Article
Chemistry, Analytical
Pedro Carneiro, Joana A. Loureiro, Cristina Delerue-Matos, Simone Morais, Maria do Carmo Pereira
Summary: In this study, a sensitive and specific electrochemical immunosensor was developed for the detection and quantification of alpha-synuclein, a biomarker for Parkinson's disease. The immunosensor is based on voltammetric study and uses antibodies to recognize the analyte. The sensor is nanostructured using a layer-by-layer approach and has shown excellent detection capabilities within a certain concentration range.
Article
Electrochemistry
Khanittha Ponsanti, Nipaporn Ngernyuang, Benchamaporn Tangnorawich, Kesara Na-Bangchang, Kanyarat Boonprasert, Adis Tasanarong, Teerachat Saeheng, Akkaracha Hanwattanakul, Chiravoot Pechyen
Summary: This study presents an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles for detecting total hemoglobin and glycated hemoglobin in blood samples. The sensor shows a linear response and reliability, making it a promising approach for sensitive point-of-care testing of HbA1c in diabetes patients.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Biophysics
Tai-Cheng Lu, Yi-Ming Sun, Yu Zhong, Xin-Hua Lin, Yun Lei, Ai -Lin Liu
Summary: In this study, a gold nanoparticles/electrochemically reduced graphene oxide@carbon nanotube modified immunosensor was proposed for P-gp detection in serum using a one-step electrochemical co-reduction method. The detection results in serum were consistent with ELISA. The developed immunosensor is expected to provide a scientific basis for the clinical application of serum P-gp monitoring and integrated medicine.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Physical
Anna Gorska, Marcel Zambrzycki, Beata Paczosa-Bator, Robert Piech
Summary: A new electrochemical sensor based on hierarchical carbon nanofibers with Ni and Co nanoparticles (eCNF/CNT/NiCo-GCE) was developed. The sensor exhibits high sensitivity, good electrical conductivity, and electrocatalytic properties. The optimized method was proven to be accurate and reliable for the determination of cetirizine hydrochloride (CTZ).
Review
Chemistry, Analytical
Zhaoyuan Gong, Yueming Huang, Xianjing Hu, Jianye Zhang, Qilei Chen, Hubiao Chen
Summary: The presence of pesticide and mycotoxin residues in food poses a potential risk to human health. Traditional detection methods, such as HPLC, lack sensitivity and convenience. In recent years, nanotechnology has facilitated the development of electrochemical biosensors based on nanomaterials, which offer rapid and accurate detection of trace amounts of pesticides and mycotoxins. This review examines English articles on electrochemical biosensors published between 2011 and 2022, focusing on various nanomaterials, including noble metals, magnetic nanoparticles, metal-organic frameworks, carbon nanotubes, graphene, and its derivatives. The roles of these nanomaterials in the detection process are discussed, along with the targeted pesticides and mycotoxins. Despite significant progress, challenges still need to be addressed for further advancements in electrochemical nano-biosensors.
Article
Chemistry, Analytical
Melinda David, Adrian Serban, Teodor Adrian Enache, Monica Florescu
Summary: This study described and compared the performances of commercial screen-printed carbon electrodes with different nanostructured materials for LT4 detection. The presence of carbon nanotubes resulted in the best performance for LT4 detection.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Zhiguo Zhang, Ziming Fang, Yina Huang, Bitao Xiong, Xing'ao Li, Huanping Yang
Summary: In this research, a new supercapacitor electrode is developed by growing CNTs on electrochemical exfoliation graphene with few FeCo (G-CNTs-FeCo) using hydrothermal method. The electrode exhibits excellent specific capacitance (560.26 F/g at 1 mV/s) and low charge transfer resistance (30.79 omega). It combines the advantages of graphene, CNTs, and FeCo metals, showing better electron conductivity and electrochemical performance compared to pure graphene. This paper provides a method to enhance the performance of graphene supercapacitors.
Article
Chemistry, Multidisciplinary
Andreas Tsiamis, Francisco Diaz Sanchez, Niklas Hartikainen, Michael Chung, Srinjoy Mitra, Ying Chin Lim, Huey Ling Tan, Norbert Radacsi
Summary: This study presents a scalable method for developing ultrasensitive electrochemical biosensors by maximizing sensor conductivity through graphene wrapping of carbonized electrospun nanofibers. The effectiveness of the graphene wrap was determined visually and chemically, with the graphene-wrapped carbonized nanofiber electrode showing significantly improved performance. Despite inhibitive effects from the carbon glue used, the graphene-wrapped carbonized nanofibers exhibited potential for a highly conductive and inert sensing platform.
