Article
Chemistry, Analytical
Huiwen Zhou, Ruanshan Liu, Guangxing Pan, Miaomiao Cao, Ling Zhang
Summary: Noble Metal nanoclusters (NCs) exhibit strong electrochemiluminescence (ECL) signals and excellent biocompatibility. Glutathione-capped AuPt bimetallic NCs (GSH-AuPt NCs) show enhanced ECL signals compared to monometallic Au and Pt NCs, thanks to the synergistic effect of the bimetallic structure. The unique electric and optical properties of GSH-AuPt NCs contribute to their strong ECL emission. A sandwich-type immunoassay using GSH-AuPt NCs as signal tags achieves sensitive and accurate cancer diagnosis with a wide linear range and a lower limit of detection.
Article
Chemistry, Analytical
Tesfaye Hailemariam Barkae, Shuai Quan, Zhiyong Dong, Kaixiang Ji, Altaf Hussain, Abdallah M. Zeid, Guobao Xu
Summary: This study explores the use of gramine as a coreactant in Ru(bpy)(3)(2+) electrochemiluminescence, enabling the detection of gramine in a wide linear range with a low limit of detection. The method was validated using beer samples, showing promising results.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Lu Zheng, Qingfu Guo, Chaonan Yang, Jingjing Wang, Xuejiao Xu, Guangming Nie
Summary: A novel dual-signal immunosensor based on Ru(bpy)32+/MOF (Ru-MOF) composite material is developed for the detection of prostate-specific antigen (PSA) through electrochemiluminescence (ECL) and photoelectrochemistry (PEC). The Ru-MOF film exhibits strong ECL signals coexisted with K2S2O8 and good PEC property under light. By introducing Cu2O-coated Pd shell-core-structured nanoparticles (Pd/Cu2O) as a quencher, the ECL and PEC intensity can be efficiently quenched, allowing successful construction of the dual-signal immune sensor for PSA detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Tong Shao, Xiaolei Song, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei
Summary: A novel electrochemiluminescence (ECL) sensor was developed by combining Zr-based metal organic framework (ZrMOF) and branched polyethylenimine (BPEI)-coated Ru(dcbpy)32+ through electrostatic interaction for nicotine analysis. The constructed ECL sensor displayed ultrasensitive determination of nicotine with a detection limit of 1.9 x 10-12 M, three orders lower than previously reported ECL results and 4-5 orders lower than other types of methods. This method provides a new approach for building efficient ECL system with greatly improved ECL sensitivity for nicotine detection.
Article
Chemistry, Analytical
Yingjie Zhao, Li Tian, Xin Zhang, Zhuo Sun, Xiangyu Shan, Qian Wu, Ruizhan Chen, Juan Lu
Summary: A specificity recognition molecularly imprinted electrochemiluminescence sensor (MIECLS) for determination of clenbuterol (CLB) was established, with a detection limit of 3.3 x 10(-10) mol L-1. The sensor utilized Fe2O3 as the carrier to fix Ru(bpy)(3)(2+), and introduced molecular imprinted membranes (MIPs) with CLB as template molecules to achieve specificity identification, showing great potential in pork and liver samples testing.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xiu-hua Wei, Xing Qiao, Jie Fan, Yuan-qiang Hao, Yin-tang Zhang, Yan-li Zhou, Mao-tian Xu
Summary: A label-free electrochemiluminescence biosensor based on CdS quantum dots and gold nanoparticles was developed for sensitive determination of carcinoembryonic antigen (CEA), with a detection limit of 8.5 x 10(-5) ng/mL. The biosensor showed good analytical performance in detecting CEA in human serum samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Tesfaye Hailemariam Barkae, Abdallah M. Zeid, Shuai Quan, Muhammad Rehan Hasan Shah Gilani, Baohua Lou, Guobao Xu
Summary: A new Ru(bpy)32+ electrochemiluminescence (ECL) system has been developed for sensitive, cost-effective, rapid, and specific detection of Hexamethylphosphoramide (HMPA), with high percentage recoveries in real samples of lake water and waste water. The system enables analysis of HMPA over a wide dynamic range with a low detection limit.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
X. Y. Dong, R. Z. Zhang, T. K. Zhang, F. Y. Liu
Summary: The chemically modified electrode based on bio-MOF-1 showed excellent electrochemiluminescence performance for dopamine detection, with advantages of linear response, quick response, high reproducibility, and low detection limit.
