Article
Nutrition & Dietetics
Karel Kalecky, Paula Ashcraft, Teodoro Bottiglieri
Summary: This study explores the alterations in one-carbon metabolism in Alzheimer's disease (AD) and Parkinson's disease (PD), and finds a potential link between levodopa-carbidopa therapy and dementia in PD patients, as well as the correlation between betaine and cognitive score in PD patients.
Review
Pharmacology & Pharmacy
De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Yan Wang, Ming-Xing Li, Jing-Yi Qiao
Summary: The study found that the clinical efficacy of P+LB combination therapy in Parkinson's disease patients is superior to that of LB monotherapy, with a better safety profile.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: Our study reveals the potential effectiveness of GPi-DBS in treating camptocormia in PD patients, showing significant improvement in patients' postural deformity. Pre-surgical TCC angle, levodopa responsiveness of the TCC angle, and structural connectivity from volume of tissue activated to somatosensory cortex are closely associated with improvement in the TCC angle.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Yasuhiko Baba, Akinori Futamura, Ryuta Kinno, Shohei Nomoto, Seiya Takahashi, Taro Yasumoto, Yuyuko Osakabe, Daiki Shoji, Yoko Nabeshima
Summary: This study assessed the duration from initiation of levodopa/DCI to the emergence of motor fluctuations in patients with PD and found that levodopa/carbidopa therapy with a DCI to levodopa ratio of 1:10 may delay the occurrence of motor fluctuations when compared to levodopa/benserazide therapy with that of 1:4.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Cell Biology
Thomas Mueller, Eugen Schlegel, Stephanie Zingler, Hans Michael Thiede
Summary: The catechol-O-methyltransferase inhibitors entacapone and opicapone prolong the efficacy of conventional oral levodopa/dopa decarboxylase inhibitor formulations through an increase in levodopa plasma bioavailability. The study compared the impact of single-day entacapone or opicapone intake on the pharmacokinetic plasma behavior of levodopa, 3-O-methyldopa, and total homocysteine in Parkinson's disease patients. It was found that opicapone had higher levodopa bioavailability and better baseline scores compared to entacapone.
Review
Health Care Sciences & Services
Daniel van Poppelen, Annelie N. M. Tromp, Rob M. A. de Bie, Joke M. Dijk
Summary: Based on a retrospective case series and literature review, it was found that patients with Parkinson's disease who have persisting medication related motor response fluctuations despite DBS or CLI treatment may benefit from an additional or alternative treatment with either CLI or DBS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Jin Hee Kim, Shaoyue Jin, Hyeyoon Eo, Myung Sook Oh, Yunsook Lim
Summary: This meta-analysis investigated the impact of Levodopa and COMT inhibitors on levels of homocysteine, vitamin B-12, and folate in Parkinson's disease patients. The results showed that Levodopa treatment was associated with increased Hcy levels and decreased vitamin B-12 and folate levels, while COMT inhibitors were found to decrease Hcy and vitamin B-12 levels and increase folate levels compared to Levodopa treatment.
Article
Chemistry, Physical
Tianqi Nie, Zhiyu He, Jinchang Zhu, Kuntao Chen, Gregory P. Howard, Jesus Pacheco-Torres, Il Minn, Pengfei Zhao, Zaver M. Bhujwalla, Hai-Quan Mao, Lixin Liu, Yongming Chen
Summary: A non-invasive method involving sub-50 nm nanoparticles loaded with L-DOPA was successfully developed to deliver the drug to the brain through brain-lymphatic vasculature. Pharmacodynamics analysis in a PD rat model showed significant improvement in dopamine and tyrosine hydroxylase levels, along with movement disorders and cerebral oxidative stress. The formulation exhibited high biocompatibility and holds promise for clinical treatment of Parkinson's disease.
Article
Neurosciences
Gaia Meoni, Leonardo Tenori, Sebastian Schade, Cristina Licari, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Paola Turano, Claudia Trenkwalder, Claudio Franceschi, Brit Mollenhauer, Claudio Luchinat
Summary: Parkinson's disease is the neurological disorder with the highest increase in prevalence. The lack of precise diagnosis at early stages remains a challenge. Metabolomics has provided valuable insights into the molecular basis of PD and potential biomarkers for early detection and treatment efficacy. In this study, NMR was used to analyze serum samples from German PD patients, revealing more pronounced pathological characteristics in male patients and confirming altered levels of acetone and cholesterol. Additionally, stronger oxidative stress markers were detected.
NPJ PARKINSONS DISEASE
(2022)
Article
Entomology
Jingjing Li, Fangfang Li, Na Yu, Zewen Liu
Summary: Homocysteine metabolism plays a crucial role in spider species, and the BRP pathway is essential in P. pseudoannulata.