Article
Chemistry, Multidisciplinary
Gang Wang, Dan Han, Qingyu Zhang
Summary: This study developed a dual-signal strategy using anodic stripping voltammetry (ASV) and cyclic voltammetry (CV) for highly sensitive detection of circulating tumour cells (CTCs). The dual-signal biosensor overcame the limitations of any single-signal mode and improved the detection reliability and precision.
Article
Chemistry, Physical
Hakimeh Teymourinia, Abbas Al-nayili, Hassan Abbas Alshamsi, Rojin Mohammadi, Esmail Sohouli, Mitra Gholami
Summary: In this study, an electrochemical method using a carbon nano-onions (CNOs)/polyanilin nanotubes (PANI-NTs)/gold nanoparticles (AuNPs) nanocomposite was used to accurately measure ciprofloxacin (CIP), a resistant drug against bacteria. The nanocomposite was synthesized and analyzed, and then used to modify a glassy carbon electrode (GCE) for the measurement of CIP in an aqueous medium. The results showed that the prepared sensor has a good ability to measure CIP in real samples, and the nanocomposite was also capable of degrading CIP in the presence of visible light.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Analytical
Zheng Huang, Hui Song, Linlin Feng, Jinghua Qin, Qianyi Wang, Bingjian Guo, Liuyan Wei, Yating Lu, Hongwei Guo, Dan Zhu, Xiaolong Ma, Yue Guo, Hua Zheng, Mei Li, Zhiheng Su
Summary: An ultrasensitive electrochemical sensor based on graphene oxide-modified multiwalled carbon nanotubes and gold nanoparticles was developed for the detection of free lead ions. By linking the aptamer securely to the sensor surface, the sensor showed excellent selectivity for Pb2+. The sensor exhibited a low detection limit of 7.1 x 10-6 nmol/mL and a linear range of 5 x 10-5-0.2 nmol/mL, making it suitable for practical applications in food and other industries.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Aysu Arman, Sener Saglam, Aysem Uzer, Resat Apak
Summary: The study presented a sensitive detection method for nitroaromatic explosives using a GC/MWCNTs/PEI electrode coated with gold nanoparticles. The method successfully detected TNT, DNT, 2,4-DNP, PA, and tetryl in a linear range, with detection limits ranging from 15 μg L-1 to 135 μg L-1. This method was also validated against the reference LC-MS method for analyzing explosives in soil samples.
Article
Biochemical Research Methods
Nannan Dou, Jianying Qu
Summary: This study synthesized a new electrochemical sensor that can simultaneously detect 4-AP and AC, with a wide linear range and low detection limits. The sensor showed excellent electrocatalytic performance and has potential application prospects in real samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Oluwafunmilola Ola, Habib Ullah, Yu Chen, Kunyapat Thummavichai, Nannan Wang, Yanqiu Zhu
Summary: A synthesis method for iron oxide nanoparticles coated with graphitic carbon nitride (Fe-x-NC) and their improved electrochemical stability and corrosion resistance in an acidic electrolyte environment is reported. The nanocomposites exhibit enhanced activity and long-term stability for the hydrogen evolution reaction in a 0.5 M H2SO4 aqueous solution. The study sheds light on new efficient and durable electrocatalysts for applications in acidic environments.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Anderson M. Santos, Ademar Wong, Maria H. A. Feitosa, Andy A. Cardenas-Riojas, Sandy L. Calderon-Zavaleta, Angelica M. Baena-Moncada, Maria D. P. T. Sotomayor, Fernando C. Moraes
Summary: Nifedipine, a widely used medication, is crucial for blood pressure management in humans. To effectively address this widespread concern, the development of an electrochemical sensor based on a modified glassy carbon electrode was performed, resulting in a highly active electrode surface for the oxidation of nifedipine. This sensor, combined with a voltammetric method, showed excellent performance in detecting nifedipine in biological and environmental samples.
Article
Chemistry, Applied
Diana Pinto, Andreia Almeida, Anallely Lopez-Yerena, Soraia Pinto, Bruno Sarmento, Rosa Lamuela-Raventos, Anna Vallverdu-Queralt, Cristina Delerue-Matos, Francisca Rodrigues
Summary: This study demonstrates the in-vivo antioxidant properties of chestnut shell extract, as well as its protective effects against hemolysis and elevated blood glucose and lipids levels. Additionally, the study provides new insights on the metabolomic profiling of polyphenols.
