strongly induced in pea nodules, but not in lentil. Mutants defective in dat showed impaired symbiotic performance with pea plants, while no significant differences were observed in symbiosis with lentil. Comparative metabolomic analysis revealed differences in pea bacteroids, but not in lentil. The presence of L-homoserine and the absence of 2,4-diaminobutyrate (DABA) in pea nodules indicate that the Dat enzyme is involved in the adaptation mechanism of Rlv UPM791 to a homoserine-rich environment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paula Cuevas-Delgado, Veronica Miguel, Francisco J. Ruperez, Santiago Lamas, Coral Barbas
Summary: Chronic kidney disease (CKD) is characterized by progressive and irreversible deterioration of kidney function and structure. The study investigated the renal metabolome in a mouse model with enhanced fatty acid oxidation (FAO) subjected to folic acid nephropathy (FAN) using a multiplatform untargeted metabolomics approach. The results identified significant metabolic changes associated with fibrosis and highlighted the importance of studying the relationship between metabolism and fibrosis in CKD progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Miguel Fernandez-Garcia, Manuel Ares-Arroyo, Emilia Wedel, Natalia Montero, Coral Barbas, Ma Fernanda Rey-Stolle, Bruno Gonzalez-Zorn, Antonia Garcia
Summary: This study characterized the endometabolome of H. influenzae Rd KW20 using a multiplatform MS-based metabolomics approach, revealing that current H. influenzae GEMs only capture 15-20% of the endometabolome and showing the interconnection of polar metabolite pools. Additionally, 18 metabolites, including the antimicrobial metabolite cyclo(Leu-Pro), not previously included in H. influenzae GEMs were identified. The study also comprehensively characterized and quantitatively analyzed the phospholipidome of H. influenzae, providing insights into the fatty acyl chain composition and the probability distribution of phospholipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Alba Tor-Roca, Alex Sanchez-Pla, Aniko Korosi, Merce Pallas, Paul J. Lucassen, Pol Castellano-Escuder, Ludwig Aigner, Raul Gonzalez-Dominguez, Claudine Manach, Francisco Carmona, Esteban Vegas, Catherine Helmer, Catherine Feart, Sophie Lefevre-Arbogast, Jeanne Neuffer, Hyunah Lee, Sandrine Thuret, Cristina Andres-Lacueva, Cecilia Samieri, Mireia Urpi-Sarda
Summary: This study found that greater adherence to the Mediterranean diet is associated with lower odds of cognitive decline in older adults.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alvaro Gonzalez-Dominguez, Thalia Belmonte, Raul Gonzalez-Dominguez
Summary: The incidence of childhood obesity and metabolic syndrome has become a major public health concern in developed countries. Oxidative stress, along with inflammation, insulin disturbances, and dyslipidemia, plays a crucial role in the development of obesity-related complications. Understanding the molecular basis of oxidative dysregulations and the involvement of miRNAs can lead to new approaches for the diagnosis, prevention, and treatment of childhood obesity and associated disorders. This literature review focuses on the association between childhood obesity, metabolic syndrome, and miRNAs, with particular emphasis on the role of miRNAs in modulating obesity-related pathogenic events, especially oxidative stress.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Chemistry, Analytical
Sandra M. Camunas-Alberca, Maria Moran-Garrido, Jorge Saiz, Alma Villasenor, Ameer Y. Taha, Coral Barbas
Summary: Oxylipins are bioactive lipid mediators that play important roles in various processes. However, their potential as biomarkers in clinical settings is hindered by analytical challenges and variability in sample selection, collection, storage, and preparation. This review addresses these issues and illustrates their application in recent clinical studies. Harmonized protocols are needed to achieve reliable and reproducible results for their diagnostic and prognostic potential.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Sonia Dominguez-Zorita, Ines Romero-Carraminana, Fulvio Santacatterina, Pau B. B. Esparza-Molto, Carolina Simo, Araceli del-Arco, Cristina Nunez de Arenas, Jorge Saiz, Coral Barbas, Jose M. Cuezva
Summary: ATPase Inhibitory Factor 1 (IF1) regulates mitochondrial ATP synthase activity and its expression is variable in differentiated human and mouse cells. Overexpression of IF1 protects intestinal cells against colon inflammation. A conditional IF1-knockout mouse model was developed to investigate the role of IF1 in mitochondrial function and tissue homeostasis. Results showed that lack of IF1 led to increased ATP synthase/hydrolase activities, mitochondrial dysfunction, and a pro-inflammatory phenotype in mice.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Blanca Soler Palacios, Ricardo Villares, Pilar Lucas, Jose Miguel Rodriguez-Frade, Ana Cayuela, Jonathan G. Piccirillo, Manuel Lombardia, David Delgado Gestoso, Miguel Fernandez-Garcia, Cristina Risco, Coral Barbas, Fernando Corrales, Carlos Oscar S. Sorzano, Nuria Martinez-Martin, Jose Javier Conesa, Francisco J. Iborra, Mario Mellado
Summary: This study found that growth hormone can alter the metabolism of inflammatory macrophages, increase mitochondrial volume and alter mitochondrial dynamics. It reduces glycolysis and lactate production, and increases the density of the inner mitochondrial membrane. The results suggest that targeting macrophage metabolism could be a new approach for intervening in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Gonzalez-Dominguez, Raul Gonzalez-Dominguez
Summary: This review article discusses the challenges of identifying reliable biomarkers in metabolomics and examines the role of inter-individual variability in this process. Additionally, future perspectives for the applicability of metabolomics in biomedical research and clinical practice are provided.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
