Article
Pharmacology & Pharmacy
Xujun Ruan, Yan Wang, Lirong Zhou, Qiuling Zheng, Haiping Hao, Dandan He
Summary: The discovery of disease biomarker based on untargeted metabolomics is important for studying pathological mechanisms and facilitating early disease diagnosis. This study evaluated the sample preparation, data processing procedure, and metabolite identification strategy for the discovery of breast cancer biomarkers. The optimized strategy simplified the process of exploring differential metabolites, laying a foundation for biomarker discovery and disease mechanism studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
See Ling Loy, Jieliang Zhou, Liang Cui, Tse Yeun Tan, Tat Xin Ee, Bernard Su Min Chern, Jerry Kok Yen Chan, Yie Hou Lee
Summary: The study identified potential biomarkers for peritoneal endometriosis in peritoneal fluid and serum using metabolomics analysis. Phenylalanyl-isoleucine showed promising discriminatory performance in distinguishing peritoneal endometriosis from controls, particularly in the proliferative phase. Further research is needed to validate these findings and assess the clinical utility of phenylalanyl-isoleucine as a diagnostic biomarker for peritoneal endometriosis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Hyebin Choi, Sora Mun, Eun-Jeong Joo, Kyu Young Lee, Hee-Gyoo Kang, Jiyeong Lee
Summary: A proteomic study identified prothrombin as a potential biomarker for MDD, showing significantly increased levels in depressive patients and its association with platelet hyper-activation. This suggests prothrombin could be used for screening, prognosis, and diagnosis of MDD.
Article
Oncology
David A. Drew, Samuel J. Klempner, Andrew T. Chan
Summary: Early detection and interception of gastric cancer globally is limited, especially for individuals without established hereditary risk factors. Establishing biomarkers using multiple-omic approaches may be crucial for identifying individuals at risk and for more intensive evaluation. Multifactorial risk assessment is needed for precision prevention and early detection of gastric cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Pharmacology & Pharmacy
Qi Xiao, Fangfei Zhang, Luang Xu, Liang Yue, Oi Lian Kon, Yi Zhu, Tiannan Guo
Summary: This paper summarizes the advances and limitations of biomarkers in cancer research, as well as the important applications of mass spectrometry technology in proteomics. The article emphasizes the role of artificial intelligence technology in clinical studies, as well as the importance of combining computational and statistical methods in biomarker research.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Oncology
Andrea Romano, Tea Lanisnik Rizner, Henrica Maria Johanna Werner, Andrzej Semczuk, Camille Lowy, Christoph Schroeder, Anne Griesbeck, Jerzy Adamski, Dmytro Fishman, Janina Tokarz
Summary: Endometrial cancer, the most common gynaecological malignancy, has a high incidence and mortality rate in developed countries. There is a need for non/minimally invasive tools for diagnosis and prognosis to manage the increasing number of women at risk. Biomarkers from proteomics and metabolomics can be used to develop such tools, and this review explores the current research in this field. A systematic review of published studies using proteomics and/or metabolomics for biomarker discovery in endometrial cancer is provided, along with recommendations for future studies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemical Research Methods
Wen Chen, Jun Rao, Zhiwen Liu, Xiaolong You, Fenqian Yuan, Fei Le, Mu Tang, Meng Zhou, Ting Xie
Summary: This study comprehensively revealed the molecular characteristics of cutaneous squamous cell carcinoma (CSCC) by performing integrated tissue proteomic and metabolomic analyses, identifying significantly distinct profiles and enriched pathways associated with CSCC, including DNA damage responses. Protein digestion & absorption and platelet activation were both enriched in the proteome and metabolome, suggesting significant roles in CSCC development. Additionally, a four-metabolite panel was developed to distinguish CSCC with high accuracy, providing potential diagnostic biomarkers and extending knowledge on the pathogenesis of CSCC.
