Review
Polymer Science
Fangfei Liu, Xiong Liu, Feng Chen, Qiang Fu
Summary: Polysaccharides are natural biopolymers with fascinating properties that have been widely used in biomedical applications. Chemical modifications, including mussel-inspired chemistry, offer a significant means to enhance the functionalities of polysaccharides and broaden their applications in biomedicine. The mussel-inspired strategy can give polysaccharides unique properties and provide a platform for the fabrication of diverse hybrid materials with specific functionalities.
PROGRESS IN POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Chao Zhang, Li Xiang, Jiawen Zhang, Chang Liu, Zuankai Wang, Hongbo Zeng, Zhi-Kang Xu
Summary: This study reveals a previously unexplored adhesion mechanism in mussel-inspired chemistry, where 5,6-dihydroxyindole (DHI) moieties play a crucial role, challenging the conventional belief of catechol-dominated adhesion. The high adhesion strength of polydopamine (PDA) is attributed to the abundant yield of DHI moieties achieved through oxidation and cyclization during self-polymerization, suggesting that substituent chemistry and self-polymerization can govern adhesion in mussel-inspired materials.
Article
Nanoscience & Nanotechnology
Yongqi Zhang, Jia Man, Jianing Liu, Jianyong Li, Xinzhong Song, Jiali Wang, Jianfeng Li, Yuguo Chen
Summary: In this study, a mussel-inspired composite coating consisting of polydopamine, lysine, and modified heparin was constructed to reduce thrombosis and enhance the anticoagulant capability of medical devices. The results showed that the composite coating significantly inhibited platelet adhesion and activation, prolonged activated partial thromboplastin time, and exhibited excellent hemocompatibility and anticoagulant properties. This research demonstrates great potential for anticoagulant treatment in medical devices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Ali Taghizadeh, Mohsen Taghizadeh, Mohsen Khodadadi Yazdi, Payam Zarrintaj, Joshua D. Ramsey, Farzad Seidi, Florian J. Stadler, Haeshin Lee, Mohammad Reza Saeb, Masoud Mozafari
Summary: After billions of years, nature still serves as inspiration for developing new technologies and materials. Wet and strong adhesion by Mytilidae mussels has inspired the development of advanced adhesives for moist conditions. A deep understanding of the chemical moieties and microenvironmental conditions involved in wet adhesion is essential for optimal design. Muscle-inspired chemistry has versatile applications in various fields, particularly in bioengineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Polymer Science
Pedro M. Costa, David A. Learmonth, David B. Gomes, Mafalda P. Cautela, Ana C. N. Oliveira, Renato Andrade, Joao Espregueira-Mendes, Tiago R. Veloso, Cristiana B. Cunha, Rui A. Sousa
Summary: Biomaterials have shown limitations in adhesion to biological tissues under wet conditions, but the substitution of gellan gum with dopamine may offer a solution. Studies have demonstrated that replacing polymers of natural or synthetic origin with dopamine or other catechol moieties greatly improves adhesion to biological tissues.
Article
Chemistry, Multidisciplinary
Buyun Chen, Kun Lei, Dandan Zhu, Chongchong Yang, Chengyuan Sun, Wei Xiao, Zhen Zheng, Xinling Wang
Summary: The study presents a mussel mimetic polyurethane as a topological suture material for tough adhesion of hydrogels by introducing catechol moieties into polymer chains. This innovative adhesion strategy achieves excellent adhesion strength to versatile substrates without the need for specific functional groups or chemical modification. Additionally, the adhesion energy achieved by the topological stitching strategy can reach up to 350 J m(-2), showing potential for debonding under the catalysis of elastase.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yongliang Ouyang, Yizhou Zhao, Xiaoyi Zheng, Yao Zhang, Jiulong Zhao, Shige Wang, Yubei Gu
Summary: In this study, a multifunctional bio-hemostatic hydrogel (CODM) was prepared using modified alginate, polyvinylpyrrolidone (PVP), and carboxymethyl chitosan. The addition of amino group-modified montmorillonite improved the hemostatic ability of the hydrogel, making it better than commercial hemostatic materials. The CODM hydrogel also demonstrated photothermal conversion ability and antibacterial properties, making it a promising candidate for emergency hemostasis and wound management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Xinting Han, Lulu Ren, Yan Ma, Xiao Gong, Hangxiang Wang
Summary: In this study, a self-repairing superhydrophobic coating with good anti-corrosion and photothermal properties was fabricated by the spaying method. The coating exhibited excellent corrosion resistance and was capable of self-repairing under sunlight. This research provides a new idea for the application of superhydrophobic coatings.