Review
Biochemistry & Molecular Biology
Renato Caldevilla, Stephanie L. Morais, Agostinho Cruz, Cristina Delerue-Matos, Fernando Moreira, Joao G. Pacheco, Marlene Santos, Maria Fatima Barroso
Summary: Major depressive disorder is commonly treated with antidepressants, but some patients have adverse reactions or inadequate response to treatment. Analytical chromatographic techniques can investigate medication complications, including those associated with antidepressants, but have limitations. Electrochemical (bio)sensors have gained attention due to their cost-effectiveness, portability, and precision. They can be used to monitor antidepressant levels and provide accurate results for personalized treatment and improved patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Filipa Teixeira, Ana Margarida Silva, Cristina Delerue-Matos, Francisca Rodrigues
Summary: Lycium barbarum L. or goji berries are widely used in dietary supplements and natural healthcare products due to their outstanding bioactive properties. They contain a rich composition of phenolic compounds, carotenoids, organic acids, carbohydrates, and vitamins. Consumption of goji berries has been associated with various biological activities such as antioxidant, antimicrobial, anti-inflammatory, prebiotic, and anticancer effects. This review aims to provide a summary of the phytochemical composition, biological activities, and industrial applications of goji berries, as well as the valorization of their by-products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Virginia Cruz Fernandes, Valentina F. Domingues, Marta S. Nunes, Renata Matos, Iwona Kuzniarska-Biernacka, Diana M. Fernandes, Antonio Guerrero-Ruiz, Inmaculada Rodriguez Ramos, Cristina Freire, Cristina Delerue-Matos
Summary: A new application of graphene-type materials combined with GC-ECD/GC-MS/GC-MS/MS detection was used for the simultaneous analysis of 12 brominated flame retardants in Capsicum cultivar samples. The materials showed good adsorption capability and did not compromise the extraction efficiency of target analytes. The developed method exhibited excellent recoveries, good linearity, and low limits of quantification.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sonia Soares, Francisca Rodrigues, Cristina Delerue-Matos
Summary: Honey is a widely consumed natural product with health benefits, and its environmental and ethical aspects influence consumer decision-making. Various methods, including DNA markers, have been developed to assess the quality and authenticity of honey. DNA metabarcoding has become particularly important for studying environmental and biodiversity aspects in honey.
Article
Horticulture
Catarina Macedo, Ana Margarida Silva, Ana Sofia Ferreira, Maria de la Luz Cadiz-Gurrea, Alvaro Ferandez-Ochoa, Antonio Segura-Carretero, Cristina Delerue-Matos, Paulo Costa, Francisca Rodrigues
Summary: Actinidia arguta fruit, also known as kiwiberry, is a promising source of bioactive compounds for health applications. This study aimed to determine the optimal extraction conditions of antioxidant/antiradical compounds from kiwiberry using the Response Surface Methodology. The optimal extract exhibited outstanding antioxidant, antiradical, and antimicrobial activities, and decreased the viability of human carcinoma cell lines.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Analytical
Alvaro Torrinha, Miguel Tavares, Vitoria Dibo, Cristina Delerue-Matos, Simone Morais
Summary: The increase in anthropogenic pollution raises concerns about water and aquatic species contamination, which could have implications for human health. Pharmaceutical compounds, a type of emerging contaminant, are increasingly consumed and found in the aquatic environment. In this study, a simple electrochemical sensor based on untreated carbon fiber paper was used for the analysis of trimethoprim antibiotic in fish samples. The sensor showed comparable performance to commonly used sensors, with a linear range of 0.05 to 2 mu M, sensitivity of 48.8 mu A mu M-1 cm(-2), and LOD of 0.065 mu M. It was successfully applied to trimethoprim determination in fish samples.
Article
Food Science & Technology
Virginia Cruz Fernandes, Martyna Podlasiak, Elsa F. Vieira, Francisca Rodrigues, Clara Grosso, Manuela M. Moreira, Cristina Delerue-Matos
Summary: Global production of exotic fruits has been steadily growing and expanding to other countries over the past decade. Consumption of these fruits, such as kiwano, has increased due to their health benefits. However, there is limited research on the chemical safety of these fruits. Therefore, an optimized analytical method was developed to assess the presence of multiple contaminants in kiwano, including pesticides, PCBs, and brominated flame retardants.
Article
Food Science & Technology
Jessica Ferreira Rodrigues, Cristina Soares, Manuela M. Moreira, Maria Joao Ramalhosa, Neimar Freitas Duarte, Cristina Delerue-Matos, Clara Grosso
Summary: This study evaluates consumer perceptions and acceptance of Moringa oleifera Lam. beverages using a multidisciplinary approach. The study examines sensory attributes, chemical composition, and bioactivities. The findings emphasize the importance of consumer awareness in reading labels, verifying product origins, and ensuring the absence of contaminants. By understanding consumer preferences and the impact of health claims, producers can better tailor M. oleifera beverages to meet consumer expectations while maintaining safety and quality standards.
