Article
Chemistry, Analytical
Qiang Zhao, Yunjiao Wang, Bangyong Sun, Deqiang Wang, Gang Li
Summary: This research presents a dielectrophoretic manipulation technique based on nanogap electrodes, which allows for the capture, enrichment, and sorting of nanometer-sized objects in liquids. The technique shows potential applications in micro/nanofluidics and provides an alternative method for the non-invasive manipulation and characterization of nanoparticles such as DNA, proteins, and viruses.
Review
Chemistry, Multidisciplinary
Chao Pang, Basu R. Aryal, Dulashani R. Ranasinghe, Tyler R. Westover, Asami E. F. Ehlert, John N. Harb, Robert C. Davis, Adam T. Woolley
Summary: Bottom-up fabrication using DNA is a promising approach for the creation of nanoarchitectures, allowing for precise and programmable positioning of nanomaterials with specific functions. This method has significant potential in various domains such as sensing, drug delivery, and electronic device manufacturing.
Article
Chemistry, Physical
Alicia Moya, Jose Aleman, Julio Gomez-Herrero, Ruben Mas-Balleste, Pedro J. de Pablo
Summary: The tribological properties of oxidized multi-walled carbon nanotubes (ox-MWCNTs) and their hybridization with covalent organic framework (ox-MWCNTs@COF) on a mica surface were investigated. The lateral force needed to manipulate each carbon nanotube variant was found to change significantly, indicating increased adhesion of ox-MWCNTs@COF compared to ox-MWCNTs. Furthermore, electrical transport measurements revealed rectifying behavior and high resistivity in ox-MWCNTs@COF, in contrast to the near ohmic performance of ox-MWCNTs.
Article
Nanoscience & Nanotechnology
Petteri Piskunen, Boxuan Shen, Adrian Keller, J. Jussi Toppari, Mauri A. Kostiainen, Veikko Linko
Summary: The BLIN method enables large-scale versatile substrate patterning of metallic and semiconducting nanoshapes with various aspect ratios using biotemplated lithography of inorganic nanostructures. It shows successful feasibility and high-throughput fabrication of plasmonic, semiconducting, and metallic nanoparticles on substrates, ranging from 10 to 20 nm feature sizes to micrometer-long nanowires. This technology could potentially provide a cost-efficient pathway for mass producing versatile nanopatterned surfaces with smaller feature sizes for applications in plasmonics, biosensing, and functional metamaterials.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Marius Andrei Olariu, Catalin Tucureanu, Tudor Alexandru Filip, Iuliana Caras, Aurora Salageanu, Valentin Vasile, Marioara Avram, Bianca Tincu, Ina Turcan
Summary: This study proposes a feasible approach for the rapid, sensitive, and label-free identification of cancerous cells based on dielectrophoretic manipulation and electrical characterization. The method demonstrates the ability to electrically differentiate cancer cells from healthy cells based on impedance spectra.
Review
Chemistry, Multidisciplinary
Nishant Singh Jamwal, Amirkianoosh Kiani
Summary: This paper reviews the synthesis techniques, properties, and applications of gallium oxide, focusing on the polymorphs of Ga2O3 and their transformation to beta-Ga2O3. Various processes for synthesizing thin films, nanostructures, and bulk gallium oxide are examined, along with the electrical and optical properties of beta-gallium oxide. Discussions are also provided on the current and potential future applications of beta-Ga2O3 nanostructures.
Article
Materials Science, Multidisciplinary
Lei Wu, Pei Zhang, Chengqiang Feng, Jian Gao, Bingjun Yu, Linmao Qian
Summary: A fast and anisotropic etching method using HF/HNO3 mixtures was proposed to prepare nanostructures by friction-induced hillock formation and subsequent etching, with optimized fabrication parameters. Lowering the average dangling bond density delayed the breakup of Si-H bonds and Si-Si backbonds, leading to defect-free nanostructures fabricated by anisotropic etching.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Tripti Gupta, R. P. Chauhan
Summary: Synthesizing semiconductors at the nano level, particularly ZnSe, using solvothermal technique combined with subsequent calcination process, results in samples with varied crystallite sizes and morphologies. The choice of Zn precursors significantly impacts the characteristics of the ZnSe samples, including their particle size, morphologies, and electrical properties.
