Article
Oncology
Maria Teresa Rodrigo-Calvo, Karmele Saez de Gordoa, Sandra Lopez-Prades, Ivan Archilla, Alba Diaz, Mario Berrios, Jordi Camps, Eva Musulen, Miriam Cuatrecasas
Summary: The aim of this study was to identify lymphatic vessels (LVs) in the mucosa of in-situ colorectal cancer (CRC) and detect tumor burden in regional lymph nodes (LNs). LVs were found in the mucosa of all tumors (39/39; 100%) using D240 immunostains. LNs were analyzed by both H&E and a RT-PCR-based molecular method. Low amounts of tumor burden were detected in 11/39 (28%) cases using the molecular assay. The quantification of tumor burden in LNs can help with clinical management.
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article
Oncology
Chongyu Zhao, Xiyuan Li, Li Luo, Cheng Chen, Chaobin He
Summary: This study aimed to explore the optimal positive lymph node cutoff value for predicting survival outcomes in patients with iCCA and establish a prognostic nomogram. The results showed that patients with 1-3 positive lymph nodes had significantly better overall survival compared to those with more than 4 positive lymph nodes. This study provides new evidence for more precise post-operative management of iCCA patients.
CANCER CELL INTERNATIONAL
(2023)
Review
Medicine, Research & Experimental
Qingwei Ren, Yanyan Chen, Xuejun Shao, Lanzhong Guo, Xinxin Xu
Summary: This study aims to assess the diagnostic efficacy of 18F-FDG PET/MRI for lymph node (LN) metastasis primary staging in patients with colorectal cancer (CRC). The analysis showed that 18F-FDG PET/MRI has remarkable diagnostic performance in identifying LN metastases in newly diagnosed CRC patients, and it has great application value for the primary staging of CRC lymph node metastases.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Summary: This study evaluated clinical strategies based on sonographic features of lymph nodes and found that detecting malignant lymph nodes through FNAC or elevated FNA-Tg had a high malignancy rate, while stratification based on sonographic features was necessary for nodes with indeterminate or benign results. A diagnostic algorithm combining FNAC, FNA-Tg, and ultrasound features was proposed for diagnosing metastatic lymph nodes of differentiated thyroid carcinomas.
Article
Oncology
Felipe A. C. Luz, Rogerio A. Araujo, Marcelo J. B. Silva
Summary: The sentinel lymph node biopsy is a safe and efficient approach compared to total axillary lymph node dissection for initial patients. A SEER-based study showed that having two positive lymph nodes is a poor prognostic factor similar to pN2 patients. Positive-to-analyzed LN proportion and negative LN margin are strong prognostic factors for survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Nadia Russolillo, Alessandro Borello, Serena Langella, Michele Casella, Roberto Lo Tesoriere, Alessandro Ferrero
Summary: The study showed that preoperative MRI in CRLMs patients undergoing LLR can predict liver metastases, while LUS can additionally detect new nodules, helping adjust surgical strategy and improve accuracy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Otorhinolaryngology
Ha Na Lee, Chang Myeon Song, Yong Bae Ji, Jae Kyung Myung, Young-Jun Lee, Kyung Tae
Summary: This study evaluated the incidence and risk factors of occult metastasis to superficial level VI in patients with papillary thyroid carcinoma. The results showed that lymph nodes were found in approximately 48% of the harvested specimens of superficial level VI. However, the occurrence rate of occult metastasis to superficial level VI was relatively low, suggesting that prophylactic dissection of superficial level VI may not be necessary for primary papillary thyroid carcinoma.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemical Research Methods
Lindsey A. Barner, Adam K. Glaser, Chenyi Mao, Etsuo A. Susaki, Joshua C. Vaughan, Suzanne M. Dintzis, Jonathan T. C. Liu
Summary: The 3D pathology method can improve staging accuracy of lymph node metastases for breast cancer patients, leading to better clinical management.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Oncology
Nan-Chin Lin, I-Hsien Su, Jui-Ting Hsu, Yu-Jun Chang, Kuo-Yang Tsai
Summary: The study compared the prognostic abilities of different lymph node staging systems for oral cavity squamous cell carcinoma (OSCC)-positive nodes, finding that lymph node density (LND), log odds of positive lymph nodes (LODDS), and number of metastatic lymph nodes (nmLN) systems predicted disease-free survival (DFS) better than the traditional AJCC N staging. Further analysis revealed that LND and LODDS were more accurate in predicting DFS compared to pathological N staging.