Article
Nanoscience & Nanotechnology
Qin Yao, Jinyi Zhang, Guoqing Pan, Binghai Chen
Summary: Long-term indwelling catheters or stents often cause complications such as infection and encrustation. This study developed an antibacterial coating on urinary stents/catheters using a clickable mussel-inspired peptide and antimicrobial peptide. The coating exhibited excellent stability, bactericidal properties, and improved biological compatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rong-chen Xu, Fan Yu, Guo-lei Xiang, Xiao-yu Wang, Zun-han Hu, Li Huang, Lin Liu, Long-yan Duan, Qian Liu, Li-na Niu, Franklin R. Tay, Ji-hua Chen, Hong-bo Li
Summary: By incorporating DMA into etchants, the durability of resin-dentine bonding was improved by enhancing collagen stability and inhibiting collagenase activity, potentially prolonging the longevity of bonded dental restorations.
JOURNAL OF DENTISTRY
(2022)
Article
Materials Science, Multidisciplinary
Li Cheng, Chengbao Liu, Hao Wu, Haichao Zhao, Feixiong Mao, Liping Wang
Summary: The study reports the application of polydopamine microcapsules as novel nanocontainers for self-healing and anti-corrosion protection of carbon steel, demonstrating improved protective performance of coatings and the synergistic enhancement of self-healing properties and anti-corrosion performance.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Wen Zhao, Meng Zhang, Huijin Li, Yao Du, Qiuxiang Bu, Lan Cao, Chengzhong Zong
Summary: An innovative bioinspired method using poly(dopamine) (PDA) was developed to modify nanodiamonds (ND) particles to improve the thermal conductivity and insulation capability of silicone rubber. The poly(dopamine) coating on ND particles improved their interfacial interaction with silicone rubber and promoted the uniform dispersion of fillers, resulting in a significant enhancement in thermal conductivity without compromising the insulation property.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
W. Yu, Y. Cui, M. Han, P. Jia, Y. Zhao, M. Zhang, Y. Sun, R. Nian
Summary: Hydrogels have great potential as skin dressings but need to overcome their poor mechanical strength. This study reinforced poly(ethylene glycol) diacrylate/alginate double network hydrogels with a crosslinker from mussel-inspired chemistry, resulting in improved mechanical strength, antifatigue and self-healing properties, and high ductility. The hydrogels also showed antioxidant activity, conductivity, bioadhesiveness, and transparency, making them highly promising for use in skin dressings.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Polymer Science
Kai-Yi Chang, Ying-Nien Chou, Wei-Yu Chen, Chuh-Yean Chen, Hong-Ru Lin
Summary: This study develops a multi-functional hydrogel with a dual injection system based on the adhesive and self-healing properties of the byssus excretion found in mussels. The hydrogel has high strength, temperature sensitivity, good adhesion, self-healing properties, and antibacterial resistance. It can be used for deep wound treatment and improvement of traditional wound dressings.