JOURNAL OF PROTEOMICS
(2021)
Article
Nutrition & Dietetics
Stefania Noerman, Jyrki K. Virtanen, Marko Lehtonen, Carl Brunius, Kati Hanhineva
Summary: The study aimed to identify fasting serum metabolites associated with whole grain intake in a free-living population. The findings suggested strong associations between whole grain intake and several metabolites, which remained significant even after adjusting for potential confounders. These metabolites have the potential to serve as robust biomarkers for whole grain consumption.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Oncology
Andrew Gold, Fouad Choueiry, Ning Jin, Xiaokui Mo, Jiangjiang Zhu
Summary: Colorectal Cancer (CRC) is a leading cause of cancer-related death in the United States and current diagnosis techniques lack sufficient sensitivity. Metabolomics is a promising technique for identifying CRC biomarkers with high sensitivity and specificity, but it is rarely used in clinical settings. This study conducted a systematic review of recent literature on the detection of CRC biomarkers through metabolomics, identifying dysregulated metabolites across different biospecimens. The study also highlighted the interplay between the gut microbiome and perturbed metabolites in CRC. The findings demonstrate the value of metabolomics as a promising diagnostic technique for CRC.
Article
Virology
Michael Belshan, Alexander Holbrook, Joseph W. George, Hannah E. Durant, Michael Callahan, Spencer Jaquet, John T. West, Jacob Siedlik, Pawel Ciborowski
Summary: The study identified candidate biomarkers of latency in HIV-infected cells by comparing the membrane proteomes of latently infected Jurkat cell lines. Several proteins with significantly altered expression were found, with three factors showing consistent changes across multiple cell lines. The variable expression of most biomarkers across different cell clones suggests a multiplex approach may be needed for universal detection of latently infected cells.
Article
Medicine, Research & Experimental
Qi Chen, Xi Liang, Tianzhou Wu, Jing Jiang, Yongpo Jiang, Sheng Zhang, Yanyun Ruan, Huaping Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li, Yinghe Xu
Summary: This study used untargeted metabolomics and proteomics analysis to investigate the serum of patients with sepsis, revealing the pathological mechanisms of sepsis. The results showed widespread dysregulation of amino acid metabolism in sepsis patients, and identified predictive metabolites associated with sepsis. The study also found that the pentose phosphate pathway was related to sepsis-associated encephalopathy, and phenylalanine metabolism was associated with sepsis-associated acute kidney injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Donghui Lao, Rong Liu, Jianying Liang
Summary: By applying metabolomics, potential biomarkers for AIDS patients have been identified and verified, suggesting their potential role in the diagnosis of HIV/AIDS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Yu
Summary: This review summarizes the progress made in the discovery of reliable Alzheimer's disease (AD) biomarkers using genomics, transcriptomics, proteomics, and metabolomics. The importance of these biomarkers in the diagnosis and treatment of AD is discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Weiwei Lin, Fatemeh Mousavi, Benjamin C. Blum, Christian F. Heckendorf, Jarrod Moore, Noah Lampl, Mark McComb, Sergei Kotelnikov, Wenqing Yin, Nabil Rabhi, Matthew D. Layne, Dima Kozakov, Vipul C. Chitalia, Andrew Emili
Summary: This study used mass spectrometry to detect small molecules and proteins in the serum of hemodialysis patients. It identified several elevated molecules associated with cardiovascular disease and suggested potential drug discovery strategies for understanding disease progression in these patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Zhengyuan Shi, Chunjing Yang, Xiqiao Xu, Wanshui Wu, Dechun Jiang, Dan Yan
Summary: By analyzing plasma samples of children with medulloblastoma and comparing them with samples from children with other intracranial tumors, this study identified differential metabolites and metabolic pathways. The results showed significant differences in glycerophospholipid and alpha-linolenic acid metabolism pathways, as well as amino acid metabolism pathways (phenylalanine, tyrosine, and tryptophan biosynthesis) between medulloblastoma patients and other tumor patients. These findings provide a basis for early diagnosis, as well as identifying new therapeutic targets and strategies for medulloblastoma.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)