☆ 4.5 Article

Electrochemical Sensor Based on Oxidation of 2,8-Dihydroxyadenine to Monitor DNA Damage in Calf Thymus DNA

ELECTROANALYSIS (2011)

期刊

ELECTROANALYSIS

卷 23, 期 6, 页码 1383-1390

出版社

WILEY-V C H VERLAG GMBH

DOI: 10.1002/elan.201000753

关键词

Calf thymus DNA; 2,8-Dihydroxyadenine; Edge plane pyrolytic graphite electrode; Single-wall carbon nanotubes; Square wave voltammetry

类别

Chemistry, Analytical Electrochemistry

资金

Council of Scientific and Industrial Research, New Delhi
Department of Science and Technology, New Delhi

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摘要

A novel and reliable direct electrochemical method has been established to monitor DNA damage in acid hydrolyzed calf thymus DNA, based on the determination of 2,8-dihydroxyadenine (2,8-DHA). A single-wall carbon nanotubes (SWCNT) modified edge plane pyrolytic graphite electrode (EPPGE) has been used as a sensor to monitor the DNA damage. 2,8-DHA the main in vivo adenine oxidation product undergoes oxidation at similar to 395 mV at SWCNT modified EPPGE using square wave voltammetry (SWV). The sensor exhibits potent and persistent electron-mediating behavior. A well-defined oxidation peak for the oxidation of 2,8-DHA was observed at modified electrode with lowering of peak potential and increase in peak current as compared to bare EPPGE. At optimal experimental conditions, the catalytic oxidative peak current was responsive with the 2,8-DHA concentrations ranging from 0.05 nM to 100 nM. The detection limit was 3.8 x 10(-11) M and limit of quantification was 1.27 x 10(-10) M. The modified electrode exhibited high stability and reproducibility.

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