Article
Nutrition & Dietetics
Sylvie Tagliati, Simona Barni, Mattia Giovannini, Giulia Liccioli, Lucrezia Sarti, Tatiana Alicandro, Erika Paladini, Giancarlo Perferi, Chiara Azzari, Elio Novembre, Francesca Mori
Summary: Nut allergies are increasingly common in Italian children, with hazelnuts and walnuts being common allergens. Clinical manifestations include anaphylaxis and gastrointestinal symptoms, with a majority of patients having a family history of allergy or concomitant allergic disorders.
Review
Allergy
Annick Barbaud, Julie Castagna, Angele Soria
Summary: Skin tests, including patch tests, prick tests, and intradermal tests, are valuable in identifying the causes of cutaneous adverse drug reactions and finding safer alternative drugs. Patch tests are useful in studying maculopapular exanthema and severe drug reactions, including acute generalized exanthematous pustulosis and drug reaction with eosinophilia and systemic symptoms. Prick tests are used to evaluate immediate-type hypersensitivity, while intradermal tests can be used for both immediate and delayed-type hypersensitivity reactions.
CONTACT DERMATITIS
(2022)
Review
Allergy
Ying Xin Teo, Peter Simon Friedmann, Marta Ewa Polak, Michael Roger Ardern-Jones
Summary: Skin tests, particularly patch tests and intradermal tests, have been reported as valuable tools in assessing drug causality in DRESS. However, the heterogeneity in methodology, results analysis, and reporting of cohorts make it impossible to determine the sensitivity and specificity of the published literature. International collaboration is needed to harmonize the methodology and reporting measures in larger hypersensitivity testing studies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Agriculture, Dairy & Animal Science
Vera Carvalho Pessoa, Manuel Branco-Ferreira, Sigridur Jonsdottir, Eliane Marti, Paula Tilley
Summary: By testing IBH-affected horses, it was found that specific allergens Cul n WBE, Cul n 7, 8, 9, Cul o1P, and Cul o 2P performed the best in skin prick tests, showing a strong diagnostic potential. The sulfidoleukotriene release assay performed the best in in vitro tests.
Article
Allergy
Antonino Romano, Rocco Luigi Valluzzi, Cristiano Caruso, Alessandra Zaffiro, Donato Quaratino, Francesco Gaeta
Summary: This study evaluated the usefulness of skin tests and challenges in 236 subjects with immediate reactions to cephalosporins, finding that most of these reactions are IgE-mediated. Cephalosporin skin testing is a useful tool for evaluating these reactions, and IgE-mediated cephalosporin hypersensitivity may be a transient condition.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Allergy
Hye-Ryun Kang, Jiung Jeong, Knut Brockow
Summary: Iodinated contrast media (ICM) can cause drug hypersensitivity reactions (HSRs), and there is currently a lack of standardized strategies for diagnosis and prevention. A history of hypersensitivity to ICM is the main risk factor, and avoiding the culprit agents and taking preventive measures are the main strategies. Skin tests can help identify sensitized ICM, and ICM provocation test can be useful in selected cases.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Allergy
Juliette Caron, Sahara Graf, Christine Delebarre-Sauvage
Summary: Among patients with immediate hypersensitivity reactions to iodinated contrast media, the rate of confirmed allergic patients by positive skin tests was 8.1%. Despite negative skin test results, 12.5% of re-exposed patients experienced recurrent hypersensitivity reactions. Additional investigations on pure intradermal tests to contrast media and development of drug provocation tests could provide a safety net for detecting recurrent reactors. Agreement among allergists is necessary to standardize practices.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Allergy
Caroline Beutner, Christian Wrobel, Tobias Dombrowski, Dirk Beutner, Susann Forkel, Timo Buhl
Summary: Skin prick tests (SPTs) are commonly used for diagnosing allergic rhinitis (AR), but the inclusion of specific allergens in the test panels is still debated. A study investigated patients with inconsistent SPT results for birch, alder, and hazel trees, and found that more than half showed negative SPT results for birch but positive results for alder/hazel. Serological assessments revealed polysensitization and the presence of other positive SPT results for different plants. The study highlights the importance of considering clinical symptoms and using molecular markers for accurate diagnosis.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Dermatology
Raheleh Shokouhi Shoormasti, Maryam Mahloujirad, Nastaran Sabetkish, Anoushirvan Kazemnejad, Vahid Ghobadi Dana, Behnoosh Tayebi, Javid Morad Abbasi, Homa Sadri, Mohammad Reza Fazlollahi, Zahra Pourpak, Mostafa Moin
Summary: The skin prick test is a useful method for identifying sensitization patterns to common inhalant and food allergens. Russian thistle and lamb's quarter were the most common aeroallergens, while shrimp and peanut were the most common food sensitizers for patients with atopic dermatitis and chronic urticaria. Strategies for prevention and treatment, such as removing weeds, avoidance, and immunotherapy, are crucial for better disease control.