Review
Clinical Neurology
Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Pedro Garcia-Ruiz, Per Odin, Peter Riederer, Thomas Mueller
Summary: Emerging studies show a correlation between elevated plasma homocysteine levels and the risk of atherosclerosis, vascular disorders, and neurodegenerative diseases. This review explores the intricate relationships between homocysteine, vitamin B metabolites, dopamine-substituting compounds, and various symptoms of Parkinson's disease (PD). Patients on a long-term L-dopa/dopa-decarboxylase inhibitor regimen without concurrent catechol-O-methyl transferase (COMT) inhibitor or methyl group-donating vitamin supplementation exhibit higher homocysteine levels and decreased vitamin B metabolites, which are associated with an increased risk of non-motor symptoms including peripheral neuropathy and cognitive disturbances. The review highlights the impact of levodopa metabolism via COMT on homocysteine levels and suggests methyl group-donating vitamin supplementation, particularly with vitamins B6 and B12, for patients on a high-dose L-dopa/DDI regimen, especially those treated with L-dopa/carbidopa intestinal gel infusion.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Koji Fujita, Shichun Peng, Yilong Ma, Chris C. Tang, Matthew Hellman, Andrew Feigin, David Eidelberg, Vijay Dhawan
Summary: In this study, rubidium-82 (Rb-82) PET was used to quantify blood-brain barrier (BBB) permeability in 19 Parkinson's disease (PD) patients, including those with levodopa-induced dyskinesia (LID). The results showed that there were no significant changes in BBB permeability in PD patients, regardless of LID status.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Yifan Yang, Feng Gao, Li Gao, Jiaodan Miao
Summary: This study examined the effects of Resagiline, levodopa, and benserazide hydrochloride on motor performance, serum homocysteine (Hcy) levels, and insulin-like growth factor (IGF-1) in patients with intermediate to severe Parkinson's disease. The results showed that the combination treatment significantly lowered Hcy levels, increased IGF-1 levels, and improved motor function in the patients.
Review
Medicine, General & Internal
Bastiaan R. Bloem, Michael S. Okun, Christine Klein
Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.
Article
Clinical Neurology
Marina Picillo, Onanong Phokaewvarangkul, Yu-Yan Poon, Cameron C. McIntyre, Sinem Balta Beylergil, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
Summary: This study compared the efficacy and safety of levodopa versus dopamine agonist monotherapy after deep brain stimulation in Parkinson's disease. Results showed that in short- and mid-term follow-up, more than half of patients were able to safely continue monotherapy, with levodopa patients having a higher likelihood. In the long term, only a minority of patients were able to maintain levodopa monotherapy, while dopamine agonist monotherapy was not well tolerated.
MOVEMENT DISORDERS
(2021)
Article
Chemistry, Multidisciplinary
Marzieh Rashidipour, Zohreh Derikvand, Ardeshir Shokrollahi, Zahra Mohammadpour, Azadeh Azadbakht
ARABIAN JOURNAL OF CHEMISTRY
(2017)
Article
Physiology
Bahram Rasoulian, Zahra Hajializadeh, Saeed Esmaeili-Mahani, Marzieh Rashidipour, Iman Fatemi, Ayat Kaeidi
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2019)
Article
Chemistry, Medicinal
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
PHYTOTHERAPY RESEARCH
(2018)
Article
Food Science & Technology
Marzieh Rashidipour, Rouhollah Heydari, Afshin Maleki, Ebrahim Mohammadi, Behroz Davari
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2019)
Article
Chemistry, Applied
Behnam Ashrafi, Marzieh Rashidipour, Abdolrazagh Marzban, Setareh Soroush, Mojgan Azadpour, Somayeh Delfani, Parvin Ramak
CARBOHYDRATE POLYMERS
(2019)
Article
Agriculture, Multidisciplinary
Marzieh Rashidipour, Afshin Maleki, Sajad Kordi, Mehdi Birjandi, Naser Pajouhi, Ebrahim Mohammadi, Rouhollah Heydari, Reza Rezaee, Bahram Rasoulian, Behroz Davari
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shabnam Sattari, Abbas Dadkhah Tehrani, Mohsen Adeli, Khadijeh Soleimani, Marzieh Rashidipour
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Genetics & Heredity
Seyed Sajad Sohrabi, Seyyed Mohsen Sohrabi, Marzieh Rashidipour, Mohsen Mohammadi, Javad Khalili Fard, Hossein Mirzaei Najafgholi
Article
Nanoscience & Nanotechnology
Saber Abbaszadeh, Marzieh Rashidipour, Peyman Khosravi, Soroosh Shahryarhesami, Behnam Ashrafi, Mozhgan Kaviani, Mostafa Moradi Sarabi
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Chemistry, Medicinal
Behnam Ashrafi, Fatemeh Beyranvand, Fatemeh Ashouri, Marzieh Rashidipour, Abdolrazagh Marzban, Farnaz Kheirandish, Saeed Veiskarami, Parvin Ramak, Somayeh Shahrokhi
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Plant Sciences
Behnam Ashrafi, Marzieh Rashidipour, Elham Gholami, Ehsan Sattari, Abdolrazagh Marzban, Farnaz Kheirandish, Mojtaba Khaksarian, Morovat Taherikalani, Setareh Soroush
SOUTH AFRICAN JOURNAL OF BOTANY
(2020)
Article
Medicine, Research & Experimental
Mahmoud Bahmani, Morovat Taherikalani, Mojtaba Khaksarian, Mahmoud Rafieian-Kopaei, Behnam Ashrafi, Mohammadreza Nazer, Setareh Soroush, Naser Abbasi, Marzieh Rashidipour
Article
Entomology
Asghar Sepahvand, Behrouz Ezatpour, Masuumeh Niazi, Marzieh Rashidipour, Mohammad Reza Aflatoonian, Mojtaba Mirshekari Soleimani
ENTOMOLOGY AND APPLIED SCIENCE LETTERS
(2018)
Article
Chemistry, Analytical
Marzieh Rashidipour, Rouhollah Heydari
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Pouya Parsaei, Zohreh Eftekhari, Marzieh Rashidipour, Mahmoud Rafieian-Kopaei
INTERNATIONAL JOURNAL OF ADVANCED BIOTECHNOLOGY AND RESEARCH
(2017)