SURFACES AND INTERFACES
(2021)
Review
Biochemical Research Methods
Benjamin Sarno, Daniel Heineck, Michael J. Heller, Stuart D. Ibsen
Summary: The 20th century saw significant advancements in dielectrophoresis (DEP) technologies, with a focus on biological and clinical applications. The next decade is likely to see an increase in DEP-related patent applications and continued progress in biological and medical-focused applications, as well as applications in microfabrication. DEP offers unique capabilities to manipulate small particles in precise ways that enable scientific inquiry beyond conventional methods.
Article
Engineering, Electrical & Electronic
Anushree Jogi, A. Ayana, B. V. Rajendra
Summary: Nanostructured Zn1-xMgxO (x = 0-0.04) thin films were prepared on a glass substrate using sol-gel dip coating. The films exhibited a hexagonal wurtzite structure with decreasing diffraction peak intensity and changing crystallite size as Mg doping concentration increased. Optical analysis showed an increase in transmittance and a decrease in optical bandgap energy with Mg doping. Photoluminescence spectra revealed a quenching of near band edge emission and red emission for Zn0.96Mg0.04O film. The deposits emitted nearly white light.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Nanoscience & Nanotechnology
Aristide Djoulde, Tebogo Lucky Mamela, Weilin Su, Lingli Kong, Hongzhou Wang, Jinbo Chen, Jinjun Rao, Pengfei Zhao, Li Ma, Jun Yang, Zhiming Wang, Mei Liu
Summary: This study demonstrates a low-cost and feasible method for electrical characterization of semiconducting oxide nanowires. By utilizing tungsten nanoprobes and a nanomanipulation system, stable contacts were established for direct electrical measurements on individual and overlapped zinc oxide nanowires. The results provide valuable information on the intrinsic electrical properties of metal/semiconductor interfaces, with potential applications in nanoelectronic devices.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sihai Luo, Andrea Mancini, Rodrigo Berte, Bard H. Hoff, Stefan A. Maier, John C. de Mello
Summary: The reported technique allows for tuning the gap-width from more than 30 nm to less than 3 nm, enabling the fabrication of molecular rectifiers. It also describes a method for fabricating massively parallel nanogap arrays with nanometric size control over large areas, which exhibit strong plasmonic resonances and act as high-performance substrates for surface-enhanced Raman spectroscopy. These methods extend the range of metallic nanostructures that can be fabricated over large areas and have potential applications in molecular electronics, plasmonics, and biosensing.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Analytical
Ting-Ting Liang, Xiaoling Qin, Yuanhang Xiang, Yujin Tang, Fan Yang
Summary: This review summarizes the recent advances in nucleic acids-mediated extracellular vesicles (EVs) detection, with a focus on electrochemical strategies. It highlights the contribution of nucleic acids, particularly DNA self-assembly structures, in analyzing EVs with high sensitivity. Furthermore, it discusses the challenges and future perspectives of electric EVs detection strategies in clinical applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Kazuma Yoda, Yoshiyasu Ichikawa, Masahiro Motosuke
Summary: This paper presents a newly developed high-throughput measurement device for determining the dielectric properties of cancer cells. The device utilizes continuous-flow electrorotation to measure the rotational behavior of cells, resulting in a significant improvement in throughput compared to conventional devices.
Review
Chemistry, Physical
Ying-Yi Tang, Yang Shen, Jing-Kun Wang, Xiao-Yan Qian, Ming-Lei Guo, Yan-Qing Li, Jian-Xin Tang
Summary: Metal halide perovskite (MHP) materials show great advantages over conventional semiconductors in next-generation optoelectronics due to their outstanding photophysical properties and easy solution processability. Suitable micro-nanostructures have been proven to be an essential strategy for improving the luminescent characteristics of MHP-based optoelectronics. The systematic review and discussion of the fabrication techniques, practical applications, challenges, and prospects of micro-nanostructures in MHP-based luminescence applications have been conducted.