DERMATOLOGIC THERAPY
(2021)
Review
Allergy
Priya Sellaturay, Shuaib Nasser, Pamela Ewan
Summary: This study reports 5 cases of confirmed PEG allergy, with most cases related to medications containing PEGs. Skin tests showed positive reactions in 3 cases, with 2 cases experiencing allergic reactions following the intradermal test.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Medicine, General & Internal
Constantinos Pitsios, Emilia Vassilopoulou, Katerina Pantavou, Ingrid Terreehorst, Anna Nowak-Wegzryn, Antonella Cianferoni, Georgios Panagiotis Tsigkrelis, Maria Papachristodoulou, Stefanos Bonovas, Georgios K. Nikolopoulos
Summary: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disorder linked to sensitization to food and airborne allergens. Dietary manipulations using allergy tests have been successful in managing EoE inflammation. However, the correlation between allergen detection by these tests and confirmed triggers of EoE is generally low to moderate. Combining multiple tests can improve the positive predictive value. Allergy-based elimination diets have been estimated to be efficient in 66.7% of the cases, but further research is needed to improve the guidance for elimination diets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Ewa Cichocka-Jarosz, Piotr Brzyski, Urszula Jedynak-Wasowicz, Nina Mol, Barbara Klasa, Zofia Mazurek-Durlak, Grzegorz Lis, Anna Nowak-Wegrzyn
Summary: This study aimed to assess the usefulness of skin prick tests (SPT) as the immunological marker in the diagnosis of insect venom sensitization in children. The results showed that SPTs are not an useful immunological marker of venom sensitization in children, and limiting diagnostics to venom specific IgE (sIgE) and intradermal tests (IDT) would shorten the procedure and reduce costs.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Dermatology
Leticia Talita Baretta, Victor do Espirito Santo Cunha, Cristiane Deon Figueiredo, Daniel Guimaraes Gerardi
Summary: This study evaluated the influence of the drugs oclacitinib and prednisolone on the immediate-phase reactions of intradermal (IDT) and prick (PT) tests. The results showed that oclacitinib may reduce PT reactivity, while prednisolone resulted in a reduction in both IDT and PT results.
VETERINARY DERMATOLOGY
(2023)
Article
Immunology
Emanuele Nappi, Francesca Racca, Alessandra Piona, Maria Rita Messina, Sebastian Ferri, Donatella Lamacchia, Giuseppe Cataldo, Giovanni Costanzo, Lorenzo Del Moro, Francesca Puggioni, Giorgio Walter Canonica, Enrico Heffler, Giovanni Paoletti
Summary: Concerns have been raised about hypersensitivity reactions in patients with allergic reactions to drugs containing polyethylene glycol (PEG) or polysorbate 80 (PS80), excipients of currently available anti-SARS-CoV-2 mRNA vaccines. The utility of PEG and PS80 skin allergy testing is still debated. In a retrospective analysis, a significant proportion of patients tested positive for PEG and/or PS80, indicating the importance of testing for allergy to these excipients.