Article
Electrochemistry
Laena D'Alton, Peter Nguyen, Serena Carrara, Conor F. Hogan
Summary: A facile synthesis method of a bimetallic polymer with multiple emissive centers was demonstrated by modifying a partially photolyzed [Ru(bpy)(2)PVP10](2+) with an iridium precursor. The tunable emission color from near-infrared to green by adjusting the ratio of iridium to ruthenium centers was achieved. Transfer of energy between the iridium center and ruthenium centers was observed both in solution-phase and when immobilized as a thin layer, enhancing the electrochemiluminescence properties of the bimetallic polymer.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Jiawen Li, Caiqian Wang, Wenjing Wang, Ling Zhao, Heyou Han
Summary: In this study, a dual-signal immunosensor was developed for highly sensitive detection of rabies virus (RABV) using electrochemiluminescence resonance energy transfer (ECL-RET) and electrochemical (EC) methods. The combination of dendritic mesoporous silica nanoparticles (DMSNs) and manganese oxide nanoparticles (MnOx) allowed for the detection of RABV glycoprotein through two different signaling pathways.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Shuang He, Qiaoling Liu, Yu Ji, Pei Zhang, Chusen Huang, Jing Sun, Yao Lu, Da-Peng Yang, Nengqin Jia
Summary: An electrochemiluminescent (ECL) sensor using Ru(bpy)(3)(2+) encapsulated by MIL-NH2-101(Al) nanocomposites has been developed for the sensitive detection of the thrombus marker thrombomodulin (TM), showing ideal stability, selectivity, and reproducibility.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Xuebo Liu, Liwei Bai, Xiaowei Cao, Feng Wu, Tao Yin, Wenbo Lu
Summary: In this study, a MXene/P-BiOCl/Ru(bpy)32+ heterojunction composite was reported for constructing an electro-chemiluminescence immunosensor for the detection of SARS-CoV-2 nucleocapsid protein. The combination of two-dimensional materials and architectures enabled efficient signal amplification and co-reaction acceleration, resulting in high sensitivity and detection range for the target protein.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Lei Shang, Xiao-Hong Zhao, Wei Zhang, Li-Ping Jia, Rong-Na Ma, Qing-Wang Xue, Huai-Sheng Wang, Ai-Xiang Guo, Lei Si
Summary: In this study, low-potential-driven electrochemiluminescence (ECL) was achieved using graphene-PtPd hybrid, and applied for sensitive detection of carcinoembryonic antigen (CEA). The sandwich signal-off ECL immunosensor showed good specificity, stability, and reproducibility, and successfully detected CEA in actual samples.
Article
Chemistry, Analytical
Jiangwei Li, Yue Hu, Jiao Yang, Yingchun Li
Summary: In this study, [Ru(bpy)(3)](2+) doped mesoporous carbon nanospheres (RMCNs) were synthesized via a one-step approach, and showed enhanced electrochemiluminescence (ECL) emission and stability. The synergistic effects of [Ru(bpy)(3)](2+) doping level, Zeta potential, pore size, and particle size of RMCNs on ECL intensity were systematically studied. By combining with molecularly imprinted polymer (MIP), an ECL sensor with good selectivity and wide detection range for beta-hydroxybutyric acid was developed.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Binxiao Li, Xuedong Huang, Yanwei Lu, Zihui Fan, Bin Li, Dechen Jiang, Neso Sojic, Baohong Liu
Summary: In this study, a designed Ru(bpy)(3)(2+) embedded MOF complex (RuMOFs) is used for high-quality imaging of electrochemiluminescence (ECL) events at a single molecule level. The efficient capture of ECL photons generated inside the MOFs allows for stable ECL emission for up to 1 hour, enabling the visualization of protein movements at the cellular membrane. Compared to fluorescence observation, the near-zero ECL background provides better contrast for dynamic imaging of discrete protein movement.