Article
Chemistry, Multidisciplinary
Jaroslava Svarc-Gajic, Tanja Brezo-Borjan, Valentin Dzedik, Francisca Rodrigues, Simone Morais, Cristina Delerue-Matos
Summary: This research examines the valorization potential of cocoa hull extracts in the cosmetic industry based on Environmental, Social, and Governance (ESG) criteria. The extracts were obtained using subcritical water extraction and characterized for their chemical composition and bioactive properties. Functional cosmetic formulations were developed using cocoa hull extracts from cocoa beans sourced from different geographical locations. The extracts showed high total protein, total phenol, and total flavonoid contents, as well as significant antioxidant and antiradical activities. A functional cosmetic product, a day cream with sun protective properties, was formulated using the extract with the highest antioxidant and antiradical activity. The safety and quality parameters of the cream were analyzed, indicating the viability of using subcritical water extracts of cocoa hull in cosmetic products. The application of subcritical water extraction as a green technology can contribute to ESG development in the cosmetic industry.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Analytical
Shayesteh Bazsefidpar, Maria Freitas, Clara R. Pereira, Gemma Gutierrez, Esther Serrano-Pertierra, Henri P. A. Nouws, Maria Matos, Cristina Delerue-Matos, Maria Carmen Blanco-Lopez
Summary: In this paper, a method for effectively controlling Escherichia coli (E. coli) O157:H7 in milk samples was developed. Monodisperse Fe3O4@Au magnetic nanoparticles were synthesized and used in an electrochemical sandwich-type magnetic immunoassay for rapid and accurate analysis. The assay showed a linear range from 20 to 2 x 10(6) CFU/mL, with a limit of detection of 20 CFU/mL for E. coli O157:H7. The selectivity of the assay was tested and the applicability was demonstrated by analyzing a commercial milk sample.
Review
Biochemistry & Molecular Biology
Ana Margarida Silva, Marco Preto, Clara Grosso, Monica Vieira, Cristina Delerue-Matos, Vitor Vasconcelos, Mariana Reis, Lillian Barros, Rosario Martins
Summary: Alzheimer's disease is a neurodegenerative disease that causes a decline in cognitive functions. It is the most common form of dementia and has no well-defined cause. Current treatments only manage to reduce symptoms, and there are only two drugs that can partially halt its progression. Natural compounds from mushrooms have been studied for their potential use in AD treatment due to their beneficial effects on various AD-related mechanisms such as enzyme inhibition, prevention of protein aggregation and neurotoxicity, and antioxidant and anti-inflammatory potential. While there have been studies linking mushrooms to neurodegenerative diseases, there is currently no publication summarizing the data specifically focused on AD. This review aims to fill that gap by compiling the potential anti-AD effects of mushroom extracts or compounds that target known AD-related mechanisms.
Article
Biochemistry & Molecular Biology
Diana Pinto, Ana Margarida Silva, Stefano Dall'Acqua, Stefania Sut, Anna Vallverdu-Queralt, Cristina Delerue-Matos, Francisca Rodrigues
Summary: This study investigates the effects of in vitro gastrointestinal digestion and intestinal permeability on the bioaccessibility and bioactivity of polyphenols from chestnut shells extract. The results show that the polyphenol concentrations are higher after gastric and intestinal digestion. The study also reveals the potential hypoglycemic and neuroprotective properties of the extract, along with its ability to upregulate antioxidant enzymes and downregulate lipid peroxidation.
Article
Biochemistry & Molecular Biology
Filipa Teixeira, Ana Margarida Silva, Stefania Sut, Stefano Dall'Acqua, Cristina Delerue-Matos, Berta Estevinho, Paulo C. Costa, Francisca Rodrigues
Summary: The aim of this study was to produce polymeric particles of Actinidia arguta leaves extract by spray-drying to improve the condition of oral mucositis. The results showed that the extract microparticles had good antioxidant and antiradical activities, and no adverse effects on oral cells, highlighting their potential applications in the pharmaceutical and nutraceutical industries.
Article
Food Science & Technology
Elsa F. Vieira, Ana Q. Fontoura, Cristina Delerue-Matos
Summary: Chayote seed protein isolates were prepared using alkaline extraction and ultrasonic-assisted extraction. The ultrasonic-assisted extraction significantly improved the protein extraction yield and functional properties. Chayote seed protein isolates obtained by ultrasonic-assisted extraction showed high nutritional and commercial value.
