Article
Immunology
Kedir N. Turi, Tebeb Gebretsadik, Tan Ding, Andrew Abreo, Cosby Stone, Tina Hartert, Pingsheng Wu
Summary: This study revealed that prenatal antibiotic exposure dose-dependently affects the risk of childhood asthma, with early exposure during pregnancy and the use of broad-spectrum antibiotics associated with a higher risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Tsung-Lin Tsai, Shu-Li Wang, Chia-Jung Hsieh, Hui-Ju Wen, Chin-Chi Kuo, Huei-Ju Liu, Chien-Wen Sun, Mei-Lien Chen, Ming-Tsang Wu
Summary: This study found that prenatal exposure to inorganic arsenic and coexposure to inorganic arsenic and cadmium were associated with a higher risk of atopic dermatitis in young children. These findings suggest that prevention of exposure to inorganic arsenic and cadmium during pregnancy may be helpful for the control of atopic dermatitis and other potential allergies in children.
Review
Nutrition & Dietetics
Alexandru Cosmin Pantazi, Cristina Maria Mihai, Adriana Luminita Balasa, Tatiana Chisnoiu, Ancuta Lupu, Corina Elena Frecus, Larisia Mihai, Adina Ungureanu, Mustafa Ali Kassim Kassim, Antonio Andrusca, Maria Nicolae, Viviana Cuzic, Vasile Valeriu Lupu, Simona Claudia Cambrea
Summary: The intestinal microbiota is a diverse and complex microecosystem that stabilizes by the age of three and plays a crucial role in human health, particularly in early childhood. Dysbiosis has been linked to the development of allergic diseases, such as atopic dermatitis, asthma, and food allergies. Next-generation sequencing methods have improved our understanding of the relationship between dysbiosis and allergic diseases. This review paper aims to synthesize the current knowledge on the development of the intestinal microbiota, its long-term impact on health, and the connection between dysbiosis and allergic diseases, as well as interventions for prevention and treatment.
Article
Multidisciplinary Sciences
Jennifer K. Straughen, Alexandra R. Sitarik, Ganesa Wegienka, Christine Cole Johnson, Tisa M. Johnson-Hooper, Andrea E. Cassidy-Bushrow
Summary: This study examines the association between antimicrobials used during pregnancy and the risk of attention deficit hyperactivity disorder (ADHD) in children. The results show that maternal prenatal antifungal use and frequent prenatal antibiotic use are associated with an increased risk of ADHD in offspring at age 10.
Article
Allergy
Sergio Souza da Cunha, Gillian Santorelli, Neil Pearce, John Wright, Sam Oddie, Emily Petherick, Lucy Pembrey
Summary: The study of 12,476 children showed an association between prenatal exposure to antibiotics and postnatal exposure to antibiotics with an increased risk of asthma in children, especially in those exposed postnatally where the risk of asthma increased with the number of prescriptions. The effect was lower among children with mothers of Pakistani ethnicity, and the interaction between prenatal and postnatal exposures was inconclusive. The population attributable risk of postnatal exposure for asthma was 4.6%.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Medicine, General & Internal
Myrtha E. Reyna, Ruixue Dai, Maxwell M. Tran, Vanessa Breton, Maria Medeleanu, Wendy Y. W. Lou, Rachel E. Foong, Melanie Emmerson, Christoffer Dharma, Kozeta Miliku, Diana L. Lefebvre, Elinor Simons, Meghan B. Azad, Moira Chan-Yeung, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Graham L. Hall, Theo J. Moraes, Malcolm R. Sears, Padmaja Subbarao
Summary: Despite advances in asthma therapeutics, the burden of asthma is still highest in preschool children. This study developed and evaluated a symptom-based screening tool to detect preschool children at high risk of asthma and persistent wheeze symptoms. The tool, called CHART, showed good predictive accuracy and could be easily incorporated into primary care settings.
Article
Environmental Sciences
Jian Cheng, Shilu Tong, Hong Su, Zhiwei Xu
Summary: Short-term exposure to ambient air pollution, particularly ozone and nitrogen dioxide, is associated with an increased risk of childhood asthma exacerbations within a few hours. The risk varies among different age groups and genders in response to different pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Gabrielle Kang-Auger, Thuy Mai Luu, Nancy Low, Aimina Ayoub, Nathalie Auger
Summary: Prenatal cannabis use disorders may predict future childhood injuries from motor vehicle crashes, with the risk increasing with the child's age. Other drug use disorders during pregnancy were not associated with pediatric transport-related injuries.
PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Bo Yan, Zhenke He, Shixin Dong, Hailati Akezhuoli, Xin Xu, Xiaomin Wang, Xudong Zhou
Summary: This study found that parents with good skills in antibiotic identification are less likely to engage in inappropriate antibiotic usage. Additionally, parents with good antibiotic use skills are also less likely to self-medicate or request antibiotics when seeking care. Therefore, it is recommended to strengthen antibiotic identification skills in addition to antibiotic use skills in health education.