Article
Gastroenterology & Hepatology
Sung Hyun Kim, Dai Hoon Han, Gi Hong Choi, Jin Sub Choi, Kyung Sik Kim
Summary: For patients with intrahepatic cholangiocarcinoma (ICC), it is recommended to perform lymph node dissection (LND) including at least stations no. 12 (hepatoduodenal ligament) and 8 (common hepatic artery) for accurate staging. In lymph node-negative group, LND covering stations no. 8+12 appears to improve disease-free survival (DFS) and overall survival (OS) outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Cell Biology
Noelle Leary, Sarina Walser, Yuliang He, Nikola Cousin, Paulo Pereira, Alessandro Gallo, Victor Collado-Diaz, Cornelia Halin, Susana Garcia-Silva, Hector Peinado, Lothar C. Dieterich
Summary: EV-mediated communication between melanoma and lymph node endothelial cells is identified as a new pathway involved in tumor progression and immune inhibition. These extracellular vesicles are transported rapidly to lymph nodes through lymphatic vessels and interact with endothelial cells and macrophages.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Medicine, General & Internal
Hee Jun Choi, Jai Min Ryu, Jun Ho Lee, Yoonju Bang, Jongwook Oh, Byung-Joo Chae, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Se Kyung Lee, Jonghan Yu
Summary: This study evaluated the prognostic value of the number of lymph nodes removed in breast cancer patients who underwent axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC). The results showed that in certain subgroups, patients with less than 10 lymph nodes removed had worse prognosis and may require closer monitoring.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Chen-Lu Lian, Hai-Yan Zhang, Jun Wang, Jian Lei, Li Hua, Yong-Xiong Chen, San-Gang Wu
Summary: The study validated the applicability of the 8th AJCC pathological prognostic staging system for breast cancer patients with internal mammary lymph nodes metastasis, showing improved prognostic stratification and better prediction of prognosis for this specific subgroup of breast cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Yi Zeng, Fenglin Cai, Pengliang Wang, Xinyu Wang, Yong Liu, Li Zhang, Rupeng Zhang, Luchuan Chen, Han Liang, Zaisheng Ye, Jingyu Deng
Summary: This study aims to establish a prognostic model based on extragastric lymph node metastasis (ELNM) and lymph node ratio (LNR) in node-positive gastric cancer (GC). The results show that this model has good prognostic prediction in patients with node-positive GC.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Sanne-Marije Hazen, Tania Sluckin, Geerard Beets, Roel Hompes, Pieter Tanis, Miranda Kusters
Summary: There is significant variation among Dutch colorectal surgeons in the assessment and treatment of lateral lymph nodes in rectal cancer patients, highlighting the need for further research and international guidelines.
ACTA CHIRURGICA BELGICA
(2023)
Article
Surgery
Vivian P. Bastiaenen, Joske de Jonge, Bartholomeus J. G. A. Corten, Elise A. J. de Savornin Lohman, Anne C. Kraima, Hilko A. Swank, Jaap L. P. van Vliet, Gijs J. D. van Acker, Anna A. W. van Geloven, Klaas H. in't Hof, Lianne Koens, Philip R. de Reuver, Charles C. van Rossem, Gerrit D. Slooter, Pieter J. Tanis, Valeska Terpstra, Marcel G. W. Dijkgraaf, Willem A. Bemelman
Summary: The study investigates the oncological safety and potential cost savings of selective histopathological examination after appendectomy. The results suggest that this selective policy is oncologically safe and can reduce the workload of pathologists, save costs, and minimize re-resections without clear benefits.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nino Bogveradze, Monique Maas, Najim el Khababi, Niels W. Schurink, Max J. Lahaye, Frans C. H. Bakers, Pieter J. Tanis, Miranda Kusters, Geerard L. Beets, Regina G. H. Beets-Tan, Doenja M. J. Lambregts
Summary: Combining CT with MRI, especially for junior readers, can provide more confidence in using STO to localize rectal and sigmoid cancers, thus improving diagnostic accuracy.
