期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 594, 期 6, 页码 1601-1605出版社
WILEY-BLACKWELL
DOI: 10.1113/JP270567
关键词
-
资金
- American Heart Association
- National Institutes of Health (NIH) [HL121456, AG/HL-19291, HL-066023]
- Nova Southeastern University, NIH [HL-113905]
- Pilot Award from Translational Technologies Component of the Georgetown/Howard Universities Center for Clinical and Translational Science [UL1TR000101]
- American Heart Association (Midwest Affiliate) [10GRNT4470043]
AUG sequences and short open reading frames are commonly present in the 5-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with activities biased for one, but not all, of the signalling cascades activated by angiotensin II, which could have therapeutic implications for the myriad hormones and neurotransmitters that signal through G protein-coupled receptors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据