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Shaoli Li, Feilong Chen, Chunlei Huang, Guimin Huang, Yijing Cheng, Tao Li, Dongqing Hou, Wenqian Liu, Tao Xu, Junting Liu
Summary: This study investigated the relationship between antibiotic exposure and asthma in adults in the United States. The results showed that the risk of asthma was significantly increased in participants who had recently used macrolide derivatives, penicillin, and quinolones. The association between different types of antibiotics and asthma varied in different age groups and between genders. Other factors such as socioeconomic status, BMI, age, smoking habits, infections, and medical history were also identified as risk factors for asthma. Therefore, stricter regulation of antibiotic use is necessary.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Humanities, Multidisciplinary
Michiyo Okada, Yoshihiro Nakadoi, Ai Fujikawa
Summary: This study explores the relationship between depression and self-rated health, highlighting the importance of children's assessments of their health in driving adolescent suicide rates in Japan. The study utilizes a questionnaire combining text and illustrations, finding that self-rated health decreases and depressive conditions worsen with age. The study underscores the significance of monitoring children's health in educational settings.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Immunology
Mariam Younas, Julie Royer, Hana R. Winders, Sharon B. Weissman, P. Brandon Bookstaver, Julie Ann Justo, Katie S. Waites, Linda Bell, Majdi N. Al-Hasan
Summary: This population-based retrospective cohort study found that increased influenza vaccination coverage was temporally associated with a decrease in ambulatory antibiotic use in children. After adjusting for yearly vaccine effectiveness, the antibiotic prescription rate decreased by 3/1000 person-months for each 1% increase in influenza vaccination coverage between 2012 and 2017 in South Carolina (P < 0.001).
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Respiratory System
Ivy Fong, Jingqin Zhu, Yaron Finkelstein, Teresa To
Summary: This study revealed that antibiotic use is more common among children and youths with asthma compared to those without asthma, especially in the youngest age group and in females.
Article
Pediatrics
Hong Zhang, Kang Xu, Zhihui Liu, Yuanmei Shi, Hui Li, Xiaoping Yin
Summary: Intrapartum antibiotic prophylaxis of group B streptococcus may increase the cumulative incidence and risk of food allergy in children under 18 months old, but it had no significant effect on children under three years old.
FRONTIERS IN PEDIATRICS
(2022)
Article
Psychology, Clinical
C. S. Kubu, T. Frazier, B. Lapin, R. Naugle
Summary: The study demonstrates that models based on a small number of tests can accurately identify neuropsychological impairment in a general adult neuropsychology clinic. These models also show strong predictive validity in a slightly different sample. Test protocols using only five to eight test scores can accurately identify most patients with clinical impairment in a diverse adult neuropsychology clinic.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Immunology
Brittany Lapin, Kevin W. Garey, Henry Wu, V Sissi, Shirley P. Huang, Pat Ray Reese, Elaine Wang, Abhishek Deshpande
Summary: In a post hoc analysis of 182 outpatients included in a phase 3 clinical trial, we demonstrated the reliability, validity, and responsiveness of a 32-item disease-specific questionnaire (Cdiff32) for patients with recurrent Clostridioides difficile infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Brittany Lapin, Irene L. Katzan
Summary: This study evaluated the ability of utilizing items on a global health measure to identify patients who may require additional screening. The results showed that these items can be used as screening tools to identify patients with poor scores on additional construct-specific outcomes. By directing construct-specific assessments to applicable patients, survey burden could be reduced, leading to a more efficient and targeted use of PROMs in healthcare decision-making.
QUALITY OF LIFE RESEARCH
(2023)
Article
Clinical Neurology
Nimish J. Thakore, Brittany R. Lapin, Hiroshi Mitsumoto
Summary: The study found that riluzole reduces the risk of death uniformly, regardless of the time from onset to treatment and duration of treatment. Additionally, early initiation of treatment with riluzole may result in greater absolute survival gains from onset.
Article
Medicine, General & Internal
Kevin W. Garey, Jinhee Jo, Anne J. Gonzales-Luna, Brittany Lapin, Abhishek Deshpande, Elaine Wang, Brooke Hasson, Sissi V. Pham, Shirley P. Huang, Pat Ray Reese, Henry Wu, Elizabeth Hohmann, Paul Feuerstadt, Caterina Oneto, Charles S. Berenson, Christine Lee, Barbara McGovern, Lisa vonMoltke
Summary: This secondary analysis of a phase 3 clinical trial investigated the association of SER-109 with health-related quality of life (HRQOL) in patients with recurrent Clostridioides difficile infection (CDI). The study found that SER-109 was associated with significant improvements in HRQOL compared to placebo, indicating its potential as an important treatment option for CDI patients.