Review
Gastroenterology & Hepatology
A. A. J. Gruter, A. S. van Lieshout, S. E. van Oostendorp, J. C. F. Ket, M. Tenhagen, F. C. den Boer, R. Hompes, P. J. Tanis, J. B. Tuynman
Summary: The aim of this systematic review was to determine the distance and incidence of distal mesorectal spread. The results showed that distal mesorectal spread occurred in 11% of cases, with an average distance of 20.2mm. Overtreatment is present if a distal margin of 5cm is routinely utilized.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Gastroenterology & Hepatology
M. D. Slooter, E. M. L. van der Does de Willebois, J. J. Joosten, M. A. Reijntjes, C. J. Buskens, P. J. Tanis, W. A. Bemelman, R. Hompes
Summary: This study evaluated the impact of vascular ligation during ileal pouch-anal anastomosis on the time to fluorescence enhancement during intraoperative fluorescence angiography. The results showed that vascular ligation may prolong the time to fluorescence enhancement, possibly due to arterial rerouting and venous outflow obstruction.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Review
Gastroenterology & Hepatology
Floris P. J. den Hartog, Sarah van Egmond, Marijn M. Poelman, Anand G. Menon, Gert-Jan Kleinrensink, Johan F. Lange, Pieter J. Tanis, Eva B. Deerenberg
Summary: The aim of this study was to determine the pooled incidence of incisional hernia (IH) for each type of extraction site and compare the rates of IH after midline, nonmidline, and Pfannenstiel extraction.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Andrea Balla, Federica Saraceno, Marika Rullo, Salvador Morales-Conde, Eduardo M. Targarona Soler, Salomone Di Saverio, Mario Guerrieri, Pasquale Lepiane, Nicola Di Lorenzo, Michel Adamina, Isaias Alarcon, Alberto Arezzo, Jesus Bollo Rodriguez, Luigi Boni, Sebastiano Biondo, Francesco Maria Carrano, Manish Chand, John T. Jenkins, Justin Davies, Salvadora Delgado Rivilla, Paolo Delrio, Ugo Elmore, Eloy Espin-Basany, Alessandro Fichera, Blas Flor Lorente, Nader Francis, Marcos Gomez Ruiz, Dieter Hahnloser, Eugenio Licardie, Carmen Martinez, Monica Ortenzi, Yves Panis, Carlos Pastor Idoate, Alessandro M. Paganini, Miguel Pera, Roberto Perinotti, Daniel A. Popowich, Timothy Rockall, Riccardo Rosati, Alberto Sartori, Daniele Scoglio, Mostafa Shalaby, Vicente Simo Fernandez, Neil J. Smart, Antonino Spinelli, Patricia Sylla, Pieter J. Tanis, Javier Valdes-Hernandez, Steven D. Wexner, Pierpaolo Sileri
Summary: This qualitative study investigated the decision-making process of surgeons regarding protective ileostomy creation after rectal cancer surgery. The results showed that 76% of surgeons supported the creation of ileostomy. When making the decision, 88% of surgeons considered risk factors. Emotions influenced the decision-making process in 22% of cases, and personal experiences influenced it in 49% of cases. The most frequently considered risk factors were the distance between the anus and the tumor (96%), neoadjuvant chemoradiotherapy (88%), positive intraoperative leak test (65%), blood loss (37%), and immunosuppression therapy (35%).
COLORECTAL DISEASE
(2023)
Article
Oncology
Bobby Zamaray, J. V. Veld, T. A. Burghgraef, R. Brohet, H. L. van Westreenen, J. E. van Hooft, P. D. Siersema, P. J. Tanis, E. C. J. Consten
Summary: This retrospective multicentre cohort study aimed to identify risk factors for a permanent stoma (PS) in patients with left-sided obstructive colon cancer (LSOCC) and develop pre- and postoperative prediction models. The results showed that 37% of LSOCC patients had a PS, and 53% of those with a stoma directly after resection had a PS due to non-reversal. Both baseline characteristics and treatment strategies determine the risk of a PS in LSOCC patients. The developed predictive models will help physicians understand the role of individual variables in the risk of a PS and inform patients about the probability of a PS.