Review
Chemistry, Multidisciplinary
Veikko Linko, Hang Zhang, Nonappa, Mauri A. Kostiainen, Olli Ikkala
Summary: Colloids encompass a wide range of particles, including synthetic nanoparticles and functional biological units. While synthetic colloids have been extensively researched, they often suffer from imperfections in size, shape, and interactions. In contrast, biological colloids offer precision in these aspects. Inspired by biological systems, materials science is exploring ways to achieve structural control and novel functionality in synthetic colloids. This includes guided assemblies of biological motifs, DNA nanotechnology-based assemblies, and atomically precise structures. The goal is to develop stimulus-responsive colloids with complex functions, similar to biological learning. By controlling colloidal size and dispersity, various functionalities can be achieved.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yang Xin, Petteri Piskunen, Antonio Suma, Changyong Li, Heini Ijas, Sofia Ojasalo, Iris Seitz, Mauri A. Kostiainen, Guido Grundmeier, Veikko Linko, Adrian Keller
Summary: The internal design of DNA nanostructures plays a crucial role in determining their behavior in different environments. Crossover design can optimize the performance and stability of these structures, particularly in biomedical applications.
Review
Multidisciplinary Sciences
Petteri Piskunen, Rosalind Latham, Christopher E. West, Matteo Castronovo, Veikko Linko
Summary: Precise genome editing with CRISPR/Cas allows for potential medical applications, while structural DNA nanotechnology provides a platform for accurate positioning of nanomaterials. The combination of these fields enables customizable and impactful nanotechnological applications.
Review
Biochemical Research Methods
Sofia Julin, Adrian Keller, Veikko Linko
Summary: Hierarchical assembly of programmable DNA frameworks, such as DNA origami, has paved the way for versatile nanometer-precise parallel nanopatterning up to macroscopic scales. However, the dynamics of large-scale lattice assembly of such modules is still poorly understood. This article focuses on the dynamics of two-dimensional surface-assisted DNA origami lattice assembly and prospective three-dimensional assemblies, and summarizes their potential applications.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sofia Julin, Veikko Linko, Mauri A. A. Kostiainen
Summary: DNA nanotechnology allows for the fabrication of nanometer-precise templates with various uses. While most DNA assemblies are static, there is an increasing focus on dynamic structures. The programmability of DNA enables the encoding of shape and mechanism of action of dynamic structures. However, these features are usually demonstrated on small, discrete objects rather than large-scale systems.
Article
Chemistry, Physical
Kosti Tapio, Charlotte Kielar, Johannes M. Parikka, Adrian Keller, Heini Jarvinen, Karim Fahmy, J. Jussi Toppari
Summary: In recent years, DNA has been used as a promising material for fabricating hierarchical nanostructures due to its self-assembly properties and functionalization schemes. This study demonstrates the assembly of a two-dimensional fishnet-type lattice on a silicon substrate using cross-shaped DNA origami. The effects of environmental and structural factors on lattice assembly are investigated, and a methodology for producing closely-spaced DNA origami lattices on silicon substrate is developed.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Veikko Linko, Adrian Keller
Summary: Programmable, custom-shaped, and nanometer-precise DNA origami nanostructures have been widely used in bionanotechnology and biomedicine. This review focuses on the structural stability of DNA origami under physiological conditions, exploring the molecular-level interactions and summarizing the role of different interactions in maintaining or changing the integrity and stability of DNA origami nanostructures. It also identifies specific areas that require further investigation. This review provides a primer for designing stable DNA objects and using them in applications involving physiological media.
Article
Chemistry, Multidisciplinary
Paul Williamson, Petteri Piskunen, Heini Ijas, Adrian Butterworth, Veikko Linko, Damion K. Corrigan
Summary: Electrochemical DNA (e-DNA) biosensors are effective tools for disease monitoring, as they can translate hybridization events into recordable electrical signals. In this study, a strategy for amplifying electrochemical signals associated with DNA hybridization was reported using DNA origami method, leading to an improved sensor limit of detection and high strand selectivity. This approach could address the sensitivity requirements for low-cost point-of-care devices.
Article
Nanoscience & Nanotechnology
Iris Seitz, Sharon Saarinen, Esa-Pekka Kumpula, Donna McNeale, Eduardo Anaya-Plaza, Vili Lampinen, Vesa P. Hytoenen, Frank Sainsbury, Jeroen J. L. M. Cornelissen, Veikko Linko, Juha T. Huiskonen, Mauri A. Kostiainen
Summary: DNA and RNA origami nanostructures can be used to control the size, shape, and topology of virus capsids, while also protecting encapsulated origami structures from degradation.