Article
Behavioral Sciences
Vineet Punia, Yadi Li, Brittany Lapin, Pradeep Chandan, Christopher Newey, Stephen Hantus, Monika Dhakar, Clio Rubinos, Sahar Zafar, Adithya Sivaraju, Irene L. Katzan
Summary: The study aims to evaluate the impact of ASyS and ASMs on PROMs in stroke patients. A retrospective cohort study was conducted, including all stroke patients who underwent inpatient cEEG monitoring. The results showed that ASM use was associated with ASyS diagnosis, but there were no significant differences in PROMs based on ASyS status, ASM use at hospital discharge, or ASM status on the day of PROM completion.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Michael P. Phelan, Nicolas R. Thompson, Zubair Ahmed, Brittany Lapin, Belinda Udeh, Eric Anderson, Irene Katzan, Laura E. Walker
Summary: This study aimed to compare the clinical characteristics between outpatient headache clinic patients who self-report visiting the emergency department for headache and those who do not. The results showed that there were significant differences in age, race, insurance status, and area deprivation index between patients who reported emergency department utilization and those who did not. Additionally, worse patient-reported outcome measures were associated with a higher risk of emergency department utilization.
Article
Clinical Neurology
Zubair Ahmed, Ryan Honomichl, Stephen F. Thompson, Joshua M. Cohen, Andrew Schuster, Nicolas R. Thompson, Brittany Lapin, Belinda L. Udeh, Verena Ramirez Campos, Lynda J. Krasenbaum, Irene L. Katzan
Summary: This study compared the clinical and demographic characteristics of patients with chronic migraine (CM) and episodic migraine (EM) in a hospital headache clinic, and investigated the effect of migraine subtype on patient-reported outcome measures (PROM). The results showed that CM patients reported more severe headaches, poorer quality of life, and higher levels of psychological health problems compared to EM patients.
Letter
Health Care Sciences & Services
Cinthya Pena-Orbea, Brittany Lapin, Yadi Li, Kristin Englund, Catherine Heinzinger, Nancy Foldvary-Schaefer, Reena Mehra
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Clinical Neurology
Brittany Lapin, Yadi Li, Sara Davin, Mary Stilphen, Joshua K. Johnson, Edward Benzel, Ghaith Habboub, Irene L. Katzan
Summary: This study aimed to compare the performance of different stratification techniques for subgrouping patients with chronic low back pain. The results showed that all four techniques had good validity and prognostic utility, with ISS and LCA symptom clusters being the optimal methods. Future research should explore multidisciplinary treatment approaches based on these techniques for mild, moderate, and severe patients.
Article
Multidisciplinary Sciences
Helen Valsamis, Samah Abdul Baki, Jason Leung, Samer Ghosn, Brittany Lapin, Geetha Chari, Izad-Yar Rasheed, Jaehan Park, Vineet Punia, Ghinwa Masri, Dileep Nair, Ann Marie Kaniecki, Muhammad Edhi, Carl Y. Saab
Summary: This study found significant changes in brain rhythms in COVID-19 patients through quantitative and qualitative analysis of electroencephalography (EEG), especially in patients below the age of 70. These findings are important for understanding the long-term effects of COVID-19 on brain function and the utility of EEG monitoring in COVID-19 patients.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Shilpa C. Rao, Yadi Li, Brittany Lapin, Sreya Pattipati, Kamalini Ghosh Galvelis, Anna Naito, Nicolas Gutierrez, Thiago Peixoto Leal, Amira Salim, Philippe A. Salles, Maria De Leon, Ignacio F. Mata
Summary: Parkinson's disease (PD) is an age-related neurological disorder that shows differences in risk, progression, and severity between men and women. This study aimed to identify women-specific health experiences associated with PD severity by developing and distributing a women-specific questionnaire and creating multivariable models. The results found significant associations between major depressive disorder, perinatal depression, natural childbirth, LRRK2 genotype, B12 deficiency, total hysterectomy, and increased PD severity. This study provides important insights into the etiology of PD and highlights the role of sex-specific experiences.
NPJ PARKINSONS DISEASE
(2023)
Review
Health Care Sciences & Services
Brittany Lapin, Matthew L. Cohen, Nadia Corsini, Alyssa Lanzi, Sarah C. Smith, Antonia V. Bennett, Nancy Mayo, Rebecca Mercieca-Bebber, Sandra A. Mitchell, Claudia Rutherford, Jessica Roydhouse
Summary: This study aims to explore methodological guidelines for proxy reporting in adult populations and develop relevant considerations. Through a review of literature and clinical assessment measures, it was found that there is inconsistency in the definition of proxy reporting in adult populations and a lack of considerations for proxy selection and data collection, analysis, and reporting. Therefore, a checklist of considerations for proxy reporting is provided to assist researchers and clinicians in using proxy reporting in research and clinical care.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Health Care Sciences & Services
Nicolas R. Thompson, Brittany R. Lapin, Irene L. Katzan
Summary: This study aimed to evaluate and compare estimated utilities based on PROPr and PROMIS-GH in adult stroke survivors. The results showed that all three PROMIS-based utilities were associated with measures of stroke disability and severity, but the distributions of utilities were very different. Therefore, different utility measurement methods need to be considered when assessing health states.
MEDICAL DECISION MAKING
(2023)
Editorial Material
Clinical Neurology
A. B. Sullivan, S. A. Davin, B. Lapin, A. T. Schuster, R. A. Dweik, K. F. Murray, S. J. Rehm, A. G. Machado
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)