Correction
Surgery
Anouk. M. L. H. Emmen, B. Goergec, M. J. W. Zwart, F. Daams, J. Erdmann, S. Festen, D. J. Gouma, T. M. van Gulik, J. van Hilst, G. Kazemier, S. Lof, S. I. Sussenbach, P. J. Tanis, B. M. Zonderhuis, O. R. Busch, R. J. Swijnenburg, M. G. Besselink
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Anouk M. L. H. Emmen, B. Gorgec, M. J. W. Zwart, F. Daams, J. Erdmann, S. Festen, D. J. Gouma, T. M. van Gulik, J. van Hilst, G. Kazemier, S. Lof, S. Sussenbach, P. J. Tanis, B. M. Zonderhuis, O. R. Busch, R. J. Swijnenburg, M. G. Besselink
Summary: This study assessed the safety and feasibility of robot-assisted laparoscopic hepato-pancreato-biliary surgery. The results showed that the introduction of robotic surgery increased the utilization of laparoscopic HPB surgery and improved some selected outcomes, but had no significant impact on mortality and major complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Jan M. Van Rees, Lissa Wullaert, Alexander A. J. Grueter, Yassmina Derraze, Pieter J. Tanis, Henk M. W. Verheul, John W. M. Martens, Saskia M. Wilting, Geraldine Vink, Jeroen L. A. Van Vugt, Nick Beije, Cornelis Verhoef
Summary: This systematic review and meta-analyses demonstrate a strong association between ctDNA and recurrent disease in non-metastatic rectal cancer. ctDNA analysis can stratify patients into high and low risk groups for recurrence, especially when detected after neoadjuvant treatment and surgery. Future research should focus on the feasibility of ctDNA-guided treatment and follow-up strategies in rectal cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
C. Bakkers, K. P. Rovers, A. Rijken, G. A. A. M. Simkens, C. S. Bonhof, S. W. Nienhuijs, J. W. A. Burger, G. J. M. Creemers, A. R. M. Brandt-Kerkhof, J. B. Tuynman, A. G. J. Aalbers, M. J. Wiezer, P. R. de Reuver, W. M. U. van Grevenstein, P. H. J. Hemmer, C. J. A. Punt, P. J. Tanis, F. Mols, I. H. J. T. de Hingh
Summary: In a randomized phase II trial, the study compared the patient-reported outcomes (PROs) of patients with colorectal peritoneal metastases (CPMs) who received perioperative systemic therapy or cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone. The results showed that there were comparable PROs between the two groups at 3 and 6 months postoperatively, indicating acceptable tolerance of perioperative systemic therapy in this setting.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Jasper Paul Sijberden, Antonino Spinelli, Alessandro Ferrero, Manish Chand, Steven Wexner, Marc G. Besselink, Ibrahim Dagher, Giuseppe Zimmitti, Burak Gorgec, Antonio de Lacy, Mayank Roy, Pieter Tanis, Carlo Tonti, Mohammed Abu Hilal
Summary: This study aimed to assess the attitudes of surgeons involved in the treatment of synchronous colorectal liver metastases (sCRLM). The study found that there were differences in clinical practices and viewpoints on the management of sCRLM among surgeons from different specialties and continents. However, there was consensus on a growing role for minimally invasive surgery (MIS) and a need for evidence-based input.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Alexander A. J. Grueter, Annabel S. S. Van Lieshout, Stefan E. E. van Oostendorp, Sofie P. G. Henckens, Johannes C. F. Ket, Suzanne S. S. Gisbertz, Boudewijn R. R. Toorenvliet, Pieter J. J. Tanis, Hendrik J. J. Bonjer, Jurriaan B. B. Tuynman
Summary: This systematic review provides a comprehensive overview of video-based objective surgical quality assessment (SQA) tools in laparoscopic procedures. The findings suggest that validated SQA tools enable objective assessment of surgical performance and are associated with clinical outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
K. Talboom, N. G. Greijdanus, N. Brinkman, R. D. Blok, S. X. Roodbeen, C. Y. Ponsioen, P. J. Tanis, W. A. Bemelman, C. Cunningham, F. B. de Lacy, Roel Hompes
Summary: This study aimed to compare different treatment strategies for anastomotic leakage (AL) after low anterior resection (LAR) and found that endoscopic vacuum-assisted surgical closure (EVASC) resulted in improved rates of healed and functional anastomosis compared to conventional treatment. Early initiation of EVASC within the first week after surgery achieved a 100% functional anastomosis rate.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