Article
Chemistry, Multidisciplinary
Zeynab Tavasolyzadeh, Peng Tang, Marc Benjamin Hahn, Gada Hweidi, Niclas Nordholt, Rainer Haag, Heinz Sturm, Ievgeniia Topolniak
Summary: This work combines mussel-inspired materials with advanced microfabrication techniques to achieve high-resolution and customizable 2D and 3D microstructures. These structures have extensive post-functionalization capabilities and have been successfully applied in DNA detection and silver nanoparticle modification.
Article
Engineering, Environmental
Huan Liu, Shuai Li, Luping Feng, Yue Hua, Yuanyuan Cai, Mengyuan Yin, Yuqi Wan, Hua Wang
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Engineering, Environmental
Lixiang Zhang, Pan Li, Luping Feng, Xi Chen, Jiatian Jiang, Sheng Zhang, Chunxian Zhang, Anchao Zhang, Guofu Chen, Hua Wang
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Xi Chen, Wenwen Zhang, Lixiang Zhang, Luping Feng, Chunxian Zhang, Jie Jiang, Hua Wang
Summary: A selective photoelectrochemical sensor has been developed using g-C3N4 nanosheets treated with N-2 plasma to deposit Cd probes for signal-on detection of H2S. The Cd/N@g-C3N4 nanocomposites exhibit enhanced photocurrent responses to H2S under visible light irradiation due to the formation of efficient CdS heterojunctions. This novel sensing platform shows promise for applications in environmental monitoring, food safety, and biomedical analysis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Xiurong Zhai, Fan Xu, Yujiao Li, Fangying Jun, Shuai Li, Chunxian Zhang, Hua Wang, Bingqiang Cao
Summary: Silver-doped ZnO nanorods arrays grown in-situ onto ITO via one-pot hydrothermal route show highly selective and recyclable electroanalysis of phosphothioate pesticides, with good detection performance and photocatalytic degradation efficiency.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Environmental
Mengyuan Yin, Yuqi Wan, Shuai Li, Xiaoting Zhao, Wenwen Zhang, Yun Zhang, Hua Wang
Summary: Mesoporous melamine-silver nanocomposites doped with carbon nitride quantum dots were fabricated through controlled supramolecular self-assembly. The resulting nanoflower-like nanocomposites exhibited peroxidase-like catalysis, which could be enhanced by Hg2+ and effectively detoxify Hg-0 in wastewater through visible-light-driven photocatalysis. These nanocomposites also showed high Hg adsorption capability and promise for environmental monitoring and wastewater treatment of toxic heavy metals.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xi Chen, Wenwen Zhang, Lixiang Zhang, Luping Feng, Chunxian Zhang, Jie Jiang, Hua Wang
Summary: The porous In2S3@In2O3 composites, prepared by special treatment, exhibited efficient photocatalytic production of H2O2 in pure water, showing promising application prospects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Xiurong Zhai, Shuai Li, Yukun Wang, Siyu Cao, Wen Sun, Mingzhu Liu, Guojiang Mao, Bingqiang Cao, Hua Wang
Summary: A magnet-renewable electroanalytical strategy has been developed for monitoring hydrogen sulfide (H2S) in aquaculture freshwater systems using magnetic Fe3O4-loaded silver metal-organic framework (Fe3O4@Ag-MOF). The method exhibits sensitive and stable signals with rational signal decline in the presence of H2S. The electrodes can be easily renewed for immobilization of Fe3O4@Ag-MOF probes, facilitating detection in aquaculture freshwater samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Jizhen Shang, Yuchun Qiao, Guojiang Mao, Lisheng Qian, Guodong Liu, Hua Wang
Summary: The electrochemical H1N1 RNA beacons were designed and shown to effectively treat drug-resistant H1N1 viruses with the BLM-Fe(II) agent. The BLM-Fe(II) agent can cleave both dsRNAs and ssRNAs of H1N1 at selective cutting sites, indicating its potential to block viral-host infection and inactivate viruses. Clinical validation confirmed the efficiency of BLM-Fe(II) in controlling new strains of H1N1 virus. This study highlights the potential of BLM-Fe(II) as a therapeutic gene drug and the use of RNA beacons for drug screening.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Chunxian Zhang, Shuai Li, Zhiqiang Duan, Qin Li, Mengxuan Zhao, Yulong Chen, Xiurong Zhai, Guojiang Mao, Hua Wang