Review
Allergy
Carmen Riggioni, Cristian Ricci, Beatriz Moya, Dominic Wong, Evi van Goor, Irene Bartha, Betul Buyuktiryaki, Mattia Giovannini, Sashini Jayasinghe, Hannah Jaumdally, Andreina Marques-Mejias, Alexandre Piletta-Zanin, Anna Berbenyuk, Margarita Andreeva, Daria Levina, Ekaterina Iakovleva, Graham Roberts, Derek Chu, Rachel Peters, George du Toit, Isabel Skypala, Alexandra F. Santos
Summary: This study conducted a systematic review and meta-analysis on diagnostic tests for IgE-mediated food allergy. It found that skin prick test and specific IgE to extracts had high sensitivity, while specific IgE to components and basophil activation test had high specificity for the diagnosis of individual food allergies.
Letter
Allergy
M. T. Krishna, P. A. J. Huber, S. M. Nasser, P. W. Ewan, A. T. Clark
CLINICAL AND EXPERIMENTAL ALLERGY
(2016)
Letter
Allergy
Priya Sellaturay, Pamela Ewan
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2016)
Article
Allergy
L. Diwakar, P. Ewan, P. A. J. Huber, A. Clark, S. Nasser, M. T. Krishna
CLINICAL AND EXPERIMENTAL ALLERGY
(2016)
Letter
Allergy
Priya Sellaturay, Shuaib Nasser, Pamela Ewan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2018)
Article
Allergy
Shelley Dua, James Dowey, Loraine Foley, Sabita Islam, Yvonne King, Pamela Ewan, Andrew T. Clark
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2018)
Editorial Material
Allergy
Adam T. Fox, Paul Turner, Pamela W. Ewan
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Article
Allergy
Shelley Dua, Monica Ruiz-Garcia, Simon Bond, Stephen R. Durham, Ian Kimber, Clare Mills, Graham Roberts, Isabel Skypala, James Wason, Pamela Ewan, Robert Boyle, Andrew Clark
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Review
Allergy
Priya Sellaturay, Shuaib Nasser, Pamela Ewan
Summary: This study reports 5 cases of confirmed PEG allergy, with most cases related to medications containing PEGs. Skin tests showed positive reactions in 3 cases, with 2 cases experiencing allergic reactions following the intradermal test.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Letter
Allergy
Priya Sellaturay, Shuaib Nasser, Sabita Islam, Padmalal Gurugama, Pamela W. Ewan
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Priya Sellaturay, Padmalal Gurugama, Verah Harper, Tom Dymond, Pamela Ewan, Shuaib Nasser
Summary: The study investigated the safety of vaccinating PEG-allergic patients with the AstraZeneca COVID-19 vaccine. The results showed that all eight patients allergic to PEG tolerated the AstraZeneca COVID-19 vaccine, even in cases where the skin prick tests for PS80 and the vaccine itself were positive. This suggests that there may not be a clinical cross-reactivity between PEG and PS80 in this specific vaccine setting.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Letter
Allergy
Verah Harper, Padmalal Gurugama, Pamela Ewan, Shuaib Nasser, Priya Sellaturay
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Allergy
Susan C. Leech, Pamela W. Ewan, Isabel J. Skypala, Nicola Brathwaite, Mich Erlewyn- Lajeunesse, Sarah Heath, Heidi Ball, Polly James, Karen Murphy, Andrew T. Clark
Summary: This guideline provides recommendations for the diagnosis and management of patients with egg allergy, highlighting the importance of avoiding severe allergic reactions and providing appropriate guidance based on clinical presentation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Letter
Allergy
Elizabeth Angier, Deepa Choudhury, David Luyt, Sarah Baker, Amena Warner, Andrew Clark, Pamela Ewan
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Biographical-Item
Allergy
Pamela Ewan, Shuaib Nasser
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
G. Stiefel, K. Anagnostou, R. J. Boyle, N. Brathwaite, P. Ewan, A. T. Fox, P. Huber, D. Luyt, S. J. Till, C. Venter, A. T. Clark
CLINICAL AND EXPERIMENTAL ALLERGY
(2017)