NATURE NANOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Arpan Dutta, J. Jussi Toppari
Summary: Organic thin film based excitonic nanostructures have shown great potential in resonant nanophotonics as an alternative to plasmonic systems. The concentration of excitonic molecules in the film plays a crucial role in realizing surface excitonic modes and optimizing their optical performance. Our study investigates the effect of molecular concentration on various surface excitonic modes and their performance in sensing and spectroscopy. The results show that the optical performance of excitonic systems can be tuned by adjusting the molecular concentration, unlike plasmonic systems. This research provides valuable information for the development of novel excitonic nanodevices in organic nanophotonics.
OPTICAL MATERIALS EXPRESS
(2023)
Article
Chemistry, Multidisciplinary
Johannes M. Parikka, Heini Jarvinen, Karolina Sokolowska, Visa Ruokolainen, Nemanja Markesevic, Ashwin K. Natarajan, Maija Vihinen-Ranta, Anton Kuzyk, Kosti Tapio, J. Jussi Toppari
Summary: Bottom-up methods using molecules like DNA have gained attention for the fabrication of complex nanostructures due to their low cost, high resolution, and simplicity in the third dimension. In this study, plus-shaped Seeman tile (ST) origami formed elongated 2D lattices and rolled into 3D tubes under specific ionic conditions. Imaging and further studies revealed ribbon-like structures with single or double layers of the origami lattice. The assembly process of these 3D DNA origami tubes was found to be heavily dependent on the concentration of mono- and divalent cations, with nickel acting as a trigger for tubular formation in solution.
Article
Chemistry, Multidisciplinary
Kabusure M. Kabusure, Petteri Piskunen, Jiaqi Yang, Veikko Linko, Tommi K. Hakala
Summary: We present efficient SERS supporting substrates based on DNA-assisted lithography and a layered configuration of materials. The hybrid nanostructures consisting of aligned silver bowtie-shaped particles and apertures in a silver film demonstrated a four-fold improvement in Raman enhancement compared to conventional particle-based substrates. Our findings were confirmed by experiments and simulations. The optically resonant substrates fabricated using the versatile and parallel DNA origami-based nanofabrication scheme are attractive for various SERS-based applications.
Article
Chemistry, Multidisciplinary
Spyridon Korkos, Kai Arstila, Kosti Tapio, Sami Kinnunen, J. Jussi Toppari, Timo Sajavaara
Summary: Shape modification of embedded nanoparticles by swift heavy ion (SHI) irradiation is an effective way to produce nanostructures with controlled size, shape, and orientation. Gold nanorods embedded in SiO2 and spherical metallic nanoparticles embedded in Al2O3 were irradiated with SHI. The nanorods re-oriented along the ion beam direction, while the nanoparticles elongated. Dark-field spectroscopy revealed two discrete peaks corresponding to longitudinal and transverse modes in the elongated nanoparticles.
Article
Chemistry, Multidisciplinary
Sofia Julin, Nadine Best, Eduardo Anaya-Plaza, Eeva Enlund, Veikko Linko, Mauri A. Kostiainen
Summary: Stimuli-responsive lipid-DNA origami fibers were formed through electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades under UV-A light and allows controlled release of 6HBs from the fibers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kabusure M. Kabusure, Petteri Piskunen, Jiaqi Yang, Mikko Kataja, Mwita Chacha, Sofia Ojasalo, Boxuan Shen, Tommi K. Hakala, Veikko Linko
Summary: In this study, optically resonant substrates fabricated using the BLIN technique with DNA origami templates were investigated. The optical characteristics of origami-shaped silver nanoparticle patterns on glass surfaces were characterized using optical transmission measurements and surface-enhanced Raman spectroscopy (SERS). The higher SERS enhancement observed for the bowtie structures was found to be primarily due to spectral overlap of the optical resonances with the Raman transitions of the dye molecules. The results demonstrate the potential of the BLIN method for parallel and high-throughput substrate manufacturing with engineered optical properties, and also highlight the possibility of using DNA origami for more complex nanopatterns in various optical applications.