Summary: Water-soluble non-conjugated polymer dots were synthesized using hyperbranched polyethyleneimine and dihydroxybenzaldehyde for the first time. These polymer dots exhibited strong green fluorescence in aqueous media and could be quenched by MnO2 nanosheets and restored by thiocholine. A highly selective fluorimetric method for detecting organophosphorus pesticides was developed based on these characteristics.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Luping Feng, Lixiang Zhang, Su Chu, Sheng Zhang, Xi Chen, Yushuang Gong, Zhongling Du, Guojiang Mao, Hua Wang
Summary: A nanozyme with a 2D/1D heterostructure, SWCNTs@MoS2, was successfully fabricated and demonstrated improved peroxidase-like catalysis, along with selective detection of glutathione (GSH). A colorimetric method based on SWCNTs@MoS2 was proposed for quantitative analysis of GSH, showing potential for extensive applications in clinical laboratory settings. This study opens up possibilities for designing various nanozymes with enhanced catalytic activity.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Chenchen Xu, Qingqing Liu, Su Chu, Pan Li, Fengxiang Wang, Yanmei Si, Guojiang Mao, Choufei Wu, Hua Wang
Summary: A microdots array-based fluoremetric method with superwettability profile was developed for simultaneous and separate detection of Fe3+ and Cu2+ ions in red wine samples. The fluoremetric microdots array platform was obtained by designing a wettable micropores array and immobilizing fluorescent probes in it. The platform enabled the accumulation of targeting ions without tedious preprocessing and reduced cross-contamination. The feasibility of simultaneous and separate detection of Fe3+ and Cu2+ ions in red wine samples was demonstrated.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yuchun Qiao, Yu Fang, Jizhen Shang, Xiaoting Zhao, Shuai Li, Guojiang Mao, Hua Wang
Summary: In this study, a fluorescent test strip with suppressed CRE of silver nanocluster probes coated by gelatin was successfully fabricated using vacuum-aided fast lyophilization, enabling uniform and stable probe deposition as well as sensitive quantitative analysis.
Article
Materials Science, Biomaterials
Sheng Zhang, Luping Feng, Pan Li, Lixiang Zhang, Xi Chen, Su Chu, Yuan Gao, Shujing Xie, Jiatian Jiang, Hua Wang
Summary: A highly selective and sensitive photoelectrochemical detection method using ZnO@CdS heterojunctions was developed for the analysis of copper ions. The rational combination of photosensitive catalyst and visible-light sensitizer enhanced the detection of Cu2+ ions with linear concentrations in blood.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Pan Li, Lixiang Zhang, Sheng Zhang, Chenchen Xu, Yinuo Li, Juan Qu, Shuai Li, Guojiang Mao, Hua Wang
Summary: A high-throughput and selective fluorimetric platform has been developed for analyzing ammonia in blood using a polymer-stabilized metal-organic framework and wettable microwells array construction. Plasma treatment of ITO substrate created a super-hydrophilic interface for wettable microwells array construction, enabling enrichment of targets from sample droplets.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Kelu Yan, Min Liu, Jiangwei Wen, Xiao Liu, Xinyue Wang, Xinyu Chen, Jing Li, Shao Wang, Xiu Wang, Hua Wang
Summary: The visible-light-promoted cascade cyclization of 2-haloaryl isothiocyanates and isocyanides to access benzo[d]imidazo[5,1-b]thiazoles has been efficiently realized under metal- and photocatalyst-free conditions. This protocol offers advantages such as readily available and inexpensive substrates, metal catalyst-free, step and atom economy, and mild reaction conditions.
